FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120241921> ?p ?o ?g. }

• W2120241921 endingPage "156" @default.
• W2120241921 startingPage "143" @default.
• W2120241921 abstract "The vitamin D endocrine system is involved in a wide variety of biological processes including bone metabolism, modulation of the immune response, and regulation of cell proliferation and differentiation. Variations in this endocrine system have, thus, been linked to several common diseases, including osteoarthritis (OA), diabetes, cancer, cardiovascular disease, and tuberculosis. Evidence to support this pleiotropic character of vitamin D has included epidemiological studies on circulating vitamin D hormone levels, but also genetic epidemiological studies. Genetic studies provide excellent opportunities to link molecular insights with epidemiological data and have therefore gained much interest. DNA sequence variations, which occur frequently in the population, are referred to as “polymorphisms” and can have modest and subtle but true biological effects. Their abundance in the human genome as well as their high frequencies in the human population have made them targets to explain variation in risk of common diseases. Recent studies have indicated many polymorphisms to exist in the vitamin D receptor (VDR) gene, but the influence of VDR gene polymorphisms on VDR protein function and signaling is largely unknown. So far, three adjacent restriction fragment length polymorphisms for BsmI, ApaI, and TaqI, respectively, at the 3′ end of the VDR gene have been the most frequently studied. Because these polymorphisms are probably nonfunctional, linkage disequilibrium with one or more truly functional polymorphisms elsewhere in the VDR gene is assumed to explain the associations observed. Research is therefore focussed on documenting additional polymorphisms across the VDR gene to verify this hypothesis and on trying to understand the functional consequences of the variations. Substantial progress has been made that will deepen our understanding of variability in the vitamin D endocrine system and might find applications in risk assessment of disease and in predicting response-to-treatment." @default.
• W2120241921 created "2016-06-24" @default.
• W2120241921 creator A5031530236 @default.
• W2120241921 creator A5034668013 @default.
• W2120241921 creator A5074093058 @default.
• W2120241921 creator A5079798885 @default.
• W2120241921 creator A5088091678 @default.
• W2120241921 date "2004-09-01" @default.
• W2120241921 modified "2023-10-17" @default.
• W2120241921 title "Genetics and biology of vitamin D receptor polymorphisms" @default.
• W2120241921 cites W1978085763 @default.
• W2120241921 cites W1978816777 @default.
• W2120241921 cites W1981554514 @default.
• W2120241921 cites W1989554921 @default.
• W2120241921 cites W1994784503 @default.
• W2120241921 cites W1995873764 @default.
• W2120241921 cites W2005936777 @default.
• W2120241921 cites W2007158870 @default.
• W2120241921 cites W2009180025 @default.
• W2120241921 cites W2009706138 @default.
• W2120241921 cites W2012177336 @default.
• W2120241921 cites W2016148705 @default.
• W2120241921 cites W2021131499 @default.
• W2120241921 cites W2023446056 @default.
• W2120241921 cites W2026252144 @default.
• W2120241921 cites W2027175836 @default.
• W2120241921 cites W2035483021 @default.
• W2120241921 cites W2035851016 @default.
• W2120241921 cites W2038779176 @default.
• W2120241921 cites W2041403617 @default.
• W2120241921 cites W2042103448 @default.
• W2120241921 cites W2050730569 @default.
• W2120241921 cites W2053157117 @default.
• W2120241921 cites W2057028645 @default.
• W2120241921 cites W2058401000 @default.
• W2120241921 cites W2061448281 @default.
• W2120241921 cites W2067027353 @default.
• W2120241921 cites W2069881608 @default.
• W2120241921 cites W2070504970 @default.
• W2120241921 cites W2071006898 @default.
• W2120241921 cites W2073870011 @default.
• W2120241921 cites W2074976965 @default.
• W2120241921 cites W2078140516 @default.
• W2120241921 cites W2078948301 @default.
• W2120241921 cites W2079261802 @default.
• W2120241921 cites W2079799322 @default.
• W2120241921 cites W2080650328 @default.
• W2120241921 cites W2081928163 @default.
• W2120241921 cites W2082467443 @default.
• W2120241921 cites W2083530199 @default.
• W2120241921 cites W2088378090 @default.
• W2120241921 cites W2094828610 @default.
• W2120241921 cites W2098137011 @default.
• W2120241921 cites W2116565400 @default.
• W2120241921 cites W2117263637 @default.
• W2120241921 cites W2131909737 @default.
• W2120241921 cites W2152664025 @default.
• W2120241921 cites W2163773735 @default.
• W2120241921 cites W2165232518 @default.
• W2120241921 cites W2166517626 @default.
• W2120241921 cites W2170396386 @default.
• W2120241921 cites W4233050605 @default.
• W2120241921 cites W4233320302 @default.
• W2120241921 cites W4236202318 @default.
• W2120241921 cites W4239959802 @default.
• W2120241921 cites W4241496443 @default.
• W2120241921 cites W4250695535 @default.
• W2120241921 cites W4254533553 @default.
• W2120241921 cites W4256306848 @default.
• W2120241921 doi "https://doi.org/10.1016/j.gene.2004.05.014" @default.
• W2120241921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15315818" @default.
• W2120241921 hasPublicationYear "2004" @default.
• W2120241921 type Work @default.
• W2120241921 sameAs 2120241921 @default.
• W2120241921 citedByCount "1251" @default.
• W2120241921 countsByYear W21202419212012 @default.
• W2120241921 countsByYear W21202419212013 @default.
• W2120241921 countsByYear W21202419212014 @default.
• W2120241921 countsByYear W21202419212015 @default.
• W2120241921 countsByYear W21202419212016 @default.
• W2120241921 countsByYear W21202419212017 @default.
• W2120241921 countsByYear W21202419212018 @default.
• W2120241921 countsByYear W21202419212019 @default.
• W2120241921 countsByYear W21202419212020 @default.
• W2120241921 countsByYear W21202419212021 @default.
• W2120241921 countsByYear W21202419212022 @default.
• W2120241921 countsByYear W21202419212023 @default.
• W2120241921 crossrefType "journal-article" @default.
• W2120241921 hasAuthorship W2120241921A5031530236 @default.
• W2120241921 hasAuthorship W2120241921A5034668013 @default.
• W2120241921 hasAuthorship W2120241921A5074093058 @default.
• W2120241921 hasAuthorship W2120241921A5079798885 @default.
• W2120241921 hasAuthorship W2120241921A5088091678 @default.
• W2120241921 hasBestOaLocation W21202419212 @default.
• W2120241921 hasConcept C104317684 @default.
• W2120241921 hasConcept C124490489 @default.
• W2120241921 hasConcept C134018914 @default.
• W2120241921 hasConcept C135763542 @default.

• next