FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120478165> ?p ?o ?g. }

• W2120478165 endingPage "1450" @default.
• W2120478165 startingPage "1445" @default.
• W2120478165 abstract "Tachykinins, such as substance P, might be involved in the development of airway hyperresponsiveness (AHR) and airway inflammation. However, it is unknown which tachykinin receptors mediate these biological activities. The effects of two antagonists of tachykinin neurokinin-1 (NK1) and tachykinin neurokinin-2 (NK2) receptors, SR 140333 and SR 48968, respectively, were investigated on substance P (SP)-induced airway hyperresponsiveness and potentiation of the histamine-induced increase in microvascular leakage, in phosphoramidon-pretreated guinea-pigs. Guinea-pigs were pretreated with phosphoramidon (0.1 mM aerosol for 15 min) and exposed 15 min later to saline solution alone or to saline solution containing SP (0.1 mg.mL-1 for 30 min). Twenty four hours later, the animals were anaesthetized and prepared for the recording of the pulmonary inflation pressure (PIP) to acetylcholine or for the investigation of microvascular leakage to histamine. Pretreatment of the guinea-pigs with a single dose of SR 48968 (1 mg.kg-1, i.p.) 30 min before SP exposure, significantly prevented the development of AHR, whereas SR 140333 (1 mg.kg-1, i.p.) did not. In a second set of experiments, phosphoramidon-pretreated guinea-pigs exposed to SP presented a significant potentiation of the histamine-induced increase in microvascular leakage in pulmonary airways. When the guinea-pigs were pretreated with SR 140333, an inhibition of the increased microvascular leakage to histamine was observed. In contrast, no significant inhibitory activity was noted when the guinea-pigs were pretreated with SR 48968. The present data demonstrate the importance of tachykinin NK2 receptor stimulation in the development of airway hyperresponsiveness and that of tachykinin NK1 receptor stimulation in microvascular leakage hypersensitivity in phosphoramidon-pretreated and substance P-exposed guinea-pigs. The results also suggest a dissociation between the presence of microvascular leakage and the occurrence of airway hyperresponsiveness." @default.
• W2120478165 created "2016-06-24" @default.
• W2120478165 creator A5021559359 @default.
• W2120478165 creator A5059075698 @default.
• W2120478165 creator A5067017996 @default.
• W2120478165 creator A5069946536 @default.
• W2120478165 creator A5072778963 @default.
• W2120478165 creator A5079640130 @default.
• W2120478165 date "1996-06-01" @default.
• W2120478165 modified "2023-10-17" @default.
• W2120478165 title "Involvement of tachykinin NK<SUB>1</SUB> and NK<SUB>2</SUB> receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs" @default.
• W2120478165 cites W1512291126 @default.
• W2120478165 cites W1964647063 @default.
• W2120478165 cites W1973850387 @default.
• W2120478165 cites W1976928300 @default.
• W2120478165 cites W1980203034 @default.
• W2120478165 cites W1981748560 @default.
• W2120478165 cites W1990673708 @default.
• W2120478165 cites W1995688653 @default.
• W2120478165 cites W2004634344 @default.
• W2120478165 cites W2006920347 @default.
• W2120478165 cites W2014001342 @default.
• W2120478165 cites W2023573955 @default.
• W2120478165 cites W2025388665 @default.
• W2120478165 cites W2027810909 @default.
• W2120478165 cites W2028820557 @default.
• W2120478165 cites W2048590537 @default.
• W2120478165 cites W2052492580 @default.
• W2120478165 cites W2056148543 @default.
• W2120478165 cites W2057254515 @default.
• W2120478165 cites W2059443607 @default.
• W2120478165 cites W2073557461 @default.
• W2120478165 cites W2073574983 @default.
• W2120478165 cites W2080761218 @default.
• W2120478165 cites W2089546084 @default.
• W2120478165 cites W2091303128 @default.
• W2120478165 cites W2094452203 @default.
• W2120478165 cites W2106423953 @default.
• W2120478165 cites W2130269666 @default.
• W2120478165 cites W2148484236 @default.
• W2120478165 cites W2285130756 @default.
• W2120478165 cites W2304963522 @default.
• W2120478165 cites W240943799 @default.
• W2120478165 doi "https://doi.org/10.1183/09031936.96.09071445" @default.
• W2120478165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8836657" @default.
• W2120478165 hasPublicationYear "1996" @default.
• W2120478165 type Work @default.
• W2120478165 sameAs 2120478165 @default.
• W2120478165 citedByCount "25" @default.
• W2120478165 countsByYear W21204781652013 @default.
• W2120478165 countsByYear W21204781652015 @default.
• W2120478165 countsByYear W21204781652021 @default.
• W2120478165 crossrefType "journal-article" @default.
• W2120478165 hasAuthorship W2120478165A5021559359 @default.
• W2120478165 hasAuthorship W2120478165A5059075698 @default.
• W2120478165 hasAuthorship W2120478165A5067017996 @default.
• W2120478165 hasAuthorship W2120478165A5069946536 @default.
• W2120478165 hasAuthorship W2120478165A5072778963 @default.
• W2120478165 hasAuthorship W2120478165A5079640130 @default.
• W2120478165 hasBestOaLocation W21204781651 @default.
• W2120478165 hasConcept C1122143 @default.
• W2120478165 hasConcept C118303440 @default.
• W2120478165 hasConcept C126322002 @default.
• W2120478165 hasConcept C134018914 @default.
• W2120478165 hasConcept C144980905 @default.
• W2120478165 hasConcept C170493617 @default.
• W2120478165 hasConcept C185592680 @default.
• W2120478165 hasConcept C2776042228 @default.
• W2120478165 hasConcept C2776089194 @default.
• W2120478165 hasConcept C2776533618 @default.
• W2120478165 hasConcept C2777056410 @default.
• W2120478165 hasConcept C2778815084 @default.
• W2120478165 hasConcept C2780268870 @default.
• W2120478165 hasConcept C2780769369 @default.
• W2120478165 hasConcept C2781359426 @default.
• W2120478165 hasConcept C55938493 @default.
• W2120478165 hasConcept C71924100 @default.
• W2120478165 hasConcept C98274493 @default.
• W2120478165 hasConceptScore W2120478165C1122143 @default.
• W2120478165 hasConceptScore W2120478165C118303440 @default.
• W2120478165 hasConceptScore W2120478165C126322002 @default.
• W2120478165 hasConceptScore W2120478165C134018914 @default.
• W2120478165 hasConceptScore W2120478165C144980905 @default.
• W2120478165 hasConceptScore W2120478165C170493617 @default.
• W2120478165 hasConceptScore W2120478165C185592680 @default.
• W2120478165 hasConceptScore W2120478165C2776042228 @default.
• W2120478165 hasConceptScore W2120478165C2776089194 @default.
• W2120478165 hasConceptScore W2120478165C2776533618 @default.
• W2120478165 hasConceptScore W2120478165C2777056410 @default.
• W2120478165 hasConceptScore W2120478165C2778815084 @default.
• W2120478165 hasConceptScore W2120478165C2780268870 @default.
• W2120478165 hasConceptScore W2120478165C2780769369 @default.
• W2120478165 hasConceptScore W2120478165C2781359426 @default.
• W2120478165 hasConceptScore W2120478165C55938493 @default.
• W2120478165 hasConceptScore W2120478165C71924100 @default.
• W2120478165 hasConceptScore W2120478165C98274493 @default.
• W2120478165 hasIssue "7" @default.
• W2120478165 hasLocation W21204781651 @default.

• next