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• W2120257588 startingPage "5913" @default.
• W2120257588 abstract "Abstract We have tested the capability of a plasmid DNA (pDNA) expressing the EBV nuclear Ag-4 (EBNA-4) to evoke a T cell response-associated protective immune response against a tumor expressing this gene. We have found that ACA mice immunized with EBNA-4-expressing plasmid were partially protected against syngeneic mammary carcinoma line (S6C) expressing EBNA-4 (S6C-E4). This protection was enhanced by coimmunizing mice with EBNA-4- and GM-CSF-expressing plasmids, and a full protection was achieved by coimmunizing mice with EBNA-4- and IFN-γ-expressing plasmids. Furthermore, mice that have rejected the EBNA-4-positive tumor were also resistant against a subsequent challenge with the original nontransfected tumor line. We then checked for the ability of pDNA immunization to provide a protective long-term memory response. We indeed found that even after 3 mo from the last immunization, full protection was obtained by this method, as compared with full tumor outgrowth in the control-immunized group. These findings support the concept that a nonviral, pDNA-based vaccination strategy is useful to fully protect from the outgrowth of tumors expressing this EBV gene." @default.
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• W2120257588 date "1999-12-01" @default.
• W2120257588 modified "2023-10-06" @default.
• W2120257588 title "A Long-Term Memory Obtained by Genetic Immunization Results in Full Protection from a Mammary Adenocarcinoma Expressing an EBV Gene" @default.
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• W2120257588 doi "https://doi.org/10.4049/jimmunol.163.11.5913" @default.
• W2120257588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10570277" @default.
• W2120257588 hasPublicationYear "1999" @default.
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