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- W2120355178 abstract "Kaposi's sarcoma-associated herpesvirus (KSHV) lytic switch protein, Rta, is a ligand-independent inducer of the Notch signal transduction pathway, and KSHV cannot reactivate from latency in cells null for the Notch target protein RBP-Jk. Here we show that Rta promotes DNA binding of RBP-Jk, a mechanism that is fundamentally different from that established for the RBP-Jk-activating proteins, Notch intracellular domain (NICD) and Epstein-Barr virus EBNA2. Although constitutively active RBP-Jk and NICD do not transactivate KSHV promoters independently, cotransfection of an Rta mutant lacking its transactivation domain robustly restores transcriptional activation. Cooperation requires intact DNA binding sites for Rta and RBP-Jk and trimeric complex formation between the three molecules in vitro. In infected cells, RBP-Jk is virtually undetectable on a series of viral and cellular promoters during KSHV latency but is significantly enriched following Rta expression during viral reactivation. Accordingly, Rta, but not EBNA2 and NICD, reactivates the complete viral lytic cycle." @default.
- W2120355178 created "2016-06-24" @default.
- W2120355178 creator A5004879699 @default.
- W2120355178 creator A5006368261 @default.
- W2120355178 creator A5061176250 @default.
- W2120355178 creator A5065390531 @default.
- W2120355178 creator A5067786442 @default.
- W2120355178 creator A5076764205 @default.
- W2120355178 creator A5081381546 @default.
- W2120355178 creator A5087341141 @default.
- W2120355178 date "2006-10-01" @default.
- W2120355178 modified "2023-10-16" @default.
- W2120355178 title "Kaposi's Sarcoma-Associated Herpesvirus Lytic Switch Protein Stimulates DNA Binding of RBP-Jk/CSL To Activate the Notch Pathway" @default.
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