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- W2120363422 abstract "Summary. H. pylori is one of the most common infections worldwide. It colonizes about 60% of the world's population, causing gastritis, peptic ulcer disease and is strongly associated with gastric carcinoma and gastric lymphoma.The prevalence of H. pylori infection is associated with socio-economic status. H. pylori, by direct contact and elaboration of enzymes and putative citotoxins, can directly injure gastric cells and may be directly responsible for the majority of gastric cell damage found in infected persons. There is genotypic variation between H. pylori strains. Several genes have been identified that may play a role in the pathogenicity of H. pylori (vacA, cagA, iceA). The numerous tests are available to diagnose H. pylori. Histology, culture and urease test are classified in invasive tests, but serology and urea breath test in non-invasive tests. Urea breath test is the best test to confirm eradication of H. pylori infection. Maastricht guidelines strongly recommended eradication therapy for unequivocally diagnosed H. pylori positive patients with: duodenal or gastric ulcer, low grade MALT gastric lymphoma, gastritis with severe macro- or microscopic changes, and after resection of early gastric cancer. In recent years, 1-week triple therapies including a proton pump inhibitor and two antibiotics: clarithromycin (or another macrolide), a nitroimidazole (metronidazole or tinidazole) or amoxycillin have been accepted as the standard therapeutic approach. An effective , safe vaccine that prevents infection with H. pylori would clearly be the optimal intervention strategy in the future in those countries where gastric cancer remains a major problem. Within the next five years, a few vaccines will most likely be tested in humans. Our concerns as to how we best manage H. pylori infection will be eliminated, if the final vaccines are effective both prophylactically and therapeutically." @default.
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- W2120363422 date "2000-01-01" @default.
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- W2120363422 title "HELICOBACTER PYLORI AT THE END OF THE SECOND MILLENNIUM" @default.
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