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- W2120351567 abstract "The regulation of ribosomal protein (RP) gene transcription is tightly linked to the nutrient status of the cell and is under the control of metabolic signaling pathways. In Saccharomyces cerevisiae several transcriptional activators mediate efficient RP gene transcription during logarithmic growth and dissociate from RP gene promoters upon nutrient limitation. Repression of RP gene transcription appears to be regulated predominantly by posttranslational modification and cellular localization of transcriptional activators. We report here that one of these factors, Sfp1, is degraded by the proteasome and that the proteasome activator Blm10 is required for regulated Sfp1 degradation. Loss of Blm10 results in the stabilization and increased nuclear abundance of Sfp1 during nutrient limitation, increased transcription of RP genes, increased levels of RPs, and decreased rapamycin-induced repression of RP genes. Thus we conclude that proteasomal degradation of Sfp1 is mediated by Blm10 and contributes to the repression of ribosome biogenesis under nutrient depletion." @default.
- W2120351567 created "2016-06-24" @default.
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- W2120351567 creator A5065115511 @default.
- W2120351567 creator A5087841724 @default.
- W2120351567 date "2011-03-01" @default.
- W2120351567 modified "2023-09-27" @default.
- W2120351567 title "Proteasomal degradation of Sfp1 contributes to the repression of ribosome biogenesis during starvation and is mediated by the proteasome activator Blm10" @default.
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- W2120351567 doi "https://doi.org/10.1091/mbc.e10-04-0352" @default.
- W2120351567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3046052" @default.
- W2120351567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21209318" @default.
- W2120351567 hasPublicationYear "2011" @default.
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