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• W2120492376 abstract "Phosphorylation of conserved Y1S2P3T4S5P6S7 repeats in the C-terminal domain of largest subunit of RNA polymerase II (RNAPII CTD) plays a central role in the regulation of transcription and cotranscriptional RNA processing. Here, we show that Ser phosphorylation of Arabidopsis thaliana RNAPII CTD is governed by CYCLIN-DEPENDENT KINASE F;1 (CDKF;1), a unique plant-specific CTD S7-kinase. CDKF;1 is required for in vivo activation of functionally redundant CYCLIN-DEPENDENT KINASE Ds (CDKDs), which are major CTD S5-kinases that also phosphorylate in vitro the S2 and S7 CTD residues. Inactivation of CDKF;1 causes extreme dwarfism and sterility. Inhibition of CTD S7-phosphorylation in germinating cdkf;1 seedlings is accompanied by 3′-polyadenylation defects of pre-microRNAs and transcripts encoding key regulators of small RNA biogenesis pathways. The cdkf;1 mutation also decreases the levels of both precursor and mature small RNAs without causing global downregulation of the protein-coding transcriptome and enhances the removal of introns that carry pre-microRNA stem-loops. A triple cdkd knockout mutant is not viable, but a combination of null and weak cdkd;3 alleles in a triple cdkd123* mutant permits semidwarf growth. Germinating cdkd123* seedlings show reduced CTD S5-phosphorylation, accumulation of uncapped precursor microRNAs, and a parallel decrease in mature microRNA. During later development of cdkd123* seedlings, however, S7-phosphorylation and unprocessed small RNA levels decline similarly as in the cdkf;1 mutant. Taken together, cotranscriptional processing and stability of a set of small RNAs and transcripts involved in their biogenesis are sensitive to changes in the phosphorylation of RNAPII CTD by CDKF;1 and CDKDs." @default.
• W2120492376 created "2016-06-24" @default.
• W2120492376 creator A5026495230 @default.
• W2120492376 creator A5035228555 @default.
• W2120492376 creator A5041391484 @default.
• W2120492376 creator A5064886500 @default.
• W2120492376 creator A5083273363 @default.
• W2120492376 date "2012-04-01" @default.
• W2120492376 modified "2023-09-30" @default.
• W2120492376 title "CDKF;1 and CDKD Protein Kinases Regulate Phosphorylation of Serine Residues in the C-Terminal Domain of <i>Arabidopsis</i> RNA Polymerase II" @default.
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• W2120492376 doi "https://doi.org/10.1105/tpc.112.096834" @default.
• W2120492376 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398568" @default.
• W2120492376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22547781" @default.
• W2120492376 hasPublicationYear "2012" @default.
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