FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120396727> ?p ?o ?g. }

• W2120396727 endingPage "785" @default.
• W2120396727 startingPage "781" @default.
• W2120396727 abstract "Stavudine is a commonly used drug in paediatric antiretroviral treatment (ART) regimens. Due to toxicity concerns, however, the drug abacavir has replaced stavudine in first-line paediatric regimens in many countries. We describe the frequency of stavudine toxicity in children receiving ART at a treatment clinic in Soweto, South Africa.Data on patient characteristics and outcomes of ART were collected from a cohort of 2222 HIV-infected children initiating ART between 2004 and 2008 when stavudine-containing regimens were routinely recommended. At several time-points after treatment initiation, we estimate the proportion of children where an attending clinician discontinued stavudine due to lipodystrophy, pancreatitis, lactic acidosis or peripheral neuropathy. Factors associated with stavudine-related toxicities were identified.At ART initiation, most children had advanced disease. The majority initiated an efavirenz/lamivudine/stavudine regimen (n = 1422), and 76% of children remained on their initial ART regimen after a median 19.9 months of ART. Replacement of stavudine due to drug toxicity occurred at a rate of 28.8 per 1000 child years on treatment (95% confidence interval = 23.6-35.2). Rates of toxicity increased with treatment duration (in their first year of ART stavudine was replaced in 0.5% of children, but after 3 years stavudine had been changed to abacavir in 12.6% of children). Toxicity was more common in older children and in girls. Lipodystrophy accounted for 87 of 96 toxic events.Stavudine-associated toxicity resulting in single-drug substitution was uncommon in this cohort, though its frequency increased steadily with ART duration, especially with lipodystrophy. Where drug options are limited, stavudine remains a relatively well tolerated and effective option for children." @default.
• W2120396727 created "2016-06-24" @default.
• W2120396727 creator A5014104423 @default.
• W2120396727 creator A5065078265 @default.
• W2120396727 creator A5067097024 @default.
• W2120396727 creator A5069064367 @default.
• W2120396727 creator A5088651251 @default.
• W2120396727 creator A5090830881 @default.
• W2120396727 date "2013-03-13" @default.
• W2120396727 modified "2023-09-29" @default.
• W2120396727 title "Frequency of stavudine substitution due to toxicity in children receiving antiretroviral treatment in sub-Saharan Africa" @default.
• W2120396727 cites W1519158032 @default.
• W2120396727 cites W1970006957 @default.
• W2120396727 cites W1976022560 @default.
• W2120396727 cites W1998660799 @default.
• W2120396727 cites W2011037611 @default.
• W2120396727 cites W2021067597 @default.
• W2120396727 cites W2031650216 @default.
• W2120396727 cites W2043070094 @default.
• W2120396727 cites W2051972250 @default.
• W2120396727 cites W2056243308 @default.
• W2120396727 cites W2061496424 @default.
• W2120396727 cites W2083626453 @default.
• W2120396727 cites W2095400366 @default.
• W2120396727 cites W2107574856 @default.
• W2120396727 cites W2171494599 @default.
• W2120396727 cites W2487039045 @default.
• W2120396727 doi "https://doi.org/10.1097/qad.0b013e32835c54b8" @default.
• W2120396727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23169331" @default.
• W2120396727 hasPublicationYear "2013" @default.
• W2120396727 type Work @default.
• W2120396727 sameAs 2120396727 @default.
• W2120396727 citedByCount "20" @default.
• W2120396727 countsByYear W21203967272013 @default.
• W2120396727 countsByYear W21203967272014 @default.
• W2120396727 countsByYear W21203967272015 @default.
• W2120396727 countsByYear W21203967272016 @default.
• W2120396727 countsByYear W21203967272017 @default.
• W2120396727 countsByYear W21203967272018 @default.
• W2120396727 countsByYear W21203967272019 @default.
• W2120396727 countsByYear W21203967272020 @default.
• W2120396727 countsByYear W21203967272021 @default.
• W2120396727 crossrefType "journal-article" @default.
• W2120396727 hasAuthorship W2120396727A5014104423 @default.
• W2120396727 hasAuthorship W2120396727A5065078265 @default.
• W2120396727 hasAuthorship W2120396727A5067097024 @default.
• W2120396727 hasAuthorship W2120396727A5069064367 @default.
• W2120396727 hasAuthorship W2120396727A5088651251 @default.
• W2120396727 hasAuthorship W2120396727A5090830881 @default.
• W2120396727 hasBestOaLocation W21203967271 @default.
• W2120396727 hasConcept C126322002 @default.
• W2120396727 hasConcept C141071460 @default.
• W2120396727 hasConcept C142462285 @default.
• W2120396727 hasConcept C187212893 @default.
• W2120396727 hasConcept C203014093 @default.
• W2120396727 hasConcept C2522874641 @default.
• W2120396727 hasConcept C2777869810 @default.
• W2120396727 hasConcept C2779465607 @default.
• W2120396727 hasConcept C2779889181 @default.
• W2120396727 hasConcept C2780593183 @default.
• W2120396727 hasConcept C2780941825 @default.
• W2120396727 hasConcept C2781413609 @default.
• W2120396727 hasConcept C2993143319 @default.
• W2120396727 hasConcept C3013748606 @default.
• W2120396727 hasConcept C71924100 @default.
• W2120396727 hasConceptScore W2120396727C126322002 @default.
• W2120396727 hasConceptScore W2120396727C141071460 @default.
• W2120396727 hasConceptScore W2120396727C142462285 @default.
• W2120396727 hasConceptScore W2120396727C187212893 @default.
• W2120396727 hasConceptScore W2120396727C203014093 @default.
• W2120396727 hasConceptScore W2120396727C2522874641 @default.
• W2120396727 hasConceptScore W2120396727C2777869810 @default.
• W2120396727 hasConceptScore W2120396727C2779465607 @default.
• W2120396727 hasConceptScore W2120396727C2779889181 @default.
• W2120396727 hasConceptScore W2120396727C2780593183 @default.
• W2120396727 hasConceptScore W2120396727C2780941825 @default.
• W2120396727 hasConceptScore W2120396727C2781413609 @default.
• W2120396727 hasConceptScore W2120396727C2993143319 @default.
• W2120396727 hasConceptScore W2120396727C3013748606 @default.
• W2120396727 hasConceptScore W2120396727C71924100 @default.
• W2120396727 hasIssue "5" @default.
• W2120396727 hasLocation W21203967271 @default.
• W2120396727 hasLocation W21203967272 @default.
• W2120396727 hasOpenAccess W2120396727 @default.
• W2120396727 hasPrimaryLocation W21203967271 @default.
• W2120396727 hasRelatedWork W1508037561 @default.
• W2120396727 hasRelatedWork W1597235086 @default.
• W2120396727 hasRelatedWork W2119878887 @default.
• W2120396727 hasRelatedWork W2121641482 @default.
• W2120396727 hasRelatedWork W2150369519 @default.
• W2120396727 hasRelatedWork W2165003108 @default.
• W2120396727 hasRelatedWork W2320051647 @default.
• W2120396727 hasRelatedWork W2335165509 @default.
• W2120396727 hasRelatedWork W3185798809 @default.
• W2120396727 hasRelatedWork W4283588672 @default.
• W2120396727 hasVolume "27" @default.
• W2120396727 isParatext "false" @default.
• W2120396727 isRetracted "false" @default.

• next