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- W2120303646 abstract "Over the past three decades the changes in sympathoadrenal function that occur with age in healthy adult humans have been systematically studied using a combination of neurochemical, neurophysiological and haemodynamic experimental approaches. The available experimental evidence indicates that tonic whole-body sympathetic nervous system (SNS) activity increases with age. The elevations in SNS activity appear to be region specific, targeting skeletal muscle and the gut, but not obviously the kidney. The SNS tone of the heart is increased, although this appears to be due in part to reduced neuronal reuptake of noradrenaline (norepinephrine). In contrast to SNS activity, tonic adrenaline (epinephrine) secretion from the adrenal medulla is markedly reduced with age. This is not reflected in plasma adrenaline concentrations because of reduced plasma clearance. Despite widely held beliefs to the contrary, sympathoadrenal responsiveness to acute stress is not exaggerated with age in healthy adults. Indeed, adrenaline release in response to acute stress is substantially attenuated in older men. The mechanisms underlying the age-associated increases in SNS activity have not been established, but our preliminary data are consistent with increased subcortical central nervous system (CNS) sympathetic drive. These changes in sympathoadrenal function with advancing age may have a number of important physiological and pathophysiological consequences for human health and disease." @default.
- W2120303646 created "2016-06-24" @default.
- W2120303646 creator A5011375886 @default.
- W2120303646 creator A5091792035 @default.
- W2120303646 date "2000-11-01" @default.
- W2120303646 modified "2023-10-17" @default.
- W2120303646 title "Human ageing and the sympathoadrenal system" @default.
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- W2120303646 cites W1853124178 @default.
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- W2120303646 cites W1951805102 @default.
- W2120303646 cites W1973089615 @default.
- W2120303646 cites W1973280875 @default.
- W2120303646 cites W1979914403 @default.
- W2120303646 cites W1984461647 @default.
- W2120303646 cites W1987591466 @default.
- W2120303646 cites W1988625353 @default.
- W2120303646 cites W1989017065 @default.
- W2120303646 cites W1989672093 @default.
- W2120303646 cites W1991383343 @default.
- W2120303646 cites W2001428635 @default.
- W2120303646 cites W2004644362 @default.
- W2120303646 cites W2008010563 @default.
- W2120303646 cites W2008460170 @default.
- W2120303646 cites W2011392057 @default.
- W2120303646 cites W2011433072 @default.
- W2120303646 cites W2024924310 @default.
- W2120303646 cites W2025479402 @default.
- W2120303646 cites W2029102628 @default.
- W2120303646 cites W2031990019 @default.
- W2120303646 cites W2032327738 @default.
- W2120303646 cites W2034673551 @default.
- W2120303646 cites W2038994119 @default.
- W2120303646 cites W2042023650 @default.
- W2120303646 cites W2042438130 @default.
- W2120303646 cites W2051462224 @default.
- W2120303646 cites W2052325698 @default.
- W2120303646 cites W2062364831 @default.
- W2120303646 cites W2063373458 @default.
- W2120303646 cites W2071526303 @default.
- W2120303646 cites W2072294014 @default.
- W2120303646 cites W2073010738 @default.
- W2120303646 cites W2073538254 @default.
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- W2120303646 cites W2084409154 @default.
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- W2120303646 cites W2099688352 @default.
- W2120303646 cites W2108094183 @default.
- W2120303646 cites W2120786809 @default.
- W2120303646 cites W2121398770 @default.
- W2120303646 cites W2121567908 @default.
- W2120303646 cites W2129125192 @default.
- W2120303646 cites W2137335941 @default.
- W2120303646 cites W2150965443 @default.
- W2120303646 cites W2153583116 @default.
- W2120303646 cites W2158394935 @default.
- W2120303646 cites W2171483164 @default.
- W2120303646 cites W2176011184 @default.
- W2120303646 cites W2185242746 @default.
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- W2120303646 cites W2312531471 @default.
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- W2120303646 cites W2326247841 @default.
- W2120303646 cites W2327384329 @default.
- W2120303646 cites W2334647866 @default.
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- W2120303646 doi "https://doi.org/10.1111/j.1469-7793.2000.00407.x" @default.
- W2120303646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270159" @default.
- W2120303646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11060120" @default.
- W2120303646 hasPublicationYear "2000" @default.
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