FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120432324> ?p ?o ?g. }

• W2120432324 abstract "Background: Compared with common well-differentiated thyroid carcinomas, the genetic alterations underlying the development and progression of anaplastic thyroid carcinomas (ATC) are still uncharacterized. Comparative genomic hybridization (CGH) is a cytogenetic technique that can identify gains and losses in the DNA sequence copy number in tumors. Methods: The authors studied the changes in the DNA copy number due to CGH in paraffin-embedded tissue blocks of 17 ATC cases, and tried to ascertain whether the genomic changes correlate with the clinicopathological parameters including patients' age, sex, primary tumor size, lymphovascular invasion, extrathyroid extension, regional node metastasis and immunohistochemical expression of cyclin D1. Results: Fourteen of the 17 samples (82.4%) showed chromosomal changes, with a mean number of gains or losses per carcinoma of 3.6 (range 2~6; 30 gains and 21 losses). The most frequently detected imbalance was the gain of chromosome 1q, which was seen in 35.7% of cases, particularly commonly in ATC associated with a papillary thyroid carcinoma. Other commonly occurring gains were present in 11q13 and 19 (28.6%, respectively). Genomic amplification was detected in all four cases showing the 11q13 gain. Genomic losses were commonly noted in 3q, 6q, 18q and×(21.4%, respectively). When numerical CGH alterations were compared to the clinicopathological parameters, there were no significant correlations (P > 0.05). Cyclin D1 expression was noted in sixteen of the 17 cases (94.1%), but the extent of cyclin D1 expression was not correlated with the numerical CGH alterations (P > 0.05). Conclusion: Taken together, the aberrations of 1q, 3q, 6q, 11q13 and 18q are relatively common in ATC, and may play an important role it developement. These findings should lead to the characterization of tumor suppressor genes and oncogenes that are potentially involved in the carcinogenesis of ATC. The amplification of 11q13 is characteristically found, but cyclin D1 in this region may be innocent of the aggressiveness of these carcinomas (J Kor Soc Endocrinol 20:362～374, 2005)." @default.
• W2120432324 created "2016-06-24" @default.
• W2120432324 creator A5052575283 @default.
• W2120432324 creator A5059188866 @default.
• W2120432324 creator A5074104769 @default.
• W2120432324 creator A5079992055 @default.
• W2120432324 creator A5087132038 @default.
• W2120432324 date "2005-01-01" @default.
• W2120432324 modified "2023-09-27" @default.
• W2120432324 title "Chromosomal Analysis of Anaplastic Thyroid Carcinomas by Comparative Genomic Hybridization" @default.
• W2120432324 cites W1496877189 @default.
• W2120432324 cites W1544851750 @default.
• W2120432324 cites W1553432789 @default.
• W2120432324 cites W1964657899 @default.
• W2120432324 cites W1967442639 @default.
• W2120432324 cites W1968046362 @default.
• W2120432324 cites W1974031179 @default.
• W2120432324 cites W1993770335 @default.
• W2120432324 cites W2001258296 @default.
• W2120432324 cites W2001434344 @default.
• W2120432324 cites W2002346157 @default.
• W2120432324 cites W2002942077 @default.
• W2120432324 cites W2005646146 @default.
• W2120432324 cites W2008956564 @default.
• W2120432324 cites W2033345513 @default.
• W2120432324 cites W2034269086 @default.
• W2120432324 cites W2040127250 @default.
• W2120432324 cites W2042793483 @default.
• W2120432324 cites W2060386875 @default.
• W2120432324 cites W2060703328 @default.
• W2120432324 cites W2072274025 @default.
• W2120432324 cites W2077190208 @default.
• W2120432324 cites W2077192917 @default.
• W2120432324 cites W2080249704 @default.
• W2120432324 cites W2085575175 @default.
• W2120432324 cites W2092990212 @default.
• W2120432324 cites W2122083106 @default.
• W2120432324 cites W2128495860 @default.
• W2120432324 cites W2132835508 @default.
• W2120432324 cites W2144634347 @default.
• W2120432324 cites W2150171655 @default.
• W2120432324 cites W2170893575 @default.
• W2120432324 cites W2320705026 @default.
• W2120432324 cites W2342878392 @default.
• W2120432324 cites W2391575159 @default.
• W2120432324 cites W2403512283 @default.
• W2120432324 cites W2104698438 @default.
• W2120432324 doi "https://doi.org/10.3803/jkes.2005.20.4.362" @default.
• W2120432324 hasPublicationYear "2005" @default.
• W2120432324 type Work @default.
• W2120432324 sameAs 2120432324 @default.
• W2120432324 citedByCount "0" @default.
• W2120432324 crossrefType "journal-article" @default.
• W2120432324 hasAuthorship W2120432324A5052575283 @default.
• W2120432324 hasAuthorship W2120432324A5059188866 @default.
• W2120432324 hasAuthorship W2120432324A5074104769 @default.
• W2120432324 hasAuthorship W2120432324A5079992055 @default.
• W2120432324 hasAuthorship W2120432324A5087132038 @default.
• W2120432324 hasConcept C104317684 @default.
• W2120432324 hasConcept C120821319 @default.
• W2120432324 hasConcept C121608353 @default.
• W2120432324 hasConcept C124942203 @default.
• W2120432324 hasConcept C141231307 @default.
• W2120432324 hasConcept C142724271 @default.
• W2120432324 hasConcept C199835354 @default.
• W2120432324 hasConcept C204232928 @default.
• W2120432324 hasConcept C2778740770 @default.
• W2120432324 hasConcept C2779013556 @default.
• W2120432324 hasConcept C29537977 @default.
• W2120432324 hasConcept C2993294228 @default.
• W2120432324 hasConcept C30481170 @default.
• W2120432324 hasConcept C502942594 @default.
• W2120432324 hasConcept C526584372 @default.
• W2120432324 hasConcept C54355233 @default.
• W2120432324 hasConcept C71924100 @default.
• W2120432324 hasConcept C86803240 @default.
• W2120432324 hasConceptScore W2120432324C104317684 @default.
• W2120432324 hasConceptScore W2120432324C120821319 @default.
• W2120432324 hasConceptScore W2120432324C121608353 @default.
• W2120432324 hasConceptScore W2120432324C124942203 @default.
• W2120432324 hasConceptScore W2120432324C141231307 @default.
• W2120432324 hasConceptScore W2120432324C142724271 @default.
• W2120432324 hasConceptScore W2120432324C199835354 @default.
• W2120432324 hasConceptScore W2120432324C204232928 @default.
• W2120432324 hasConceptScore W2120432324C2778740770 @default.
• W2120432324 hasConceptScore W2120432324C2779013556 @default.
• W2120432324 hasConceptScore W2120432324C29537977 @default.
• W2120432324 hasConceptScore W2120432324C2993294228 @default.
• W2120432324 hasConceptScore W2120432324C30481170 @default.
• W2120432324 hasConceptScore W2120432324C502942594 @default.
• W2120432324 hasConceptScore W2120432324C526584372 @default.
• W2120432324 hasConceptScore W2120432324C54355233 @default.
• W2120432324 hasConceptScore W2120432324C71924100 @default.
• W2120432324 hasConceptScore W2120432324C86803240 @default.
• W2120432324 hasLocation W21204323241 @default.
• W2120432324 hasOpenAccess W2120432324 @default.
• W2120432324 hasPrimaryLocation W21204323241 @default.
• W2120432324 hasRelatedWork W1977479086 @default.
• W2120432324 hasRelatedWork W2139772786 @default.
• W2120432324 hasRelatedWork W2413504851 @default.

• next