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• W2120430542 abstract "67 Infants with pathological 24-hour pH-monitoring(pH) results may exhibit a cyclic increase in the amount and duration of oesophageal acid exposure toward the ends of interfeeding periods, associated with the gradual decrease of the baseline. Such cyclic interfeeding drifts (CID) were encountered also in the oesophagus tracings of several regurgitating infants with “normal” pH results. We prospectively studied whether CIDs may be also indicative of significant non-acid or mixed GOR. METHODS: Formula fed infants aged <1 year with predominantly regurgitation type complaints with either elevated relative reflux index (RI) >5% (Group I, n=35) or with normal pH results, but having at least 3 CIDs/day (Group II, n=21) were enrolled for prospective cisapride treatment and follow up 2 channels oesophageal / gastric pH-metry at the age of 2-3 years (in drugfree interval). 30/35 pts in Group I. also had >3 CIDs/day pattern. 4 pts from Group I. and one patient from Group II. underwent Nissen fundoplication because of severe respiratory symptoms, and were excluded from further numerical analysis. RESULTS: Except the pts treated surgically, all pts improved on prokinetic therapy. TableNone of the parameters showed significant differences between Group I. and II. pts at the age of 2-3 years. Differences in the oesophageal area >pH4 between first postpandial and last praeprandial hours (p<0.001) were characteristic for tracings with CIDs in contrast to pathological pH registrates in older ages. 8/31 pts of Group I. and 15/20 pts of Group II. received hypoallergenic feeding at the time of first pH. Hypoallergenic formula fed pts (n=23) had lower RI, reflux numbers and <pH4 area (all p<0.001) compared to those with cow's milk based feeding. CONCLUSIONS: The described,,dentate” oesophageal pattern was highly predictive for GOR disease lasting beyond infancy, even in pts with initially low oesophageal acid exposure. Differences in the hourly distribution of area type parameters, such as area>pH4 seem promising to characterize this pattern. Hypoallergenic formulas may influence the sensitivity of pH-metry, but may have additional benefit for the treatment as well, independent of food allergy." @default.
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• W2120430542 date "1998-05-01" @default.
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• W2120430542 title "ARE INFANTS WITH REGURGITATION AND NEGATIVE pH-METRY AT RISK FOR LONG-TERM GOR DISEASE?" @default.
• W2120430542 doi "https://doi.org/10.1097/00005176-199805000-00076" @default.
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