FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120320533> ?p ?o ?g. }

• W2120320533 endingPage "6153" @default.
• W2120320533 startingPage "6149" @default.
• W2120320533 abstract "Polysaccharides of pathogenic extracellular bacteria commonly have negatively charged groups or no charged groups at all. These molecules have been considered classic T cell-independent Ags that do not elicit cell-mediated immune responses in mice. However, bacterial polysaccharides with a zwitterionic charge motif (ZPSs), such as the capsular polysaccharides of many strains of Bacteroides fragilis, Staphylococcus aureus, and Streptococcus pneumoniae type 1 elicit potent CD4(+) T cell responses in vivo and in vitro. The cell-mediated response to ZPS depends on the presence of both positively charged and negatively charged groups on each repeating unit of the polysaccharide. In this study, we define some of the requirements for the presentation of ZPS to CD4(+) T cells. We provide evidence that direct interactions of T cells with APCs are essential for T cell activation by ZPS. Monocytes, dendritic cells, and B cells are all able to serve as APCs for ZPS-mediated T cell activation. APCs lacking MHC class II molecules do not support this activity. Furthermore, mAb to HLA-DR specifically blocks ZPS-mediated T cell activation, while mAbs to other MHC class II and class I molecules do not. Immunoprecipitation of lysates of MHC class II-expressing cells following incubation with ZPS shows binding of ZPS and HLA-DR. Electron microscopy reveals colocalization of ZPS with HLA-DR on the cell surface and in compartments of the endocytic pathway. These results indicate that MHC class II molecules expressing HLA-DR on professional APCs are required for ZPS-induced T cell activation. The implication is that binding of ZPS to HLA-DR may be required for T cell activation." @default.
• W2120320533 created "2016-06-24" @default.
• W2120320533 creator A5039350455 @default.
• W2120320533 creator A5044050032 @default.
• W2120320533 creator A5070038699 @default.
• W2120320533 creator A5074817052 @default.
• W2120320533 creator A5078964300 @default.
• W2120320533 creator A5081514135 @default.
• W2120320533 date "2002-12-01" @default.
• W2120320533 modified "2023-10-17" @default.
• W2120320533 title "Zwitterionic Polysaccharides Stimulate T Cells by MHC Class II-Dependent Interactions" @default.
• W2120320533 cites W1494785779 @default.
• W2120320533 cites W1506397040 @default.
• W2120320533 cites W1508427423 @default.
• W2120320533 cites W1525994514 @default.
• W2120320533 cites W1531675548 @default.
• W2120320533 cites W1544173786 @default.
• W2120320533 cites W1566203300 @default.
• W2120320533 cites W1576435529 @default.
• W2120320533 cites W1588885776 @default.
• W2120320533 cites W1608651908 @default.
• W2120320533 cites W1661544713 @default.
• W2120320533 cites W1823444145 @default.
• W2120320533 cites W1906135384 @default.
• W2120320533 cites W1976227897 @default.
• W2120320533 cites W1979565071 @default.
• W2120320533 cites W1979777697 @default.
• W2120320533 cites W1990548031 @default.
• W2120320533 cites W1998995307 @default.
• W2120320533 cites W2000191410 @default.
• W2120320533 cites W2026726855 @default.
• W2120320533 cites W2027679419 @default.
• W2120320533 cites W2032012524 @default.
• W2120320533 cites W2048172864 @default.
• W2120320533 cites W2058522525 @default.
• W2120320533 cites W2058910688 @default.
• W2120320533 cites W2062800186 @default.
• W2120320533 cites W2069662778 @default.
• W2120320533 cites W2075916775 @default.
• W2120320533 cites W2080956086 @default.
• W2120320533 cites W2083601518 @default.
• W2120320533 cites W2089646349 @default.
• W2120320533 cites W2119524661 @default.
• W2120320533 cites W2136455126 @default.
• W2120320533 cites W2148142599 @default.
• W2120320533 cites W2149845703 @default.
• W2120320533 cites W2161249891 @default.
• W2120320533 cites W265817920 @default.
• W2120320533 doi "https://doi.org/10.4049/jimmunol.169.11.6149" @default.
• W2120320533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12444118" @default.
• W2120320533 hasPublicationYear "2002" @default.
• W2120320533 type Work @default.
• W2120320533 sameAs 2120320533 @default.
• W2120320533 citedByCount "142" @default.
• W2120320533 countsByYear W21203205332012 @default.
• W2120320533 countsByYear W21203205332013 @default.
• W2120320533 countsByYear W21203205332014 @default.
• W2120320533 countsByYear W21203205332015 @default.
• W2120320533 countsByYear W21203205332016 @default.
• W2120320533 countsByYear W21203205332017 @default.
• W2120320533 countsByYear W21203205332018 @default.
• W2120320533 countsByYear W21203205332019 @default.
• W2120320533 countsByYear W21203205332020 @default.
• W2120320533 countsByYear W21203205332021 @default.
• W2120320533 countsByYear W21203205332022 @default.
• W2120320533 countsByYear W21203205332023 @default.
• W2120320533 crossrefType "journal-article" @default.
• W2120320533 hasAuthorship W2120320533A5039350455 @default.
• W2120320533 hasAuthorship W2120320533A5044050032 @default.
• W2120320533 hasAuthorship W2120320533A5070038699 @default.
• W2120320533 hasAuthorship W2120320533A5074817052 @default.
• W2120320533 hasAuthorship W2120320533A5078964300 @default.
• W2120320533 hasAuthorship W2120320533A5081514135 @default.
• W2120320533 hasBestOaLocation W21203205331 @default.
• W2120320533 hasConcept C170627219 @default.
• W2120320533 hasConcept C185592680 @default.
• W2120320533 hasConcept C203014093 @default.
• W2120320533 hasConcept C207936829 @default.
• W2120320533 hasConcept C2776090121 @default.
• W2120320533 hasConcept C2778814158 @default.
• W2120320533 hasConcept C67662055 @default.
• W2120320533 hasConcept C83464605 @default.
• W2120320533 hasConcept C86803240 @default.
• W2120320533 hasConcept C8891405 @default.
• W2120320533 hasConcept C95444343 @default.
• W2120320533 hasConceptScore W2120320533C170627219 @default.
• W2120320533 hasConceptScore W2120320533C185592680 @default.
• W2120320533 hasConceptScore W2120320533C203014093 @default.
• W2120320533 hasConceptScore W2120320533C207936829 @default.
• W2120320533 hasConceptScore W2120320533C2776090121 @default.
• W2120320533 hasConceptScore W2120320533C2778814158 @default.
• W2120320533 hasConceptScore W2120320533C67662055 @default.
• W2120320533 hasConceptScore W2120320533C83464605 @default.
• W2120320533 hasConceptScore W2120320533C86803240 @default.
• W2120320533 hasConceptScore W2120320533C8891405 @default.
• W2120320533 hasConceptScore W2120320533C95444343 @default.
• W2120320533 hasIssue "11" @default.
• W2120320533 hasLocation W21203205331 @default.

• next