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• W2120386364 abstract "The aim of the study was to determine whether the bronchomotor effect of a deep inhalation (DI) may be detected during tidal breathing in asthmatic children with spontaneous airway obstruction (AO). Two groups of children aged 5–15 yrs were studied. AO was mild in group 1 (n=12, forced expiratory volume in one second (FEV₁) ≥75% predicted) and moderate-to-severe in group 2 (n=9, FEV₁ ≤70% pred). The forced oscillation technique at 12 Hz using a head generator allowed the determination of respiratory resistance in inspiration (<i>R</i>_rsi) and expiration (<i>R</i>_rse) before and after DI, at baseline and after salbutamol. At baseline, <i>R</i>_rsi but not <i>R</i>_rse was found to decrease significantly after DI in group 1 but not in group 2. The change induced by DI was significantly different in group 1 (−1.5±0.5 hPa·s·L⁻¹) compared to group 2 (0.5±0.5 hPa·s·L⁻¹) and exhibited significant negative correlation to FEV₁ % pred. After salbutamol, DI had no effect. In conclusion, asthmatic children show a bronchomotor response to deep inhalation that depends on the degree of airway obstruction. The effect is more readily demonstrated in inspiration than in expiration." @default.
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• W2120386364 date "2002-06-01" @default.
• W2120386364 modified "2023-10-15" @default.
• W2120386364 title "Respiratory impedance response to a deep inhalation in asthmatic children with spontaneous airway obstruction" @default.
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• W2120386364 doi "https://doi.org/10.1183/09031936.02.00992001" @default.
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