FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120276586> ?p ?o ?g. }

• W2120276586 endingPage "2279" @default.
• W2120276586 startingPage "2271" @default.
• W2120276586 abstract "Abstract IRF4 is a transcription factor from the IRF factor family that plays pivotal roles in the differentiation and function of T and B lymphocytes. Although IRF4 is also expressed in dendritic cells (DCs) and macrophages, its roles in these cells in vivo are not clearly understood. In this study, conditional knockout mice that lack IRF4 in DCs or macrophages were generated and infected with Leishmania major. Mice lacking DC expression of IRF4 showed reduced footpad swelling compared with C57BL/6 mice, whereas those lacking IRF4 in macrophages did not. Mice with IRF4-deficient DCs also showed reduced parasite burden, and their CD4+ T cells produced higher levels of IFN-γ in response to L. major Ag. In the draining lymph nodes, the proportion of activated CD4+ T cells in these mice was similar to that in the control, but the proportion of IFN-γ–producing cells was increased, suggesting a Th1 bias in the immune response. Moreover, the numbers of migrating Langerhans cells and other migratory DCs in the draining lymph nodes were reduced both before and postinfection in mice with IRF4 defects in DCs, but higher levels of IL-12 were observed in IRF4-deficient DCs. These results imply that IRF4 expression in DCs inhibits their ability to produce IL-12 while promoting their migratory behavior, thus regulating CD4+ T cell responses against local infection with L. major." @default.
• W2120276586 created "2016-06-24" @default.
• W2120276586 creator A5018160333 @default.
• W2120276586 creator A5042185175 @default.
• W2120276586 creator A5049716043 @default.
• W2120276586 creator A5051431204 @default.
• W2120276586 creator A5054251357 @default.
• W2120276586 creator A5059704901 @default.
• W2120276586 creator A5091191492 @default.
• W2120276586 date "2014-03-01" @default.
• W2120276586 modified "2023-09-24" @default.
• W2120276586 title "IRF4 in Dendritic Cells Inhibits IL-12 Production and Controls Th1 Immune Responses against <i>Leishmania major</i>" @default.
• W2120276586 cites W1595293335 @default.
• W2120276586 cites W1900229962 @default.
• W2120276586 cites W1920927643 @default.
• W2120276586 cites W1951699079 @default.
• W2120276586 cites W1959677146 @default.
• W2120276586 cites W1961152800 @default.
• W2120276586 cites W1962910304 @default.
• W2120276586 cites W1973988310 @default.
• W2120276586 cites W1979514172 @default.
• W2120276586 cites W1981858801 @default.
• W2120276586 cites W1987481383 @default.
• W2120276586 cites W1996677125 @default.
• W2120276586 cites W2002204067 @default.
• W2120276586 cites W2010090099 @default.
• W2120276586 cites W2013433197 @default.
• W2120276586 cites W2022687427 @default.
• W2120276586 cites W2030206823 @default.
• W2120276586 cites W2041765961 @default.
• W2120276586 cites W2051908294 @default.
• W2120276586 cites W2056502408 @default.
• W2120276586 cites W2063277895 @default.
• W2120276586 cites W2063311617 @default.
• W2120276586 cites W2066992595 @default.
• W2120276586 cites W2071959000 @default.
• W2120276586 cites W2071969437 @default.
• W2120276586 cites W2072852987 @default.
• W2120276586 cites W2080935386 @default.
• W2120276586 cites W2081924135 @default.
• W2120276586 cites W2098765637 @default.
• W2120276586 cites W2111023345 @default.
• W2120276586 cites W2114675972 @default.
• W2120276586 cites W2120518161 @default.
• W2120276586 cites W2123602250 @default.
• W2120276586 cites W2127278205 @default.
• W2120276586 cites W2128983033 @default.
• W2120276586 cites W2131746171 @default.
• W2120276586 cites W2131933701 @default.
• W2120276586 cites W2134730420 @default.
• W2120276586 cites W2140988563 @default.
• W2120276586 cites W2141925741 @default.
• W2120276586 cites W2152014155 @default.
• W2120276586 cites W2156177776 @default.
• W2120276586 cites W2157274678 @default.
• W2120276586 cites W2159401431 @default.
• W2120276586 cites W2166557174 @default.
• W2120276586 cites W2167797671 @default.
• W2120276586 cites W2170951607 @default.
• W2120276586 doi "https://doi.org/10.4049/jimmunol.1301914" @default.
• W2120276586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24489086" @default.
• W2120276586 hasPublicationYear "2014" @default.
• W2120276586 type Work @default.
• W2120276586 sameAs 2120276586 @default.
• W2120276586 citedByCount "42" @default.
• W2120276586 countsByYear W21202765862014 @default.
• W2120276586 countsByYear W21202765862015 @default.
• W2120276586 countsByYear W21202765862016 @default.
• W2120276586 countsByYear W21202765862017 @default.
• W2120276586 countsByYear W21202765862018 @default.
• W2120276586 countsByYear W21202765862019 @default.
• W2120276586 countsByYear W21202765862020 @default.
• W2120276586 countsByYear W21202765862021 @default.
• W2120276586 countsByYear W21202765862022 @default.
• W2120276586 countsByYear W21202765862023 @default.
• W2120276586 crossrefType "journal-article" @default.
• W2120276586 hasAuthorship W2120276586A5018160333 @default.
• W2120276586 hasAuthorship W2120276586A5042185175 @default.
• W2120276586 hasAuthorship W2120276586A5049716043 @default.
• W2120276586 hasAuthorship W2120276586A5051431204 @default.
• W2120276586 hasAuthorship W2120276586A5054251357 @default.
• W2120276586 hasAuthorship W2120276586A5059704901 @default.
• W2120276586 hasAuthorship W2120276586A5091191492 @default.
• W2120276586 hasBestOaLocation W21202765861 @default.
• W2120276586 hasConcept C104317684 @default.
• W2120276586 hasConcept C12652872 @default.
• W2120276586 hasConcept C136764020 @default.
• W2120276586 hasConcept C203014093 @default.
• W2120276586 hasConcept C2778170410 @default.
• W2120276586 hasConcept C2780599195 @default.
• W2120276586 hasConcept C2781092759 @default.
• W2120276586 hasConcept C41008148 @default.
• W2120276586 hasConcept C54355233 @default.
• W2120276586 hasConcept C71928629 @default.
• W2120276586 hasConcept C86339819 @default.
• W2120276586 hasConcept C86803240 @default.
• W2120276586 hasConcept C8891405 @default.
• W2120276586 hasConcept C95444343 @default.

• next