FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120366984> ?p ?o ?g. }

• W2120366984 endingPage "169" @default.
• W2120366984 startingPage "155" @default.
• W2120366984 abstract "Cell physiology is regulated along the 24-hour timescale by a circadian clock, which is comprised of interconnected molecular loops involving at least nine genes. The cellular clocks are coordinated by the suprachiasmatic nucleus, a hypothalamic pacemaker that also helps the organism adjust to environmental cycles. The rest-activity rhythm is a reliable marker of the circadian system function in both rodents and humans. This circadian organization is responsible for predictable changes in the tolerability and efficacy of anticancer agents, and possibly also may be involved in tumor promotion or growth.Expected least toxic times of chemotherapy were extrapolated from experimental models to human subjects with reference to the rest-activity cycle. The clinical relevance of the chronotherapy principle (i.e., treatment administration as a function of rhythms) has been investigated previously in randomized multicenter trials.In the current study, chronotherapeutic schedules were used to safely document activity of the combination of oxaliplatin, 5-fluorouracil, and leucovorin against metastatic colorectal carcinoma and to establish new medicosurgical management for this disease, and were reported to result in unprecedented long-term survival.Chronotherapy concepts appear to offer further potential to improve current cancer treatment options as well as to optimize the development of new anticancer or supportive agents." @default.
• W2120366984 created "2016-06-24" @default.
• W2120366984 creator A5012970552 @default.
• W2120366984 creator A5078259466 @default.
• W2120366984 date "2002-12-18" @default.
• W2120366984 modified "2023-10-08" @default.
• W2120366984 title "Cancer chronotherapy: Principles, applications, and perspectives" @default.
• W2120366984 cites W1661083499 @default.
• W2120366984 cites W1911412315 @default.
• W2120366984 cites W1914884493 @default.
• W2120366984 cites W1969659602 @default.
• W2120366984 cites W1971561311 @default.
• W2120366984 cites W1972635846 @default.
• W2120366984 cites W1975150591 @default.
• W2120366984 cites W1983978564 @default.
• W2120366984 cites W1985826300 @default.
• W2120366984 cites W1986608768 @default.
• W2120366984 cites W1992494470 @default.
• W2120366984 cites W1993900486 @default.
• W2120366984 cites W1994710209 @default.
• W2120366984 cites W1996167718 @default.
• W2120366984 cites W2001341743 @default.
• W2120366984 cites W2013102707 @default.
• W2120366984 cites W2014668074 @default.
• W2120366984 cites W2016700313 @default.
• W2120366984 cites W2020215928 @default.
• W2120366984 cites W2022454304 @default.
• W2120366984 cites W2024464640 @default.
• W2120366984 cites W2040957483 @default.
• W2120366984 cites W2042327275 @default.
• W2120366984 cites W2044118975 @default.
• W2120366984 cites W2046577583 @default.
• W2120366984 cites W2054652476 @default.
• W2120366984 cites W2057287967 @default.
• W2120366984 cites W2058590829 @default.
• W2120366984 cites W2059234543 @default.
• W2120366984 cites W2065260877 @default.
• W2120366984 cites W2065982243 @default.
• W2120366984 cites W2067877787 @default.
• W2120366984 cites W2076423158 @default.
• W2120366984 cites W2084699449 @default.
• W2120366984 cites W2091427633 @default.
• W2120366984 cites W2101841902 @default.
• W2120366984 cites W2117500868 @default.
• W2120366984 cites W2129502482 @default.
• W2120366984 cites W2133960000 @default.
• W2120366984 cites W2139844513 @default.
• W2120366984 cites W2148434849 @default.
• W2120366984 cites W2150081842 @default.
• W2120366984 cites W2152486489 @default.
• W2120366984 cites W2162313061 @default.
• W2120366984 cites W2163527944 @default.
• W2120366984 cites W2169014327 @default.
• W2120366984 cites W2171680834 @default.
• W2120366984 cites W2222979086 @default.
• W2120366984 cites W2229860171 @default.
• W2120366984 cites W2232008177 @default.
• W2120366984 cites W2263607972 @default.
• W2120366984 cites W2296279407 @default.
• W2120366984 cites W2332704213 @default.
• W2120366984 cites W265117922 @default.
• W2120366984 cites W2887519251 @default.
• W2120366984 cites W4237703943 @default.
• W2120366984 cites W76050853 @default.
• W2120366984 doi "https://doi.org/10.1002/cncr.11040" @default.
• W2120366984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12910534" @default.
• W2120366984 hasPublicationYear "2002" @default.
• W2120366984 type Work @default.
• W2120366984 sameAs 2120366984 @default.
• W2120366984 citedByCount "217" @default.
• W2120366984 countsByYear W21203669842012 @default.
• W2120366984 countsByYear W21203669842013 @default.
• W2120366984 countsByYear W21203669842014 @default.
• W2120366984 countsByYear W21203669842015 @default.
• W2120366984 countsByYear W21203669842016 @default.
• W2120366984 countsByYear W21203669842017 @default.
• W2120366984 countsByYear W21203669842018 @default.
• W2120366984 countsByYear W21203669842019 @default.
• W2120366984 countsByYear W21203669842020 @default.
• W2120366984 countsByYear W21203669842021 @default.
• W2120366984 countsByYear W21203669842022 @default.
• W2120366984 countsByYear W21203669842023 @default.
• W2120366984 crossrefType "journal-article" @default.
• W2120366984 hasAuthorship W2120366984A5012970552 @default.
• W2120366984 hasAuthorship W2120366984A5078259466 @default.
• W2120366984 hasConcept C121446783 @default.
• W2120366984 hasConcept C121608353 @default.
• W2120366984 hasConcept C126322002 @default.
• W2120366984 hasConcept C143998085 @default.
• W2120366984 hasConcept C169760540 @default.
• W2120366984 hasConcept C187765855 @default.
• W2120366984 hasConcept C197934379 @default.
• W2120366984 hasConcept C2778375690 @default.
• W2120366984 hasConcept C2779134260 @default.
• W2120366984 hasConcept C2779317972 @default.
• W2120366984 hasConcept C2779910239 @default.
• W2120366984 hasConcept C2780962732 @default.
• W2120366984 hasConcept C2911092814 @default.

• next