FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120323098> ?p ?o ?g. }

• W2120323098 endingPage "7095" @default.
• W2120323098 startingPage "7088" @default.
• W2120323098 abstract "Abstract Twenty-five percent of all lung cancer cases are not attributable to smoking. Epidermal growth factor receptor (EGFR) mutations, which are involved in ∼50% of nonsmoker lung cancer, are positively correlated with responsiveness to gefitinib, and inversely correlated with smoking history. Activating EGFR mutations play a critical role in the carcinogenesis of nonsmoking-related lung cancer. To investigate the chemopreventive effects of gefitinib on nonsmoking-related lung cancer, we generated transgenic mice expressing EGFR L858R in type II pneumocytes constitutively using the surfactant protein-C promoter. The transgenic mice invariably developed atypical adenomatous hyperplasia at age 4 weeks and multifocal adenocarcinoma of varying sizes at age 7 weeks. Notably, the expression levels of phosphorylated and total ErbB2, ErbB3, and thyroid transcription factor-1 were elevated in the transgenic mice compared with wild-type controls at age 3 weeks. Administration of gefitinib to 3-week-old transgenic mice for 1 week before carcinogenesis reduced the amount of phosphorylated EGFR in the lungs of the mice to the baseline level. Gefitinib (5 mg/kg/d; n = 5, 5, and 15) or vehicle (n = 5, 5, and 15) was administered to transgenic mice from age 3 to 8, 13, and 18 weeks, respectively. The numbers of lung tumors in the control and gefitinib-treated groups were 1.75, 5.8, 10.2, and 0 (P &lt; 0.05), respectively. No fatal toxic events occurred in either group, and gefitinib inhibited tumorigenesis completely in this mouse model. These results suggest the utility of molecular targeted chemoprevention against nonsmoking-related lung cancer. [Cancer Res 2009;69(17):7088–95]" @default.
• W2120323098 created "2016-06-24" @default.
• W2120323098 creator A5001897650 @default.
• W2120323098 creator A5002122857 @default.
• W2120323098 creator A5002407044 @default.
• W2120323098 creator A5007888883 @default.
• W2120323098 creator A5015378186 @default.
• W2120323098 creator A5035360618 @default.
• W2120323098 creator A5050389295 @default.
• W2120323098 creator A5056975051 @default.
• W2120323098 creator A5066700160 @default.
• W2120323098 creator A5074447395 @default.
• W2120323098 creator A5090915905 @default.
• W2120323098 date "2009-08-31" @default.
• W2120323098 modified "2023-10-14" @default.
• W2120323098 title "Chemopreventive Effects of Gefitinib on Nonsmoking-Related Lung Tumorigenesis in Activating Epidermal Growth Factor Receptor Transgenic Mice" @default.
• W2120323098 cites W1931438814 @default.
• W2120323098 cites W1967728016 @default.
• W2120323098 cites W1974027176 @default.
• W2120323098 cites W1984925718 @default.
• W2120323098 cites W1985440048 @default.
• W2120323098 cites W1990386577 @default.
• W2120323098 cites W1997802996 @default.
• W2120323098 cites W1998971866 @default.
• W2120323098 cites W2011192758 @default.
• W2120323098 cites W2020830322 @default.
• W2120323098 cites W2025358708 @default.
• W2120323098 cites W2031248807 @default.
• W2120323098 cites W2035263975 @default.
• W2120323098 cites W2037873277 @default.
• W2120323098 cites W2041992600 @default.
• W2120323098 cites W2042103473 @default.
• W2120323098 cites W2043696829 @default.
• W2120323098 cites W2047100184 @default.
• W2120323098 cites W2047414076 @default.
• W2120323098 cites W2065364771 @default.
• W2120323098 cites W2070011883 @default.
• W2120323098 cites W2089750734 @default.
• W2120323098 cites W2093269827 @default.
• W2120323098 cites W2096605111 @default.
• W2120323098 cites W2104300284 @default.
• W2120323098 cites W2110675408 @default.
• W2120323098 cites W2111109297 @default.
• W2120323098 cites W2120181506 @default.
• W2120323098 cites W2121389354 @default.
• W2120323098 cites W2122712858 @default.
• W2120323098 cites W2126181231 @default.
• W2120323098 cites W2128083919 @default.
• W2120323098 cites W2128953017 @default.
• W2120323098 cites W2129774558 @default.
• W2120323098 cites W2130383653 @default.
• W2120323098 cites W2132175919 @default.
• W2120323098 cites W2133171814 @default.
• W2120323098 cites W2134964552 @default.
• W2120323098 cites W2138960985 @default.
• W2120323098 cites W2140775102 @default.
• W2120323098 cites W2143171062 @default.
• W2120323098 cites W2143859186 @default.
• W2120323098 cites W2148174696 @default.
• W2120323098 cites W2165119042 @default.
• W2120323098 cites W2171313739 @default.
• W2120323098 cites W2171924781 @default.
• W2120323098 doi "https://doi.org/10.1158/0008-5472.can-08-4205" @default.
• W2120323098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19690148" @default.
• W2120323098 hasPublicationYear "2009" @default.
• W2120323098 type Work @default.
• W2120323098 sameAs 2120323098 @default.
• W2120323098 citedByCount "22" @default.
• W2120323098 countsByYear W21203230982012 @default.
• W2120323098 countsByYear W21203230982013 @default.
• W2120323098 countsByYear W21203230982014 @default.
• W2120323098 countsByYear W21203230982015 @default.
• W2120323098 countsByYear W21203230982016 @default.
• W2120323098 countsByYear W21203230982019 @default.
• W2120323098 countsByYear W21203230982021 @default.
• W2120323098 countsByYear W21203230982022 @default.
• W2120323098 countsByYear W21203230982023 @default.
• W2120323098 crossrefType "journal-article" @default.
• W2120323098 hasAuthorship W2120323098A5001897650 @default.
• W2120323098 hasAuthorship W2120323098A5002122857 @default.
• W2120323098 hasAuthorship W2120323098A5002407044 @default.
• W2120323098 hasAuthorship W2120323098A5007888883 @default.
• W2120323098 hasAuthorship W2120323098A5015378186 @default.
• W2120323098 hasAuthorship W2120323098A5035360618 @default.
• W2120323098 hasAuthorship W2120323098A5050389295 @default.
• W2120323098 hasAuthorship W2120323098A5056975051 @default.
• W2120323098 hasAuthorship W2120323098A5066700160 @default.
• W2120323098 hasAuthorship W2120323098A5074447395 @default.
• W2120323098 hasAuthorship W2120323098A5090915905 @default.
• W2120323098 hasBestOaLocation W21203230982 @default.
• W2120323098 hasConcept C102230213 @default.
• W2120323098 hasConcept C104317684 @default.
• W2120323098 hasConcept C121608353 @default.
• W2120323098 hasConcept C126322002 @default.
• W2120323098 hasConcept C134018914 @default.
• W2120323098 hasConcept C141035611 @default.
• W2120323098 hasConcept C2776256026 @default.
• W2120323098 hasConcept C2779438470 @default.

• next