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- W2120485135 abstract "While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of Neuron. While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye. Here, we propose that new granule cells in the OB and DG may function as modulators of principal neurons to influence pattern separation and that adult neurogenesis constitutes an adaptive mechanism to optimally encode contextual or olfactory information. See the related Perspective from Aimone, Deng, and Gage, “Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation,” in this issue of Neuron. Here, we present two paired Perspectives that explore alternative viewpoints on the roles of adult-born neurons. In these Point/Counterpoint pieces, René Hen and colleagues and Rusty Gage and colleagues present their views on the potential functions of adult neurogenesis and how new neurons contribute to cognition and behavior. We hope that these paired Perspectives will be informative and will stimulate discussion in the field. Here, we present two paired Perspectives that explore alternative viewpoints on the roles of adult-born neurons. In these Point/Counterpoint pieces, René Hen and colleagues and Rusty Gage and colleagues present their views on the potential functions of adult neurogenesis and how new neurons contribute to cognition and behavior. We hope that these paired Perspectives will be informative and will stimulate discussion in the field." @default.
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- W2120485135 date "2011-05-01" @default.
- W2120485135 modified "2023-10-15" @default.
- W2120485135 title "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb" @default.
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- W2120485135 doi "https://doi.org/10.1016/j.neuron.2011.05.012" @default.
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