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• W2120451331 endingPage "1814" @default.
• W2120451331 startingPage "1809" @default.
• W2120451331 abstract "The cardiac steroid ouabain, a known inhibitor of the sodium pump (Na+, K+ -ATPase), has been shown to release endothelin from endothelial cells when used at concentrations below those that inhibit the pump. The present study addresses the question of which signaling pathways are activated by ouabain in endothelial cells. Our findings indicate that ouabain, applied at low concentrations to human umbilical cord endothelial cells (HUAECs), induces a reaction cascade that leads to translocation of endothelial nitric oxide synthase (eNOS) and to activation of phosphatidylinositol 3-kinase (PI3K). These events are followed by phosphorylation of Akt (also known as protein kinase B, or PKB) and activation of eNOS by phosphorylation. This signaling pathway, which results in increased nitric oxide (NO) production in HUAECs, is inhibited by the PI3K-specific inhibitor LY294002. Activation of the reaction cascade is not due to endothelin-1 (ET-1) binding to the ET-1 receptor B (ETB), since application of the ETB-specific antagonist BQ-788 did not have any effect on Akt or eNOS phosphorylation. The results shown here indicate that ouabain binding to the sodium pump results in the activation of the proliferation and survival pathways involving PI3K, Akt activation, stimulation of eNOS, and production of NO in HUAECs. Together with results from previous publications, the current investigation implies that the sodium pump is involved in vascular tone regulation." @default.
• W2120451331 created "2016-06-24" @default.
• W2120451331 creator A5046461387 @default.
• W2120451331 creator A5071152965 @default.
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• W2120451331 date "2006-11-01" @default.
• W2120451331 modified "2023-09-26" @default.
• W2120451331 title "Signaling pathways involving the sodium pump stimulate NO production in endothelial cells" @default.
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• W2120451331 doi "https://doi.org/10.1016/j.bbamem.2006.09.006" @default.
• W2120451331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17054900" @default.
• W2120451331 hasPublicationYear "2006" @default.
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