Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120233219> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2120233219 endingPage "206" @default.
- W2120233219 startingPage "204" @default.
- W2120233219 abstract "Objectives To examine the effect of smoking on three first trimester screening markers for Down's syndrome that constitute the Combined test, namely nuchal translucency (NT), pregnancy-associated plasma protein-A (PAPP-A) and free β human chorionic gonadotophin (free β-hCG) and to use the results to determine which of these markers need to be adjusted for smoking and by how much. Methods The difference in the median multiple of the median (MoM) values in smokers compared to non-smokers was determined for NT, PAPP-A and free β-hCG in 12,517 unaffected pregnancies that had routine first trimester Combined test screening. These results were then included in a meta-analysis of published studies and the effect of adjusting for smoking on screening performance of the Combined test was estimated. Results The results using the routine screening data were similar to the summary estimates from the meta-analysis of all studies. The results from the meta-analysis were; median MoM in smokers compared to non-smokers: 1.06 NT (95% confidence interval 1.03 to 1.10), 0.81 PAPP-A (0.80 to 0.83) and 0.94 free β-hCG (0.89 to 0.99). The effect of adjusting for smoking on the Combined test is small, with an estimated less than half percentage point increase in the detection rate (the proportion of affected pregnancies with a positive result) for a 3% false-positive rate (the proportion of unaffected pregnancies with a positive result) and less than 0.2 percentage point decrease in the false-positive rate for an 85% detection rate. Conclusion Adjusting first trimester screening markers for smoking has a minimal favourable effect on screening performance, but it is simple to implement and this paper provides the adjustment factors needed if a decision is made to make such an adjustment." @default.
- W2120233219 created "2016-06-24" @default.
- W2120233219 creator A5048397189 @default.
- W2120233219 creator A5056651699 @default.
- W2120233219 creator A5061470498 @default.
- W2120233219 date "2008-12-01" @default.
- W2120233219 modified "2023-10-14" @default.
- W2120233219 title "First trimester Down's syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free β human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency" @default.
- W2120233219 cites W1969932371 @default.
- W2120233219 cites W1973708510 @default.
- W2120233219 cites W2020284509 @default.
- W2120233219 cites W2028621007 @default.
- W2120233219 cites W2057850065 @default.
- W2120233219 cites W2107328434 @default.
- W2120233219 cites W2158115946 @default.
- W2120233219 cites W2158612397 @default.
- W2120233219 cites W2159188458 @default.
- W2120233219 cites W2412527470 @default.
- W2120233219 doi "https://doi.org/10.1258/jms.2008.008049" @default.
- W2120233219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19106261" @default.
- W2120233219 hasPublicationYear "2008" @default.
- W2120233219 type Work @default.
- W2120233219 sameAs 2120233219 @default.
- W2120233219 citedByCount "19" @default.
- W2120233219 countsByYear W21202332192013 @default.
- W2120233219 countsByYear W21202332192014 @default.
- W2120233219 countsByYear W21202332192015 @default.
- W2120233219 countsByYear W21202332192017 @default.
- W2120233219 countsByYear W21202332192020 @default.
- W2120233219 countsByYear W21202332192023 @default.
- W2120233219 crossrefType "journal-article" @default.
- W2120233219 hasAuthorship W2120233219A5048397189 @default.
- W2120233219 hasAuthorship W2120233219A5056651699 @default.
- W2120233219 hasAuthorship W2120233219A5061470498 @default.
- W2120233219 hasConcept C118552586 @default.
- W2120233219 hasConcept C126322002 @default.
- W2120233219 hasConcept C131872663 @default.
- W2120233219 hasConcept C2778014424 @default.
- W2120233219 hasConcept C2779234561 @default.
- W2120233219 hasConcept C2779954681 @default.
- W2120233219 hasConcept C29456083 @default.
- W2120233219 hasConcept C3017541802 @default.
- W2120233219 hasConcept C3019085024 @default.
- W2120233219 hasConcept C3019714739 @default.
- W2120233219 hasConcept C44249647 @default.
- W2120233219 hasConcept C46973012 @default.
- W2120233219 hasConcept C54355233 @default.
- W2120233219 hasConcept C71924100 @default.
- W2120233219 hasConcept C86803240 @default.
- W2120233219 hasConcept C95190672 @default.
- W2120233219 hasConceptScore W2120233219C118552586 @default.
- W2120233219 hasConceptScore W2120233219C126322002 @default.
- W2120233219 hasConceptScore W2120233219C131872663 @default.
- W2120233219 hasConceptScore W2120233219C2778014424 @default.
- W2120233219 hasConceptScore W2120233219C2779234561 @default.
- W2120233219 hasConceptScore W2120233219C2779954681 @default.
- W2120233219 hasConceptScore W2120233219C29456083 @default.
- W2120233219 hasConceptScore W2120233219C3017541802 @default.
- W2120233219 hasConceptScore W2120233219C3019085024 @default.
- W2120233219 hasConceptScore W2120233219C3019714739 @default.
- W2120233219 hasConceptScore W2120233219C44249647 @default.
- W2120233219 hasConceptScore W2120233219C46973012 @default.
- W2120233219 hasConceptScore W2120233219C54355233 @default.
- W2120233219 hasConceptScore W2120233219C71924100 @default.
- W2120233219 hasConceptScore W2120233219C86803240 @default.
- W2120233219 hasConceptScore W2120233219C95190672 @default.
- W2120233219 hasIssue "4" @default.
- W2120233219 hasLocation W21202332191 @default.
- W2120233219 hasLocation W21202332192 @default.
- W2120233219 hasOpenAccess W2120233219 @default.
- W2120233219 hasPrimaryLocation W21202332191 @default.
- W2120233219 hasRelatedWork W2017565203 @default.
- W2120233219 hasRelatedWork W2021655181 @default.
- W2120233219 hasRelatedWork W2035810975 @default.
- W2120233219 hasRelatedWork W2050065579 @default.
- W2120233219 hasRelatedWork W2055811114 @default.
- W2120233219 hasRelatedWork W2076863926 @default.
- W2120233219 hasRelatedWork W2095045775 @default.
- W2120233219 hasRelatedWork W2115364205 @default.
- W2120233219 hasRelatedWork W2123585969 @default.
- W2120233219 hasRelatedWork W4253439116 @default.
- W2120233219 hasVolume "15" @default.
- W2120233219 isParatext "false" @default.
- W2120233219 isRetracted "false" @default.
- W2120233219 magId "2120233219" @default.
- W2120233219 workType "article" @default.