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• W2120495508 startingPage "1672" @default.
• W2120495508 abstract "It has been demonstrated that human immunodeficiency virus type 1 (HIV-1) replication persists in most infected individuals receiving highly active antiretroviral therapy (HAART). However, studies addressing the relationship between low levels of ongoing viral replication and immunologic parameters, such as the CD4+:CD8+ T cell ratio, in such individuals have been lacking. Here, a statistically significant inverse correlation is shown between the frequency of CD4+ T cells carrying HIV-1 proviral DNA and the CD4+:CD8+ T cell ratio in infected individuals receiving HAART and in whom plasma viremia had been suppressed below the limit of detection for prolonged periods of time. No correlation was found between the frequency of HIV-1-specific cytotoxic CD8+ T lymphocytes (CTLs) and the CD4+ :CD8+ T cell ratios in those individuals. These data suggest that persistent, low-level, ongoing viral replication, although not sufficient to maintain HIV-1- specific CTL responses, may explain, in part, why normalization of the CD4+ :CD8+ T cell ratio is not achieved in some infected individuals successfully treated with HAART." @default.
• W2120495508 created "2016-06-24" @default.
• W2120495508 creator A5013463034 @default.
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• W2120495508 date "2002-06-01" @default.
• W2120495508 modified "2023-09-25" @default.
• W2120495508 title "Relationship between the Size of the Human Immunodeficiency Virus Type 1 (HIV‐1) Reservoir in Peripheral Blood CD4⁺T Cells and CD4⁺:CD8⁺T Cell Ratios in Aviremic HIV‐1–Infected Individuals Receiving Long‐Term Highly Active Antiretroviral Therapy" @default.
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• W2120495508 doi "https://doi.org/10.1086/340521" @default.
• W2120495508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12023777" @default.
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