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- W2120362241 abstract "2,6-Dichloro-3-(trifluoromethyl)pyridine 3 was used to develop a six-step preparation of 7-amino-4-oxo-6-(trifluoromethyl)naphthyridines. The CF3 group deactivated the pyridine ring towards both nucleophiles and electrophiles. A new reagent for pyridone annulation, the aminomethylidenemalonate anion, is described, along with several strategies to manipulate the electron density of substituted pyridines." @default.
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- W2120362241 date "1990-09-01" @default.
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- W2120362241 title "Synthesis of 7-amino-1,4-dihydro-4-oxo-6-(trifluoromethyl)-1,8-naphthyridines. The use of methylidenemalonate as an activating group and a sulfur assisted cyclization" @default.
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- W2120362241 doi "https://doi.org/10.1002/jhet.5570270602" @default.
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