FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120414457> ?p ?o ?g. }

• W2120414457 endingPage "1990" @default.
• W2120414457 startingPage "1988" @default.
• W2120414457 abstract "Liver cirrhosis (LC) is a chronic disease with high mortality rate. In the United States and Western world as well as Asian countries, LC is the major leading cause of death by disease. Yet, no effective therapeutic agent is available for LC treatment. Laboratory cirrhotic rats produced by dimethylnitrosamine administrations simulate the clinical features of human LC such as mortality, ascites, hepatic parenchymal cell destruction, and formation of connective tissue and nodular regeneration, providing a preclinical model to evaluate therapeutic efficacy of drugs and the underlying mechanisms. Oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] has been used clinically and is of little toxicity. Comprehensive mechanistic and phase IIa clinical studies supported the notion that oltipraz exerts chemopreventive effects against chemical carcinogenesis. We report here that oltipraz within the clinical dose range regenerates cirrhotic liver in the established LC rats as a result of reduction of the intensities of cirrhotic nodules, elimination of accumulated extracellular matrix, and inactivation of stellate cells, thereby improving survival rate. We also reveal that activation of CCAAT/enhancer binding protein by oltipraz inhibits transforming growth factor b1 gene expression in stellate cells, which provides a molecular target for pharmacological treatment of LC. Oltipraz is the first therapeutic agent that regenerates cirrhotic liver." @default.
• W2120414457 created "2016-06-24" @default.
• W2120414457 creator A5019233488 @default.
• W2120414457 creator A5032157494 @default.
• W2120414457 creator A5036364665 @default.
• W2120414457 creator A5049435041 @default.
• W2120414457 creator A5065001868 @default.
• W2120414457 creator A5083265432 @default.
• W2120414457 creator A5089461702 @default.
• W2120414457 date "2002-10-18" @default.
• W2120414457 modified "2023-10-16" @default.
• W2120414457 title "Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein‐mediated stellate cell inactivation" @default.
• W2120414457 cites W169315289 @default.
• W2120414457 cites W1975710755 @default.
• W2120414457 cites W1980089776 @default.
• W2120414457 cites W1981990833 @default.
• W2120414457 cites W1983541098 @default.
• W2120414457 cites W1988697362 @default.
• W2120414457 cites W2001398345 @default.
• W2120414457 cites W2003709460 @default.
• W2120414457 cites W2004317356 @default.
• W2120414457 cites W2009971610 @default.
• W2120414457 cites W2012349920 @default.
• W2120414457 cites W2012948713 @default.
• W2120414457 cites W2024289938 @default.
• W2120414457 cites W2025436511 @default.
• W2120414457 cites W2029634017 @default.
• W2120414457 cites W2031231091 @default.
• W2120414457 cites W2033772754 @default.
• W2120414457 cites W2042159165 @default.
• W2120414457 cites W2042172213 @default.
• W2120414457 cites W2042311776 @default.
• W2120414457 cites W2044052218 @default.
• W2120414457 cites W2044788719 @default.
• W2120414457 cites W2047841570 @default.
• W2120414457 cites W2048423904 @default.
• W2120414457 cites W2050067824 @default.
• W2120414457 cites W2050623951 @default.
• W2120414457 cites W2053882786 @default.
• W2120414457 cites W2055110491 @default.
• W2120414457 cites W2055994283 @default.
• W2120414457 cites W2063078020 @default.
• W2120414457 cites W2067829451 @default.
• W2120414457 cites W2070719198 @default.
• W2120414457 cites W2076101109 @default.
• W2120414457 cites W2076379317 @default.
• W2120414457 cites W2094932400 @default.
• W2120414457 cites W2123625253 @default.
• W2120414457 cites W2142546321 @default.
• W2120414457 cites W2147786790 @default.
• W2120414457 cites W2152404909 @default.
• W2120414457 cites W2155212724 @default.
• W2120414457 cites W2168720661 @default.
• W2120414457 cites W2181735016 @default.
• W2120414457 cites W2186542461 @default.
• W2120414457 cites W2187297575 @default.
• W2120414457 cites W2318448898 @default.
• W2120414457 cites W2323637528 @default.
• W2120414457 cites W2412505069 @default.
• W2120414457 doi "https://doi.org/10.1096/fj.02-0406fje" @default.
• W2120414457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12397085" @default.
• W2120414457 hasPublicationYear "2002" @default.
• W2120414457 type Work @default.
• W2120414457 sameAs 2120414457 @default.
• W2120414457 citedByCount "81" @default.
• W2120414457 countsByYear W21204144572012 @default.
• W2120414457 countsByYear W21204144572013 @default.
• W2120414457 countsByYear W21204144572014 @default.
• W2120414457 countsByYear W21204144572015 @default.
• W2120414457 countsByYear W21204144572016 @default.
• W2120414457 countsByYear W21204144572018 @default.
• W2120414457 countsByYear W21204144572019 @default.
• W2120414457 countsByYear W21204144572020 @default.
• W2120414457 countsByYear W21204144572021 @default.
• W2120414457 countsByYear W21204144572022 @default.
• W2120414457 countsByYear W21204144572023 @default.
• W2120414457 crossrefType "journal-article" @default.
• W2120414457 hasAuthorship W2120414457A5019233488 @default.
• W2120414457 hasAuthorship W2120414457A5032157494 @default.
• W2120414457 hasAuthorship W2120414457A5036364665 @default.
• W2120414457 hasAuthorship W2120414457A5049435041 @default.
• W2120414457 hasAuthorship W2120414457A5065001868 @default.
• W2120414457 hasAuthorship W2120414457A5083265432 @default.
• W2120414457 hasAuthorship W2120414457A5089461702 @default.
• W2120414457 hasConcept C126322002 @default.
• W2120414457 hasConcept C176891718 @default.
• W2120414457 hasConcept C2777075537 @default.
• W2120414457 hasConcept C2777214474 @default.
• W2120414457 hasConcept C2779102576 @default.
• W2120414457 hasConcept C2780496750 @default.
• W2120414457 hasConcept C29730261 @default.
• W2120414457 hasConcept C502942594 @default.
• W2120414457 hasConcept C71924100 @default.
• W2120414457 hasConceptScore W2120414457C126322002 @default.
• W2120414457 hasConceptScore W2120414457C176891718 @default.
• W2120414457 hasConceptScore W2120414457C2777075537 @default.
• W2120414457 hasConceptScore W2120414457C2777214474 @default.
• W2120414457 hasConceptScore W2120414457C2779102576 @default.

• next