FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120445941> ?p ?o ?g. }

• W2120445941 endingPage "8144" @default.
• W2120445941 startingPage "8134" @default.
• W2120445941 abstract "Carbonated drinks elicit a sensation that is highly sought after, yet the underlying neural mechanisms are ill-defined. We hypothesize that CO₂ is converted via carbonic anhydrase into carbonic acid, which excites lingual nociceptors that project to the trigeminal nuclei. We investigated this hypothesis using three methodological approaches. Electrophysiological methods were used to record responses of single units located in superficial laminae of the dorsomedial aspect of trigeminal subnucleus caudalis (Vc) evoked by lingual application of carbonated water in anesthetized rats. After pretreatment of the tongue with the carbonic anhydrase inhibitor dorzolamide, neuronal responses to carbonated water were significantly attenuated, followed by recovery. Using c-Fos immunohistochemistry, we investigated the distribution of brainstem neurons activated by intraoral carbonated water. Fos-like immunoreactivity (FLI) was significantly higher in the superficial laminae of dorsomedial and ventrolateral Vc in animals treated with carbonated water versus controls. Dorzolamide pretreatment significantly reduced FLI in dorsomedial Vc. We also examined the sensation elicited by carbonated water in human psychophysical studies. When one side of the tongue was pretreated with dorzolamide, followed by bilateral application of carbonated water, a significant majority of subjects chose the untreated side as having a stronger sensation and assigned significantly higher intensity ratings to that side. Dorzolamide did not reduce irritation elicited by pentanoic acid. The present data support the hypothesis that carbonated water excites lingual nociceptors via a carbonic anhydrase-dependent process, in turn exciting neurons in Vc that are presumably involved in signaling oral irritant sensations." @default.
• W2120445941 created "2016-06-24" @default.
• W2120445941 creator A5003855915 @default.
• W2120445941 creator A5026591015 @default.
• W2120445941 creator A5036559669 @default.
• W2120445941 creator A5059958654 @default.
• W2120445941 creator A5090020371 @default.
• W2120445941 date "1999-09-15" @default.
• W2120445941 modified "2023-10-03" @default.
• W2120445941 title "Neurobiological and Psychophysical Mechanisms Underlying the Oral Sensation Produced by Carbonated Water" @default.
• W2120445941 cites W1484418190 @default.
• W2120445941 cites W1586150986 @default.
• W2120445941 cites W1635224753 @default.
• W2120445941 cites W1832611062 @default.
• W2120445941 cites W1832891917 @default.
• W2120445941 cites W1904278077 @default.
• W2120445941 cites W1928547908 @default.
• W2120445941 cites W1963729589 @default.
• W2120445941 cites W1964838839 @default.
• W2120445941 cites W1972508830 @default.
• W2120445941 cites W1974350225 @default.
• W2120445941 cites W1974642350 @default.
• W2120445941 cites W1981572679 @default.
• W2120445941 cites W1985452543 @default.
• W2120445941 cites W1986237784 @default.
• W2120445941 cites W1989720563 @default.
• W2120445941 cites W1991250156 @default.
• W2120445941 cites W1995461894 @default.
• W2120445941 cites W1995953402 @default.
• W2120445941 cites W1996723516 @default.
• W2120445941 cites W1998198806 @default.
• W2120445941 cites W2001440568 @default.
• W2120445941 cites W2004632779 @default.
• W2120445941 cites W2005055877 @default.
• W2120445941 cites W2008617116 @default.
• W2120445941 cites W2009199141 @default.
• W2120445941 cites W2009793474 @default.
• W2120445941 cites W2013539122 @default.
• W2120445941 cites W2014011673 @default.
• W2120445941 cites W2019761094 @default.
• W2120445941 cites W2021821583 @default.
• W2120445941 cites W2024006200 @default.
• W2120445941 cites W2027189531 @default.
• W2120445941 cites W2027456994 @default.
• W2120445941 cites W2041254023 @default.
• W2120445941 cites W2047127174 @default.
• W2120445941 cites W2064057501 @default.
• W2120445941 cites W2065778506 @default.
• W2120445941 cites W2072208143 @default.
• W2120445941 cites W2074457024 @default.
• W2120445941 cites W2075921161 @default.
• W2120445941 cites W2080554635 @default.
• W2120445941 cites W2083433123 @default.
• W2120445941 cites W2084628473 @default.
• W2120445941 cites W2086851754 @default.
• W2120445941 cites W2089860280 @default.
• W2120445941 cites W2089939662 @default.
• W2120445941 cites W2090420678 @default.
• W2120445941 cites W2095325289 @default.
• W2120445941 cites W2101625451 @default.
• W2120445941 cites W2103490623 @default.
• W2120445941 cites W2119336577 @default.
• W2120445941 cites W2124660317 @default.
• W2120445941 cites W2144695528 @default.
• W2120445941 cites W2145856781 @default.
• W2120445941 cites W2147905820 @default.
• W2120445941 cites W2170291000 @default.
• W2120445941 cites W2218868889 @default.
• W2120445941 cites W2221889561 @default.
• W2120445941 cites W2249630655 @default.
• W2120445941 cites W2253371316 @default.
• W2120445941 cites W2282628030 @default.
• W2120445941 cites W2294293049 @default.
• W2120445941 cites W2337614773 @default.
• W2120445941 cites W2346891312 @default.
• W2120445941 cites W2400425963 @default.
• W2120445941 cites W2417092171 @default.
• W2120445941 cites W2425650887 @default.
• W2120445941 cites W2433657415 @default.
• W2120445941 doi "https://doi.org/10.1523/jneurosci.19-18-08134.1999" @default.
• W2120445941 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782458" @default.
• W2120445941 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10479713" @default.
• W2120445941 hasPublicationYear "1999" @default.
• W2120445941 type Work @default.
• W2120445941 sameAs 2120445941 @default.
• W2120445941 citedByCount "71" @default.
• W2120445941 countsByYear W21204459412012 @default.
• W2120445941 countsByYear W21204459412013 @default.
• W2120445941 countsByYear W21204459412014 @default.
• W2120445941 countsByYear W21204459412015 @default.
• W2120445941 countsByYear W21204459412016 @default.
• W2120445941 countsByYear W21204459412017 @default.
• W2120445941 countsByYear W21204459412018 @default.
• W2120445941 countsByYear W21204459412019 @default.
• W2120445941 countsByYear W21204459412020 @default.
• W2120445941 countsByYear W21204459412021 @default.
• W2120445941 countsByYear W21204459412022 @default.
• W2120445941 countsByYear W21204459412023 @default.

• next