FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120218359> ?p ?o ?g. }

• W2120218359 endingPage "264" @default.
• W2120218359 startingPage "251" @default.
• W2120218359 abstract "Abstract Curcumin is known to be a potent wound healer. Despite this, studies on curcumin using certain model systems have shown it to be anti‐angiogenic. Results of the present investigations suggest that curcumin causes opposing effects on angiogenesis in serum stimulated and unstimulated conditions. The evidence in support of this are: (a) in serum free conditions, curcumin promoted sprouting in rat aortic ring, increased vascular density in CAM and induced morphological changes indicative of angiogenic phenotype in HUVECs and rat aortic endothelial cells in culture, (b) increased the expression of biochemical markers of angiogenesis such as CD 31, E‐selectin, VEGF and VEGFR‐2 in HUVECs on treatment with curcumin, and (c) supplementation of curcumin along with serum caused decrease in CD 31 and E‐selectin levels, downregulation of VEGF, angiopoietin‐1 and VEGFR‐2 and delayed formation of capillary network‐like structure. Proangiogenic effect of the individual components of the natural curcumin differed and the presence of the three components in the natural mixture has a synergistic effect. Effect of curcuminoids in the absence of serum appears to depend on VEGF as (a) anti‐VEGF antibody blocked the effect of curcuminoids (b) curcuminoids caused decrease in PAR modification of VEGF increasing its biological activity. Treatment with curcuminoids in serum‐free conditions resulted in activation of PI3K‐Akt pathway; but in serum‐supplemented condition, curcuminoids caused inhibition of the MAPK pathways thereby inhibiting the expression of angiogenic phenotype. These results suggest that PI3K‐Akt and MAPK pathways involved in the expression of angiogenic phenotype respond differently to the extracellular microenvironment. J. Cell. Physiol. 215: 251–264, 2008. © 2007 Wiley‐Liss, Inc." @default.
• W2120218359 created "2016-06-24" @default.
• W2120218359 creator A5003262332 @default.
• W2120218359 creator A5020517487 @default.
• W2120218359 creator A5058260463 @default.
• W2120218359 creator A5070653789 @default.
• W2120218359 creator A5074037784 @default.
• W2120218359 creator A5089658565 @default.
• W2120218359 date "2007-10-24" @default.
• W2120218359 modified "2023-09-29" @default.
• W2120218359 title "Opposing effects of curcuminoids on serum stimulated and unstimulated angiogenic response" @default.
• W2120218359 cites W1679229092 @default.
• W2120218359 cites W175416543 @default.
• W2120218359 cites W1775749144 @default.
• W2120218359 cites W1966931906 @default.
• W2120218359 cites W1984474728 @default.
• W2120218359 cites W1988586260 @default.
• W2120218359 cites W1991178530 @default.
• W2120218359 cites W1992331688 @default.
• W2120218359 cites W1995179792 @default.
• W2120218359 cites W1995827857 @default.
• W2120218359 cites W1995878705 @default.
• W2120218359 cites W2005357676 @default.
• W2120218359 cites W2013128717 @default.
• W2120218359 cites W2014423637 @default.
• W2120218359 cites W2043632706 @default.
• W2120218359 cites W2043774753 @default.
• W2120218359 cites W2047841570 @default.
• W2120218359 cites W2048620231 @default.
• W2120218359 cites W2048635128 @default.
• W2120218359 cites W2048639599 @default.
• W2120218359 cites W2060334940 @default.
• W2120218359 cites W2065237225 @default.
• W2120218359 cites W2066088911 @default.
• W2120218359 cites W2068868559 @default.
• W2120218359 cites W2074190587 @default.
• W2120218359 cites W2082582610 @default.
• W2120218359 cites W2084855813 @default.
• W2120218359 cites W2095539104 @default.
• W2120218359 cites W2101108802 @default.
• W2120218359 cites W2111205112 @default.
• W2120218359 cites W2112547972 @default.
• W2120218359 cites W2112871946 @default.
• W2120218359 cites W2117310637 @default.
• W2120218359 cites W2121166735 @default.
• W2120218359 cites W2123615259 @default.
• W2120218359 cites W2130584475 @default.
• W2120218359 cites W2136215812 @default.
• W2120218359 cites W2137159939 @default.
• W2120218359 cites W2145779577 @default.
• W2120218359 cites W2157603347 @default.
• W2120218359 cites W2163121468 @default.
• W2120218359 cites W2168438265 @default.
• W2120218359 cites W2169520365 @default.
• W2120218359 cites W2298906034 @default.
• W2120218359 cites W4231645290 @default.
• W2120218359 doi "https://doi.org/10.1002/jcp.21307" @default.
• W2120218359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17960570" @default.
• W2120218359 hasPublicationYear "2007" @default.
• W2120218359 type Work @default.
• W2120218359 sameAs 2120218359 @default.
• W2120218359 citedByCount "26" @default.
• W2120218359 countsByYear W21202183592012 @default.
• W2120218359 countsByYear W21202183592013 @default.
• W2120218359 countsByYear W21202183592014 @default.
• W2120218359 countsByYear W21202183592015 @default.
• W2120218359 countsByYear W21202183592016 @default.
• W2120218359 countsByYear W21202183592017 @default.
• W2120218359 countsByYear W21202183592018 @default.
• W2120218359 countsByYear W21202183592019 @default.
• W2120218359 countsByYear W21202183592021 @default.
• W2120218359 countsByYear W21202183592022 @default.
• W2120218359 crossrefType "journal-article" @default.
• W2120218359 hasAuthorship W2120218359A5003262332 @default.
• W2120218359 hasAuthorship W2120218359A5020517487 @default.
• W2120218359 hasAuthorship W2120218359A5058260463 @default.
• W2120218359 hasAuthorship W2120218359A5070653789 @default.
• W2120218359 hasAuthorship W2120218359A5074037784 @default.
• W2120218359 hasAuthorship W2120218359A5089658565 @default.
• W2120218359 hasConcept C104317684 @default.
• W2120218359 hasConcept C127561419 @default.
• W2120218359 hasConcept C185592680 @default.
• W2120218359 hasConcept C2778250585 @default.
• W2120218359 hasConcept C2778271429 @default.
• W2120218359 hasConcept C2780394083 @default.
• W2120218359 hasConcept C502942594 @default.
• W2120218359 hasConcept C55493867 @default.
• W2120218359 hasConcept C57074206 @default.
• W2120218359 hasConcept C62478195 @default.
• W2120218359 hasConcept C75217442 @default.
• W2120218359 hasConcept C86554907 @default.
• W2120218359 hasConcept C86803240 @default.
• W2120218359 hasConcept C98274493 @default.
• W2120218359 hasConceptScore W2120218359C104317684 @default.
• W2120218359 hasConceptScore W2120218359C127561419 @default.
• W2120218359 hasConceptScore W2120218359C185592680 @default.
• W2120218359 hasConceptScore W2120218359C2778250585 @default.
• W2120218359 hasConceptScore W2120218359C2778271429 @default.

• next