Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120373753> ?p ?o ?g. }
- W2120373753 endingPage "8" @default.
- W2120373753 startingPage "3954" @default.
- W2120373753 abstract "The binding of epidermal growth factor, asialoorosomucoid, and apoprotein E-rich lipoproteins to isolated hepatocytes was investigated at various time intervals during the step-by-step development of liver cancer in rats. The degree of binding of the three ligands showed a progressive reduction in early persistent and late persistent putative preneoplastic hepatocyte nodules. This was further decreased in hepatocytes isolated from unequivocal hepatocellular carcinomas. Regenerating liver hepatocytes bound lesser amounts of epidermal growth factor and asialoorosomucoid than did hepatocytes from control resting liver but increased amounts of apoprotein E-rich lipoproteins. The progressive decrease in ligand binding during the precancerous phase of hepatocarcinogenesis, the nodule-to-cancer sequence, may render nodules less responsive to the influences of their external environments." @default.
- W2120373753 created "2016-06-24" @default.
- W2120373753 creator A5001987906 @default.
- W2120373753 creator A5002778886 @default.
- W2120373753 creator A5087808006 @default.
- W2120373753 date "1987-08-01" @default.
- W2120373753 modified "2023-10-18" @default.
- W2120373753 title "Patterns of ligand binding to normal, regenerating, preneoplastic, and neoplastic rat hepatocytes." @default.
- W2120373753 cites W1508039723 @default.
- W2120373753 cites W1528863972 @default.
- W2120373753 cites W1540260842 @default.
- W2120373753 cites W1575818884 @default.
- W2120373753 cites W1580023435 @default.
- W2120373753 cites W1593043870 @default.
- W2120373753 cites W1616594328 @default.
- W2120373753 cites W1634194742 @default.
- W2120373753 cites W1748902457 @default.
- W2120373753 cites W1775749144 @default.
- W2120373753 cites W1799453656 @default.
- W2120373753 cites W1898775242 @default.
- W2120373753 cites W1926137208 @default.
- W2120373753 cites W1936985502 @default.
- W2120373753 cites W1948934274 @default.
- W2120373753 cites W1964258820 @default.
- W2120373753 cites W1971032832 @default.
- W2120373753 cites W1977665282 @default.
- W2120373753 cites W1978236215 @default.
- W2120373753 cites W1980676882 @default.
- W2120373753 cites W1986930204 @default.
- W2120373753 cites W1988761203 @default.
- W2120373753 cites W1989652618 @default.
- W2120373753 cites W1996241166 @default.
- W2120373753 cites W2004184281 @default.
- W2120373753 cites W2005669461 @default.
- W2120373753 cites W2011704779 @default.
- W2120373753 cites W2013221314 @default.
- W2120373753 cites W2014398730 @default.
- W2120373753 cites W2016568386 @default.
- W2120373753 cites W2019708183 @default.
- W2120373753 cites W2028463777 @default.
- W2120373753 cites W2030385738 @default.
- W2120373753 cites W2032731208 @default.
- W2120373753 cites W2034021645 @default.
- W2120373753 cites W2034185792 @default.
- W2120373753 cites W2041351776 @default.
- W2120373753 cites W2045433342 @default.
- W2120373753 cites W2060880435 @default.
- W2120373753 cites W2070256254 @default.
- W2120373753 cites W2070501693 @default.
- W2120373753 cites W2080580789 @default.
- W2120373753 cites W2095520922 @default.
- W2120373753 cites W2098920984 @default.
- W2120373753 cites W2100837269 @default.
- W2120373753 cites W2101108802 @default.
- W2120373753 cites W2112237035 @default.
- W2120373753 cites W2116630730 @default.
- W2120373753 cites W2121241773 @default.
- W2120373753 cites W2124858049 @default.
- W2120373753 cites W2126807203 @default.
- W2120373753 cites W2130552489 @default.
- W2120373753 cites W2132440341 @default.
- W2120373753 cites W2132635830 @default.
- W2120373753 cites W2134967094 @default.
- W2120373753 cites W2135503869 @default.
- W2120373753 cites W2137056521 @default.
- W2120373753 cites W2137716547 @default.
- W2120373753 cites W2145217590 @default.
- W2120373753 cites W2155135174 @default.
- W2120373753 cites W2169311046 @default.
- W2120373753 cites W2218760274 @default.
- W2120373753 cites W2257648472 @default.
- W2120373753 cites W2267588421 @default.
- W2120373753 cites W2307563242 @default.
- W2120373753 cites W2395101187 @default.
- W2120373753 cites W2414538834 @default.
- W2120373753 cites W2440648948 @default.
- W2120373753 cites W2107196534 @default.
- W2120373753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3038301" @default.
- W2120373753 hasPublicationYear "1987" @default.
- W2120373753 type Work @default.
- W2120373753 sameAs 2120373753 @default.
- W2120373753 citedByCount "10" @default.
- W2120373753 crossrefType "journal-article" @default.
- W2120373753 hasAuthorship W2120373753A5001987906 @default.
- W2120373753 hasAuthorship W2120373753A5002778886 @default.
- W2120373753 hasAuthorship W2120373753A5087808006 @default.
- W2120373753 hasConcept C116569031 @default.
- W2120373753 hasConcept C121608353 @default.
- W2120373753 hasConcept C126322002 @default.
- W2120373753 hasConcept C134018914 @default.
- W2120373753 hasConcept C142724271 @default.
- W2120373753 hasConcept C153911025 @default.
- W2120373753 hasConcept C170493617 @default.
- W2120373753 hasConcept C171056886 @default.
- W2120373753 hasConcept C185592680 @default.
- W2120373753 hasConcept C202751555 @default.
- W2120373753 hasConcept C2776200302 @default.
- W2120373753 hasConcept C2776231280 @default.