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• W2120342014 abstract "<h3>Objective:</h3> To assess the association between male circumcision and <i>Neisseria gonorrhoeae</i>, <i>Chlamydia trachomatis</i> and <i>Trichomonas vaginalis</i> using data from a male circumcision randomised controlled trial. <h3>Methods:</h3> We used data collected during the male circumcision trial conducted in Orange Farm (South Africa) among men aged 18–24 years. Altogether, 1767 urine samples collected during the final follow-up visit were analysed using PCR. Prevalence of <i>N gonorrhoeae</i>, <i>C trachomatis</i> and <i>T vaginalis</i> was assessed as a function of male circumcision using odds ratios (OR) given by univariate and multivariate logistic regression. <h3>Results:</h3> In an intention-to-treat analysis, prevalence of <i>N gonorrhoeae</i>, <i>C trachomatis</i> and <i>T vaginalis</i> among intervention and control groups were 10.0% versus 10.3% (OR 0.97; p = 0.84), 2.1% versus 3.6% (OR 0.58; p = 0.065) and 1.7% versus 3.1% (OR 0.54; p = 0.062), respectively. The association between <i>T vaginalis</i> and male circumcision remained borderline when controlling for age, ethnic group, number of lifetime partners, marital status, condom use and HIV status (AOR 0.48; p = 0.069). In the as-treated analysis, this association became significant (OR 0.49, p = 0.030; AOR 0.41, p = 0.030). <h3>Conclusions:</h3> This study demonstrates for the first time that male circumcision reduces <i>T vaginalis</i> infection among men. This finding explains why women with circumcised partners are less at risk for <i>T vaginalis</i> infection than other women. The protective effect on <i>T vaginalis</i> is an additional argument to recommend male circumcision in Africa where it is acceptable. <h3>Trial registration number:</h3> NCT00122525." @default.
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• W2120342014 date "2008-11-12" @default.
• W2120342014 modified "2023-09-27" @default.
• W2120342014 title "Male circumcision and Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis: observations after a randomised controlled trial for HIV prevention" @default.
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• W2120342014 doi "https://doi.org/10.1136/sti.2008.032334" @default.
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