FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120363969> ?p ?o ?g. }

• W2120363969 endingPage "940" @default.
• W2120363969 startingPage "927" @default.
• W2120363969 abstract "A technique of constant-flow perfusion of isolated segments of dog intestinal arteries was used to investigate the role of calcium in contractile excitation of vascular smooth muscle by epinephrine and potassium. Contractile responses of the arterial muscle to epinephrine, perfused at constant concentration, and to potassium, perfused at high concentration, were both promptly prevented by calcium deionizing accomplished by simultaneous perfusion with solutions containing ethylenediaminetetraacetate (EDTA) for the chelation of available calcium ions. Potassium-induced muscular contracture was removed in a few minutes and epinephrine-induced contractions of potassium-depolarized muscle were soon prevented by perfusion with solutions containing ionic species of EDTA which chelated calcium ions. In muscle depolarized by potassium and calcium deionized by perfusion with solution containing MgK 2 EDTA, the contractile responses to epinephrine were immediately restored by combined perfusate injection of calcium ion and epinephrine. Injections of isosmotic calcium chloride solution of subthreshold or threshold contractile strength, when the artery had been perfused with sodium chloride-rich solution and the muscle had been relaxed, produced much greater contractions during both potassium and epinephrine excitation. The contractions from injected calcium chloride solution were increased by epinephrine excitation of muscle already depolarized by the external application of potassium sulfate, as they were in the previously polarized or resting muscle excited by epinephrine. The thesis is advanced that the relative muscular contractions induced by standard injected volumes of isosmotic calcium chloride solution were a relative index of the calcium influx and calcium permeability of the arterial smooth muscle cells in the various experimental conditions prevailing. Equimolar injections of isosmotic calcium iodide solution produced greater muscular contractions than did injections of isosmotic calcium chloride solution. The possibility is discussed that transmembranous passage of calcium into vascular muscle cells occurs significantly in the form of associated ion pairs. A dual effect of potassium on vascular smooth muscle behavior was observed in that a previously contractile-inducing amount of injected potassium exerted a relaxing effect on the arterial segment perfused with low-potassium solution when the muscle was contracted by epinephrine. It is concluded that: (a) calcium is essentially involved in excitation-contraction coupling of vascular smooth muscle; (b) the calcium permeability and calcium influx of vascular smooth muscle is greatly increased during both epinephrine and potassium excitation of the muscle cells, and epinephrine accomplishes these calcium changes even in muscle already depolarized by potassium; (c) adrenergic neurohormones exert their vasoexcitatory contractile effect by a membrane reaction which is basically nonelectrical and which primarily triggers an increased permeability and influx of calcium into the vascular myoplasm; and (d) the migrated calcium activates intracellularly the myoplasmic events of vascular smooth muscle contraction." @default.
• W2120363969 created "2016-06-24" @default.
• W2120363969 creator A5082612591 @default.
• W2120363969 date "1962-12-01" @default.
• W2120363969 modified "2023-10-16" @default.
• W2120363969 title "Role of Calcium in Contractile Excitation of Vascular Smooth Muscle by Epinephrine and Potassium" @default.
• W2120363969 cites W1458144057 @default.
• W2120363969 cites W1506004946 @default.
• W2120363969 cites W1523938864 @default.
• W2120363969 cites W1590022473 @default.
• W2120363969 cites W1605610190 @default.
• W2120363969 cites W1959754924 @default.
• W2120363969 cites W1969323694 @default.
• W2120363969 cites W1972659966 @default.
• W2120363969 cites W1976172716 @default.
• W2120363969 cites W2006520697 @default.
• W2120363969 cites W2012180657 @default.
• W2120363969 cites W2030271041 @default.
• W2120363969 cites W2033163845 @default.
• W2120363969 cites W2040804886 @default.
• W2120363969 cites W2049987350 @default.
• W2120363969 cites W2050009844 @default.
• W2120363969 cites W2052429900 @default.
• W2120363969 cites W2053315663 @default.
• W2120363969 cites W2059217719 @default.
• W2120363969 cites W2062904488 @default.
• W2120363969 cites W2064701261 @default.
