FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120426749> ?p ?o ?g. }

• W2120426749 endingPage "3926" @default.
• W2120426749 startingPage "3913" @default.
• W2120426749 abstract "miRNAs (miR) have been shown to modulate critical gene transcripts involved in tumorigenesis, but their role in tumor-mediated immunosuppression is largely unknown. On the basis of miRNA gene expression in gliomas using tissue microarrays, in situ hybridization, and molecular modeling, miR-124 was identified as a lead candidate for modulating STAT3 signaling, a key pathway mediating immunosuppression in the tumor microenvironment. miR-124 is absent in all grades and pathologic types of gliomas. Upon upregulating miR-124 in glioma cancer stem cells (gCSC), the STAT3 pathway was inhibited, and miR-124 reversed gCSC-mediated immunosuppression of T-cell proliferation and induction of forkhead box P3 (Foxp3)(+) regulatory T cells (Treg). Treatment of T cells from immunosuppressed glioblastoma patients with miR-124 induced marked effector response including upregulation of interleukin (IL)-2, IFN-γ, and TNF-α. Both systemic administration of miR-124 or adoptive miR-124-transfected T-cell transfers exerted potent anti-glioma therapeutic effects in clonotypic and genetically engineered murine models of glioblastoma and enhanced effector responses in the local tumor microenvironment. These therapeutic effects were ablated in both CD4(+)- and CD8(+)-depleted mice and nude mouse systems, indicating that the therapeutic effect of miR-124 depends on the presence of a T-cell-mediated antitumor immune response. Our findings highlight the potential application of miR-124 as a novel immunotherapeutic agent for neoplasms and serve as a model for identifying miRNAs that can be exploited as immunotherapeutics." @default.
• W2120426749 created "2016-06-24" @default.
• W2120426749 creator A5012403937 @default.
• W2120426749 creator A5013938672 @default.
• W2120426749 creator A5017578103 @default.
• W2120426749 creator A5022249471 @default.
• W2120426749 creator A5026241338 @default.
• W2120426749 creator A5040389541 @default.
• W2120426749 creator A5050191637 @default.
• W2120426749 creator A5055296314 @default.
• W2120426749 creator A5056347988 @default.
• W2120426749 creator A5062037505 @default.
• W2120426749 creator A5066544434 @default.
• W2120426749 creator A5076390925 @default.
• W2120426749 creator A5079081497 @default.
• W2120426749 creator A5083871900 @default.
• W2120426749 creator A5086529957 @default.
• W2120426749 creator A5086792863 @default.
• W2120426749 creator A5088821817 @default.
• W2120426749 date "2013-06-30" @default.
• W2120426749 modified "2023-10-17" @default.
• W2120426749 title "miR-124 Inhibits STAT3 Signaling to Enhance T Cell–Mediated Immune Clearance of Glioma" @default.
• W2120426749 cites W1498680542 @default.
• W2120426749 cites W1548640328 @default.
• W2120426749 cites W1570056825 @default.
• W2120426749 cites W1967946144 @default.
• W2120426749 cites W1970079141 @default.
• W2120426749 cites W1971820542 @default.
• W2120426749 cites W1978337436 @default.
• W2120426749 cites W1980500001 @default.
• W2120426749 cites W1987828713 @default.
• W2120426749 cites W1990079648 @default.
• W2120426749 cites W1993579134 @default.
• W2120426749 cites W2010180766 @default.
• W2120426749 cites W2010884432 @default.
• W2120426749 cites W2012430921 @default.
• W2120426749 cites W2026570544 @default.
• W2120426749 cites W2038874091 @default.
• W2120426749 cites W2039141906 @default.
• W2120426749 cites W2062165914 @default.
• W2120426749 cites W2062936534 @default.
• W2120426749 cites W2068910226 @default.
• W2120426749 cites W2078264780 @default.
• W2120426749 cites W2082102301 @default.
• W2120426749 cites W2097617161 @default.
• W2120426749 cites W2100453921 @default.
• W2120426749 cites W2104610341 @default.
• W2120426749 cites W2106537986 @default.
• W2120426749 cites W2110431989 @default.
• W2120426749 cites W2111635840 @default.
• W2120426749 cites W2111969156 @default.
• W2120426749 cites W2116641097 @default.
• W2120426749 cites W2120026864 @default.
• W2120426749 cites W2121010151 @default.
• W2120426749 cites W2123218517 @default.
• W2120426749 cites W2125521995 @default.
• W2120426749 cites W2127207254 @default.
• W2120426749 cites W2138702921 @default.
• W2120426749 cites W2138971681 @default.
• W2120426749 cites W2141048422 @default.
• W2120426749 cites W2148131374 @default.
• W2120426749 cites W2155164361 @default.
• W2120426749 cites W2156023352 @default.
• W2120426749 cites W2160828156 @default.
• W2120426749 cites W2163655902 @default.
• W2120426749 cites W2167715370 @default.
• W2120426749 cites W2168478794 @default.
• W2120426749 cites W2783142245 @default.
• W2120426749 doi "https://doi.org/10.1158/0008-5472.can-12-4318" @default.
• W2120426749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3780786" @default.
• W2120426749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23636127" @default.
• W2120426749 hasPublicationYear "2013" @default.
• W2120426749 type Work @default.
• W2120426749 sameAs 2120426749 @default.
• W2120426749 citedByCount "221" @default.
• W2120426749 countsByYear W21204267492013 @default.
• W2120426749 countsByYear W21204267492014 @default.
• W2120426749 countsByYear W21204267492015 @default.
• W2120426749 countsByYear W21204267492016 @default.
• W2120426749 countsByYear W21204267492017 @default.
• W2120426749 countsByYear W21204267492018 @default.
• W2120426749 countsByYear W21204267492019 @default.
• W2120426749 countsByYear W21204267492020 @default.
• W2120426749 countsByYear W21204267492021 @default.
• W2120426749 countsByYear W21204267492022 @default.
• W2120426749 countsByYear W21204267492023 @default.
• W2120426749 crossrefType "journal-article" @default.
• W2120426749 hasAuthorship W2120426749A5012403937 @default.
• W2120426749 hasAuthorship W2120426749A5013938672 @default.
• W2120426749 hasAuthorship W2120426749A5017578103 @default.
• W2120426749 hasAuthorship W2120426749A5022249471 @default.
• W2120426749 hasAuthorship W2120426749A5026241338 @default.
• W2120426749 hasAuthorship W2120426749A5040389541 @default.
• W2120426749 hasAuthorship W2120426749A5050191637 @default.
• W2120426749 hasAuthorship W2120426749A5055296314 @default.
• W2120426749 hasAuthorship W2120426749A5056347988 @default.
• W2120426749 hasAuthorship W2120426749A5062037505 @default.
• W2120426749 hasAuthorship W2120426749A5066544434 @default.

• next