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- W2120316829 abstract "Abstract Six obese subjects (mean ± s.d.: 145.1 ± 16.7% of ideal body weight) were randomly assigned to a single i.v. dose either of (±)-propranolol base (0.108 mg kg−1 of ideal body weight) or of (±)-sotalol base (1.06 mg kg−1 of ideal body weight). Each subject received the other drug 7 days later. Pharmacokinetic parameters were compared with those obtained previously in non-obese control subjects. In obese subjects, the pharmacokinetic data calculated for sotalol were comparable with those measured in controls (total body clearance = 9.4 ± 2.9 L h−1; volume of distribution during the terminal phase = 79.8 ± 19.8 L or 0.9 ± 0.2 L kg−1; terminal half-life = 6.2 ± 1.6 h). For propranolol, total clearance (44.3 ± 15.9 L h−1) and volume of distribution (230.5 ± 48.2 L or 2.7 ± 0.7 L kg−1) were significantly less than control values. The terminal half-life (3.9 ± 1.1 h), was not significantly increased. These results could be explained by altered tissue blood flow and a decreased metabolic capacity of the liver in obese subjects." @default.
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- W2120316829 date "1990-05-01" @default.
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- W2120316829 title "Comparison of Propranolol and Sotalol Pharmacokinetics in Obese Subjects" @default.
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- W2120316829 doi "https://doi.org/10.1111/j.2042-7158.1990.tb05423.x" @default.
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