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- W2120297851 abstract "This study examined the potential of daily brief meditation practice to improve depressive symptoms, distress, coping, quality of life, cognition, and inflammatory markers in stressed family dementia caregivers in a randomized study of yogic Kirtan kriya compared to relaxation practice. Thirty nine older family dementia caregivers (mean age 60.3 y.o. (SD = 10.2)) were randomized to practice Kirtan Kirya versus listening to the relaxation tapes for 20 minutes per day for 8 weeks. Severity of depressive symptoms, resilience, burden, distress, quality of life, suffering, and the severity of care-recipient's cognitive and behavioral disturbances were assessed at baseline and over the course of the study. The mean Hamilton Depression Rating Scale (HDRS) score at baseline was 11.6 (SD = 4.1). Cellular expression of the Nuclear Factor kappa Beta (NFkB), a protein complex that has been linked to chronic stress and inflammatory response, was examined in the lymphocytes and monocytes using intranuclear staining and flow cytometry. The severity of depressive symptoms improved in both groups. However, improvement in the quality of life, cognitive tests (Mini-Mental Status Exam and several executive function and memory tests) (p<0.05) were greater among caregivers practicing meditation compared to the relaxation group and were accompanied by improvements in sleep, anxiety, and perceived burden. The preliminary data also demonstrated significant decreases in NFkB expression in the meditation group compared to the relaxation group. This pilot randomized study found that brief daily meditation practice by stressed family dementia caregivers can lead to improved severity of depressive symptoms, distress, coping, cognition, and quality of life compared to relaxation. This improvement is accompanied by decreases in the number of stimulated cells that express NFkB signifying improvement in inflammation. Our results need to be confirmed in a larger sample." @default.
- W2120297851 created "2016-06-24" @default.
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- W2120297851 date "2011-07-01" @default.
- W2120297851 modified "2023-09-27" @default.
- W2120297851 title "P2-388: Meditation improves depressive symptoms, coping, cognition, and inflammation in family dementia caregivers in a randomized 8-week pilot study" @default.
- W2120297851 doi "https://doi.org/10.1016/j.jalz.2011.05.1261" @default.
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