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- W2120277543 abstract "The process of B cell production and differentiation is achieved in a highly regulated manner within the bone marrow of adult mammals (Osmond 1980). Many studies indicate that hematopoiesis is organized in a system where a multipotent stem cell (Sp) gives rise to progeny in all the hematopoietic lineages (Wu et al. 1968; Abramson et al. 1977). Although Sp have finite proliferative potential which can be exhausted by serial transplantation, single stem cells when injected into lethally irradiated recipients can fully reconstitute both myeloid and lymphoid function. Recently retroviral vectors have been used to introduce selectable clonal markers into hematopoietic stem cells to follow their expansion and differentiation in transplantation experiments (Joyner et al. 1983; Williams et al. 1984; Dick et al. 1985; Keller et al. 1985)." @default.
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- W2120277543 date "1989-01-01" @default.
- W2120277543 modified "2023-09-26" @default.
- W2120277543 title "The Scid Mouse as a Model to Identify and Quantify Myeloid and Lymphoid Stem Cells" @default.
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- W2120277543 doi "https://doi.org/10.1007/978-3-642-74974-2_21" @default.
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