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- W2120351746 abstract "Determination of rearrangements in ALK gene in patients with non-small cell lung cancer (NSCLC), proposed as a mandatory procedure in most current international guidelines for the diagnosis and treatment of cancer. The aim of the study was to conduct a test by fluorescent hybridization in situ (FISH) of translocations involving ALK gene in patients referred for testing for EGFR gene mutations in the framework of the Society of oncologists-chemotherapeutists Improvement of molecular genetic diagnosis in order to improve the efficiency of anticancer treatment» www.cancergenome.ru . Successful tests conducted in 189 out of 200 patients with NSCLC without mutations EGFR. There 12 positive tests (6.3%). The dependence of the frequency of detection of gene rearrangements of the ALK histological forms of cancer, smoking status and age of the patient was shown. The efficiency of wide FISH testing for ALK gene rearrangements in patients with glandular histological types of NSCLC was confirmed." @default.
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- W2120351746 date "2015-05-20" @default.
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- W2120351746 title "Determination of rearrangements in ALK gene in selected russian population of patients with non-small cell lung cancer" @default.
- W2120351746 doi "https://doi.org/10.18027/2224-5057-2013-3-3-9" @default.
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