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• W2120219746 abstract "PCR-based subtractive hybridisation was used to identify genes up-regulated when pericytes undergo osteogenic differentiation and deposit a calcified matrix. cDNA pools were generated from confluent pericytes and from pericyte cultures containing calcified nodules. A pericyte cDNA library was screened with the product of the subtraction procedure (calcified minus confluent cDNA) and the majority of the positive clones were identified as matrix Gla protein (MGP). Northern analysis and immunohistochemistry demonstrated that MGP was only expressed by pericytes in calcified nodules. Antibodies to MGP inhibited the deposition of a calcified matrix by pericytes, suggesting that MGP regulates both cell differentiation and calcification." @default.
• W2120219746 created "2016-06-24" @default.
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• W2120219746 date "2000-12-29" @default.
• W2120219746 modified "2023-09-26" @default.
• W2120219746 title "Matrix Gla protein is differentially expressed during the deposition of a calcified matrix by vascular pericytes" @default.
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• W2120219746 doi "https://doi.org/10.1016/s0014-5793(00)02363-2" @default.
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