Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120418787> ?p ?o ?g. }
- W2120418787 endingPage "392" @default.
- W2120418787 startingPage "375" @default.
- W2120418787 abstract "The L-type Ca(2+) current (I(Ca,L)) contributes to the generation and modulation of the pacemaker action potential (AP). We investigated facilitation of I(Ca,L) in sino-atrial cells.Facilitation was studied in regularly-beating cells isolated enzymatically from young albino rabbits (0.8-1 kg). We used the whole-cell patch-clamp technique to vary the frequency of the test depolarizations evoked at -10 mV or the conditioning diastolic membrane potential prior to the test pulse.High frequencies (range 0.2-3.5 Hz) slowed the decay kinetics of I(Ca,L) evoked from a holding potential (HP) of -80 mV in 68% of cells resulting in a larger Ca(2+) influx during the test pulse. The amount of facilitation increased progressively between 0.2 and 3.0 Hz. When the frequency was changed from 0.1 to 1 Hz, the averaged increase in the time integral of I(Ca,L) was 27+/-7% (n=22). Application of conditioning voltages between -80 and -50 mV induced similar facilitation of I(Ca,L) in 73% of cells. The maximal increase of Ca(2+) entry occurred between -60 and -50 mV, and was on average 38+/-14% for conditioning prepulses of 5 s in duration (n=15). Numerical simulations of the pacemaker activity showed that facilitation of I(Ca,L) promotes stability of sino-atrial rate by enhancing Ca(2+) entry, thus establishing a negative feedback control against excessive heart rate slowing.Facilitation of I(Ca,L) is present in rabbit sino-atrial cells. The underlying mechanism reflects modulation of I(Ca,L) decay kinetics by diastolic membrane potential and frequency of depolarization. This phenomenon may provide an important regulatory mechanism of sino-atrial automaticity." @default.
- W2120418787 created "2016-06-24" @default.
- W2120418787 creator A5002941063 @default.
- W2120418787 creator A5037127640 @default.
- W2120418787 creator A5041986611 @default.
- W2120418787 creator A5050244394 @default.
- W2120418787 creator A5051185691 @default.
- W2120418787 creator A5071108835 @default.
- W2120418787 creator A5072325518 @default.
- W2120418787 date "2000-12-01" @default.
- W2120418787 modified "2023-10-01" @default.
- W2120418787 title "Facilitation of the L-type calcium current in rabbit sino-atrial cells: effect on cardiac automaticity" @default.
- W2120418787 cites W1751701650 @default.
- W2120418787 cites W1897605829 @default.
- W2120418787 cites W1899877571 @default.
- W2120418787 cites W1966308708 @default.
- W2120418787 cites W1966921666 @default.
- W2120418787 cites W1968560076 @default.
- W2120418787 cites W1970312095 @default.
- W2120418787 cites W1975931806 @default.
- W2120418787 cites W1979705936 @default.
- W2120418787 cites W1981701151 @default.
- W2120418787 cites W1983128983 @default.
- W2120418787 cites W1984694963 @default.
- W2120418787 cites W1986158212 @default.
- W2120418787 cites W2001105552 @default.
- W2120418787 cites W2009667219 @default.
- W2120418787 cites W2012864815 @default.
- W2120418787 cites W2022417072 @default.
- W2120418787 cites W2030958371 @default.
- W2120418787 cites W2036874203 @default.
- W2120418787 cites W2038270377 @default.
- W2120418787 cites W2039620182 @default.
- W2120418787 cites W2042681520 @default.
- W2120418787 cites W2047077729 @default.
- W2120418787 cites W2055377397 @default.
- W2120418787 cites W2059364171 @default.
- W2120418787 cites W2077123850 @default.
- W2120418787 cites W2080530601 @default.
- W2120418787 cites W2087403500 @default.
- W2120418787 cites W2089903759 @default.
- W2120418787 cites W2092267745 @default.
- W2120418787 cites W2095196480 @default.
- W2120418787 cites W2101822309 @default.
- W2120418787 cites W2112810806 @default.
- W2120418787 cites W2114110583 @default.
- W2120418787 cites W2126308098 @default.
- W2120418787 cites W2129513982 @default.
- W2120418787 cites W2133933408 @default.
- W2120418787 cites W2134921936 @default.
- W2120418787 cites W2149349253 @default.
- W2120418787 cites W2160832669 @default.
- W2120418787 cites W2166779237 @default.
- W2120418787 cites W2173794755 @default.
- W2120418787 cites W2403714799 @default.
- W2120418787 cites W2418587257 @default.
- W2120418787 cites W2418749983 @default.
- W2120418787 cites W2430030570 @default.
- W2120418787 cites W2474141771 @default.
- W2120418787 cites W3026613709 @default.
- W2120418787 doi "https://doi.org/10.1016/s0008-6363(00)00182-6" @default.
- W2120418787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11090833" @default.
- W2120418787 hasPublicationYear "2000" @default.
- W2120418787 type Work @default.
- W2120418787 sameAs 2120418787 @default.
- W2120418787 citedByCount "32" @default.
- W2120418787 countsByYear W21204187872012 @default.
- W2120418787 countsByYear W21204187872013 @default.
- W2120418787 countsByYear W21204187872015 @default.
- W2120418787 countsByYear W21204187872017 @default.
- W2120418787 countsByYear W21204187872018 @default.
- W2120418787 countsByYear W21204187872019 @default.
- W2120418787 countsByYear W21204187872020 @default.
- W2120418787 countsByYear W21204187872021 @default.
- W2120418787 crossrefType "journal-article" @default.
- W2120418787 hasAuthorship W2120418787A5002941063 @default.
- W2120418787 hasAuthorship W2120418787A5037127640 @default.
- W2120418787 hasAuthorship W2120418787A5041986611 @default.
- W2120418787 hasAuthorship W2120418787A5050244394 @default.
- W2120418787 hasAuthorship W2120418787A5051185691 @default.
- W2120418787 hasAuthorship W2120418787A5071108835 @default.
- W2120418787 hasAuthorship W2120418787A5072325518 @default.
- W2120418787 hasBestOaLocation W21204187871 @default.
- W2120418787 hasConcept C105795698 @default.
- W2120418787 hasConcept C121332964 @default.
- W2120418787 hasConcept C12554922 @default.
- W2120418787 hasConcept C126322002 @default.
- W2120418787 hasConcept C1337776 @default.
- W2120418787 hasConcept C134018914 @default.
- W2120418787 hasConcept C164705383 @default.
- W2120418787 hasConcept C165801399 @default.
- W2120418787 hasConcept C169760540 @default.
- W2120418787 hasConcept C181911157 @default.
- W2120418787 hasConcept C185263204 @default.
- W2120418787 hasConcept C185592680 @default.
- W2120418787 hasConcept C2780167933 @default.
- W2120418787 hasConcept C33923547 @default.
- W2120418787 hasConcept C45262634 @default.