FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120246124> ?p ?o ?g. }

• W2120246124 endingPage "1034" @default.
• W2120246124 startingPage "1021" @default.
• W2120246124 abstract "Abstract Prostate cancer subtypes are poorly defined and functional validation of drivers of ETS rearrangement–negative prostate cancer has not been conducted. Here, we identified an ETS− subtype of aggressive prostate cancer (ERG−MAP3K7delCHD1del) and used a novel developmental model and a cell line xenograft model to show that cosuppression of MAP3K7 and CHD1 expression promotes aggressive disease. Analyses of publicly available prostate cancer datasets revealed that MAP3K7 and CHD1 were significantly codeleted in 10% to 20% of localized tumors and combined loss correlated with poor disease-free survival. To evaluate the functional impact of dual MAP3K7–CHD1 loss, we suppressed Map3k7 and/or Chd1 expression in mouse prostate epithelial progenitor/stem cells (PrP/SC) and performed tissue recombination experiments in vivo. Dual shMap3k7–shChd1 PrP/SC recombinants displayed massive glandular atypia with regions of prostatic intraepithelial neoplasia and carcinoma apparent. Combined Map3k7–Chd1 suppression greatly disrupted normal prostatic lineage differentiation; dual recombinants displayed significant androgen receptor loss, increased neuroendocrine differentiation, and increased neural differentiation. Clinical samples with dual MAP3K7–CHD1 loss also displayed neuroendocrine and neural characteristics. In addition, dual Map3k7–Chd1 suppression promoted E-cadherin loss and mucin production in recombinants. MAP3K7 and CHD1 protein loss also correlated with Gleason grade and E-cadherin loss in clinical samples. To further validate the phenotype observed in the PrP/SC model, we suppressed MAP3K7 and/or CHD1 expression in LNCaP prostate cancer cells. Dual shMAP3K7–shCHD1 LNCaP xenografts displayed increased tumor growth and decreased survival compared with shControl, shMAP3K7, and shCHD1 xenografts. Collectively, these data identify coordinate loss of MAP3K7 and CHD1 as a unique driver of aggressive prostate cancer development. Cancer Res; 75(6); 1021–34. ©2015 AACR." @default.
• W2120246124 created "2016-06-24" @default.
• W2120246124 creator A5005340500 @default.
• W2120246124 creator A5005855266 @default.
• W2120246124 creator A5013566244 @default.
• W2120246124 creator A5031205173 @default.
• W2120246124 creator A5035288099 @default.
• W2120246124 creator A5035378993 @default.
• W2120246124 creator A5040310884 @default.
• W2120246124 creator A5058481800 @default.
• W2120246124 creator A5063237176 @default.
• W2120246124 creator A5065846931 @default.
• W2120246124 creator A5067116284 @default.
• W2120246124 creator A5067653842 @default.
• W2120246124 creator A5071763026 @default.
• W2120246124 creator A5072384926 @default.
• W2120246124 creator A5076664506 @default.
• W2120246124 creator A5077001119 @default.
• W2120246124 creator A5077413102 @default.
• W2120246124 creator A5079388843 @default.
• W2120246124 creator A5086975790 @default.
• W2120246124 date "2015-03-12" @default.
• W2120246124 modified "2023-10-12" @default.
• W2120246124 title "Coordinate Loss of <i>MAP3K7</i> and <i>CHD1</i> Promotes Aggressive Prostate Cancer" @default.
• W2120246124 cites W1513463948 @default.
• W2120246124 cites W1538955795 @default.
• W2120246124 cites W1541516070 @default.
• W2120246124 cites W1575383081 @default.
• W2120246124 cites W1612799755 @default.
• W2120246124 cites W1902879109 @default.
• W2120246124 cites W1963749564 @default.
• W2120246124 cites W1969947723 @default.
• W2120246124 cites W1980415233 @default.
• W2120246124 cites W1985683228 @default.
• W2120246124 cites W1986799557 @default.
• W2120246124 cites W1992802708 @default.
• W2120246124 cites W1993368552 @default.
• W2120246124 cites W1994847090 @default.
• W2120246124 cites W1997587288 @default.
• W2120246124 cites W1999339142 @default.
• W2120246124 cites W2005792688 @default.
• W2120246124 cites W2011211995 @default.
• W2120246124 cites W2011957420 @default.
• W2120246124 cites W2012671266 @default.
• W2120246124 cites W2017329417 @default.
• W2120246124 cites W2026302623 @default.
• W2120246124 cites W2027631710 @default.
• W2120246124 cites W2038253558 @default.
• W2120246124 cites W2039544142 @default.
• W2120246124 cites W2049205984 @default.
• W2120246124 cites W2051025382 @default.
• W2120246124 cites W2053304050 @default.
• W2120246124 cites W2054598829 @default.
• W2120246124 cites W2077413589 @default.
• W2120246124 cites W2077619994 @default.
• W2120246124 cites W2079599988 @default.
• W2120246124 cites W2085019446 @default.
• W2120246124 cites W2087207490 @default.
• W2120246124 cites W2094817063 @default.
• W2120246124 cites W2095887087 @default.
• W2120246124 cites W2107633226 @default.
• W2120246124 cites W2109373293 @default.
• W2120246124 cites W2114843025 @default.
• W2120246124 cites W2124907227 @default.
• W2120246124 cites W2148214708 @default.
• W2120246124 cites W2149441684 @default.
• W2120246124 cites W2155058151 @default.
• W2120246124 cites W2159715390 @default.
• W2120246124 cites W2162417460 @default.
• W2120246124 cites W2169961966 @default.
• W2120246124 cites W2170233852 @default.
• W2120246124 cites W2170725518 @default.
• W2120246124 cites W2172123503 @default.
• W2120246124 cites W2219978888 @default.
• W2120246124 doi "https://doi.org/10.1158/0008-5472.can-14-1596" @default.
• W2120246124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4531265" @default.
• W2120246124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25770290" @default.
• W2120246124 hasPublicationYear "2015" @default.
• W2120246124 type Work @default.
• W2120246124 sameAs 2120246124 @default.
• W2120246124 citedByCount "70" @default.
• W2120246124 countsByYear W21202461242015 @default.
• W2120246124 countsByYear W21202461242016 @default.
• W2120246124 countsByYear W21202461242017 @default.
• W2120246124 countsByYear W21202461242018 @default.
• W2120246124 countsByYear W21202461242019 @default.
• W2120246124 countsByYear W21202461242020 @default.
• W2120246124 countsByYear W21202461242021 @default.
• W2120246124 countsByYear W21202461242022 @default.
• W2120246124 countsByYear W21202461242023 @default.
• W2120246124 crossrefType "journal-article" @default.
• W2120246124 hasAuthorship W2120246124A5005340500 @default.
• W2120246124 hasAuthorship W2120246124A5005855266 @default.
• W2120246124 hasAuthorship W2120246124A5013566244 @default.
• W2120246124 hasAuthorship W2120246124A5031205173 @default.
• W2120246124 hasAuthorship W2120246124A5035288099 @default.
• W2120246124 hasAuthorship W2120246124A5035378993 @default.
• W2120246124 hasAuthorship W2120246124A5040310884 @default.

• next