FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120284109> ?p ?o ?g. }

• W2120284109 endingPage "421" @default.
• W2120284109 startingPage "417" @default.
• W2120284109 abstract "A phase II study with cyproterone acetate (CPA) was done as the primary treatment in female breast cancer patients. Twenty-three patients, mean age 64 years, range 52–75 years, were entered and treated with CPA 400 mg daily. Twenty patients were evaluable and responses were sparse. There was one partial and one complete remission, 17 patients were stable and one patient progressed within 3 months. Side-effects were frequent: five patients complained of nausea, three had severe weight loss, one suffered from depression and seven showed disturbed liver function tests. Six patients had to stop treatment for side-effects, while two other patients were taken off treatment because they developed an acute necrotizing hepatitis. The hepatitis recovered after drug withdrawal in both patients. The serum levels of CPA, cortisol, androstenedione, DHAS, LH, FSH and prolactin were measured during CPA treatment. The levels of cortisol and androstenedione did not change, while LH, FSH and DHAS were suppressed. The DHAS showed an inverse relation to serum CPA concentrations. The prolactin levels rose uniformly. The therapeutic effect of CPA in postmenopausal patients with advanced breast cancer is disappointing, and inferior to that of other progestins. Side-effects are frequent, possibly as a result of the high dosage used in this study. The hormonal changes are different from those of other progestins, which may explain the different efficacies." @default.
• W2120284109 created "2016-06-24" @default.
• W2120284109 creator A5006235124 @default.
• W2120284109 creator A5061495577 @default.
• W2120284109 creator A5062554631 @default.
• W2120284109 creator A5068253914 @default.
• W2120284109 creator A5078581728 @default.
• W2120284109 creator A5039422719 @default.
• W2120284109 date "1988-03-01" @default.
• W2120284109 modified "2023-09-30" @default.
• W2120284109 title "Clinical and endocrine effects of cyproterone acetate in postmenopausal patients with advanced breast cancer" @default.
• W2120284109 cites W1977676551 @default.
• W2120284109 cites W1978054190 @default.
• W2120284109 cites W1997614450 @default.
• W2120284109 cites W2014341557 @default.
• W2120284109 cites W2018774812 @default.
• W2120284109 cites W2037754133 @default.
• W2120284109 cites W2079292274 @default.
• W2120284109 cites W2085348201 @default.
• W2120284109 cites W2093260376 @default.
• W2120284109 cites W2124752916 @default.
• W2120284109 cites W2141237313 @default.
• W2120284109 cites W2335461982 @default.
• W2120284109 cites W2395442671 @default.
• W2120284109 cites W2468305077 @default.
• W2120284109 cites W4243116045 @default.
• W2120284109 doi "https://doi.org/10.1016/s0277-5379(98)90011-6" @default.
• W2120284109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2968261" @default.
• W2120284109 hasPublicationYear "1988" @default.
• W2120284109 type Work @default.
• W2120284109 sameAs 2120284109 @default.
• W2120284109 citedByCount "18" @default.
• W2120284109 countsByYear W21202841092013 @default.
• W2120284109 countsByYear W21202841092015 @default.
• W2120284109 countsByYear W21202841092016 @default.
• W2120284109 countsByYear W21202841092017 @default.
• W2120284109 countsByYear W21202841092018 @default.
• W2120284109 countsByYear W21202841092019 @default.
• W2120284109 crossrefType "journal-article" @default.
• W2120284109 hasAuthorship W2120284109A5006235124 @default.
• W2120284109 hasAuthorship W2120284109A5039422719 @default.
• W2120284109 hasAuthorship W2120284109A5061495577 @default.
• W2120284109 hasAuthorship W2120284109A5062554631 @default.
• W2120284109 hasAuthorship W2120284109A5068253914 @default.
• W2120284109 hasAuthorship W2120284109A5078581728 @default.
• W2120284109 hasConcept C121608353 @default.
• W2120284109 hasConcept C126322002 @default.
• W2120284109 hasConcept C134018914 @default.
• W2120284109 hasConcept C199360897 @default.
• W2120284109 hasConcept C2776306840 @default.
• W2120284109 hasConcept C2776683971 @default.
• W2120284109 hasConcept C2777155358 @default.
• W2120284109 hasConcept C2777176818 @default.
• W2120284109 hasConcept C2777911890 @default.
• W2120284109 hasConcept C2779064019 @default.
• W2120284109 hasConcept C2780580376 @default.
• W2120284109 hasConcept C2992208098 @default.
• W2120284109 hasConcept C3454156 @default.
• W2120284109 hasConcept C41008148 @default.
• W2120284109 hasConcept C46699223 @default.
• W2120284109 hasConcept C530470458 @default.
• W2120284109 hasConcept C71315377 @default.
• W2120284109 hasConcept C71924100 @default.
• W2120284109 hasConcept C90924648 @default.
• W2120284109 hasConceptScore W2120284109C121608353 @default.
• W2120284109 hasConceptScore W2120284109C126322002 @default.
• W2120284109 hasConceptScore W2120284109C134018914 @default.
• W2120284109 hasConceptScore W2120284109C199360897 @default.
• W2120284109 hasConceptScore W2120284109C2776306840 @default.
• W2120284109 hasConceptScore W2120284109C2776683971 @default.
• W2120284109 hasConceptScore W2120284109C2777155358 @default.
• W2120284109 hasConceptScore W2120284109C2777176818 @default.
• W2120284109 hasConceptScore W2120284109C2777911890 @default.
• W2120284109 hasConceptScore W2120284109C2779064019 @default.
• W2120284109 hasConceptScore W2120284109C2780580376 @default.
• W2120284109 hasConceptScore W2120284109C2992208098 @default.
• W2120284109 hasConceptScore W2120284109C3454156 @default.
• W2120284109 hasConceptScore W2120284109C41008148 @default.
• W2120284109 hasConceptScore W2120284109C46699223 @default.
• W2120284109 hasConceptScore W2120284109C530470458 @default.
• W2120284109 hasConceptScore W2120284109C71315377 @default.
• W2120284109 hasConceptScore W2120284109C71924100 @default.
• W2120284109 hasConceptScore W2120284109C90924648 @default.
• W2120284109 hasIssue "3" @default.
• W2120284109 hasLocation W21202841091 @default.
• W2120284109 hasLocation W21202841092 @default.
• W2120284109 hasOpenAccess W2120284109 @default.
• W2120284109 hasPrimaryLocation W21202841091 @default.
• W2120284109 hasRelatedWork W1972051303 @default.
• W2120284109 hasRelatedWork W1989148468 @default.
• W2120284109 hasRelatedWork W2005402639 @default.
• W2120284109 hasRelatedWork W2025216813 @default.
• W2120284109 hasRelatedWork W2037023116 @default.
• W2120284109 hasRelatedWork W2062690991 @default.
• W2120284109 hasRelatedWork W2068406290 @default.
• W2120284109 hasRelatedWork W2086288557 @default.
• W2120284109 hasRelatedWork W2100202028 @default.
• W2120284109 hasRelatedWork W2142416343 @default.

• next