• W2120363969 cites W2079572940 @default.
• W2120363969 cites W2087517892 @default.
• W2120363969 cites W2104896617 @default.
• W2120363969 cites W2106194582 @default.
• W2120363969 cites W2135645464 @default.
• W2120363969 cites W2166360170 @default.
• W2120363969 cites W2177020591 @default.
• W2120363969 cites W2268506238 @default.
• W2120363969 cites W2290302665 @default.
• W2120363969 cites W2319505035 @default.
• W2120363969 cites W2346808036 @default.
• W2120363969 cites W2588320109 @default.
• W2120363969 cites W3021802079 @default.
• W2120363969 cites W30572657 @default.
• W2120363969 cites W2236607157 @default.
• W2120363969 doi "https://doi.org/10.1161/01.res.11.6.927" @default.
• W2120363969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13999262" @default.
• W2120363969 hasPublicationYear "1962" @default.
• W2120363969 type Work @default.
• W2120363969 sameAs 2120363969 @default.
• W2120363969 citedByCount "60" @default.
• W2120363969 countsByYear W21203639692016 @default.
• W2120363969 countsByYear W21203639692022 @default.
• W2120363969 countsByYear W21203639692023 @default.
• W2120363969 crossrefType "journal-article" @default.
• W2120363969 hasAuthorship W2120363969A5082612591 @default.
• W2120363969 hasBestOaLocation W21203639691 @default.
• W2120363969 hasConcept C12554922 @default.
• W2120363969 hasConcept C126322002 @default.
• W2120363969 hasConcept C134018914 @default.
• W2120363969 hasConcept C146957229 @default.
• W2120363969 hasConcept C178790620 @default.
• W2120363969 hasConcept C185592680 @default.
• W2120363969 hasConcept C2775859304 @default.
• W2120363969 hasConcept C2779395532 @default.
• W2120363969 hasConcept C2992686903 @default.
• W2120363969 hasConcept C517785266 @default.
• W2120363969 hasConcept C519063684 @default.
• W2120363969 hasConcept C71924100 @default.
• W2120363969 hasConcept C86803240 @default.
• W2120363969 hasConceptScore W2120363969C12554922 @default.
• W2120363969 hasConceptScore W2120363969C126322002 @default.
• W2120363969 hasConceptScore W2120363969C134018914 @default.
• W2120363969 hasConceptScore W2120363969C146957229 @default.
• W2120363969 hasConceptScore W2120363969C178790620 @default.
• W2120363969 hasConceptScore W2120363969C185592680 @default.
• W2120363969 hasConceptScore W2120363969C2775859304 @default.
• W2120363969 hasConceptScore W2120363969C2779395532 @default.
• W2120363969 hasConceptScore W2120363969C2992686903 @default.
• W2120363969 hasConceptScore W2120363969C517785266 @default.
• W2120363969 hasConceptScore W2120363969C519063684 @default.
• W2120363969 hasConceptScore W2120363969C71924100 @default.
• W2120363969 hasConceptScore W2120363969C86803240 @default.
• W2120363969 hasIssue "6" @default.
• W2120363969 hasLocation W21203639691 @default.
• W2120363969 hasLocation W21203639692 @default.
• W2120363969 hasOpenAccess W2120363969 @default.
• W2120363969 hasPrimaryLocation W21203639691 @default.
• W2120363969 hasRelatedWork W2002786746 @default.
• W2120363969 hasRelatedWork W2037107047 @default.
• W2120363969 hasRelatedWork W2097167903 @default.
• W2120363969 hasRelatedWork W2141044366 @default.
• W2120363969 hasRelatedWork W2206715558 @default.
• W2120363969 hasRelatedWork W2301336459 @default.
• W2120363969 hasRelatedWork W2323677139 @default.
• W2120363969 hasRelatedWork W2408985580 @default.
• W2120363969 hasRelatedWork W3016559957 @default.
• W2120363969 hasRelatedWork W3028339196 @default.
• W2120363969 hasVolume "11" @default.
• W2120363969 isParatext "false" @default.
• W2120363969 isRetracted "false" @default.

• next