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• W2120384002 abstract "BackgroundViruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear.ObjectiveWe sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children.MethodsSixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed.ResultsHuman rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms.ConclusionThe detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms. Viruses are frequently associated with acute exacerbations of asthma, but the extent to which they contribute to the level of day-to-day symptom control is less clear. We sought to explore the relationship between viral infections, host and environmental factors, and respiratory symptoms in children. Sixty-seven asthmatic children collected samples twice weekly for an average of 10 weeks. These included nasal wash fluid and exhaled breath for PCR-based detection of viral RNA, lung function measurements, and records of medication use and asthma and respiratory symptoms in the previous 3 days. Atopy, mite allergen exposure, and vitamin D levels were also measured. Mixed-model regression analyses were performed. Human rhinoviruses (hRVs) were detected in 25.5% of 1232 nasal samples and 11.5% of breath samples. Non-hRV viruses were detected in less than 3% of samples. hRV in nasal samples was associated with asthma symptoms (cough and phlegm: odds ratio = 2.0; 95% CI = 1.4-2.86, P = .0001; wheeze and chest tightness: odds ratio = 2.34, 95% CI = 1.55-3.52, P < .0001) and with cold symptoms, as reported concurrently with sampling and 3 to 4 days later. No differences were found between the 3 hRV genotypes (hRV-A, hRV-B, and hRV-C) in symptom risk. A history of inhaled corticosteroid use, but not atopic status, mite allergen exposure, or vitamin D levels, modified the association between viruses and asthma symptoms. The detection of nasal hRV was associated with a significantly increased risk of day-to-day asthma symptoms in children. Host, virus genotype, and environmental factors each had only a small or no effect on the relationship of viral infections to asthma symptoms." @default.
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• W2120384002 date "2015-03-01" @default.
• W2120384002 modified "2023-10-14" @default.
• W2120384002 title "Rhinoviruses significantly affect day-to-day respiratory symptoms of children with asthma" @default.
• W2120384002 cites W1513371162 @default.
• W2120384002 cites W1774644700 @default.
• W2120384002 cites W1893470333 @default.
• W2120384002 cites W1961223602 @default.
• W2120384002 cites W1964779747 @default.
• W2120384002 cites W1970703972 @default.
• W2120384002 cites W1972784839 @default.
• W2120384002 cites W1975184470 @default.
• W2120384002 cites W1978053539 @default.
• W2120384002 cites W1979580583 @default.
• W2120384002 cites W1981489157 @default.
• W2120384002 cites W1986115469 @default.
• W2120384002 cites W1986741472 @default.
• W2120384002 cites W199101596 @default.
• W2120384002 cites W1992600082 @default.
• W2120384002 cites W1992879614 @default.
• W2120384002 cites W1993289630 @default.
• W2120384002 cites W2006271913 @default.
• W2120384002 cites W2010962160 @default.
• W2120384002 cites W2021146768 @default.
• W2120384002 cites W2031494108 @default.
• W2120384002 cites W2043770158 @default.
• W2120384002 cites W2046864350 @default.
• W2120384002 cites W2055317095 @default.
• W2120384002 cites W2057228502 @default.
• W2120384002 cites W2057539362 @default.
• W2120384002 cites W2060053138 @default.
• W2120384002 cites W2064405701 @default.
• W2120384002 cites W2064985524 @default.
• W2120384002 cites W2068966334 @default.
• W2120384002 cites W2070838832 @default.
• W2120384002 cites W2071108543 @default.
• W2120384002 cites W2071574279 @default.
• W2120384002 cites W2080057086 @default.
• W2120384002 cites W2086768206 @default.
• W2120384002 cites W2089170816 @default.
• W2120384002 cites W2093563294 @default.
• W2120384002 cites W2096136799 @default.
• W2120384002 cites W2103090698 @default.
• W2120384002 cites W2106882534 @default.
• W2120384002 cites W2114191153 @default.
• W2120384002 cites W2116699018 @default.
• W2120384002 cites W2118913904 @default.
• W2120384002 cites W2122162186 @default.
• W2120384002 cites W2123362038 @default.
• W2120384002 cites W2126351574 @default.
• W2120384002 cites W2128010249 @default.
• W2120384002 cites W2132632499 @default.
• W2120384002 cites W2133388516 @default.
• W2120384002 cites W2134642612 @default.
• W2120384002 cites W2142022928 @default.
• W2120384002 cites W2143163481 @default.
• W2120384002 cites W2144836517 @default.
• W2120384002 cites W2145074801 @default.
• W2120384002 cites W2146484207 @default.
• W2120384002 cites W2148750103 @default.
• W2120384002 cites W2154953845 @default.
• W2120384002 cites W2156958204 @default.
• W2120384002 cites W2159306398 @default.
• W2120384002 cites W2159959233 @default.
• W2120384002 cites W2160392063 @default.
• W2120384002 cites W2164719130 @default.
• W2120384002 cites W2165026014 @default.
• W2120384002 cites W2165514100 @default.
• W2120384002 cites W2167128386 @default.
• W2120384002 cites W2167675434 @default.
• W2120384002 cites W2601675613 @default.
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• W2120384002 doi "https://doi.org/10.1016/j.jaci.2014.10.020" @default.
• W2120384002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7173323" @default.
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• W2120384002 hasPublicationYear "2015" @default.
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