FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120502238> ?p ?o ?g. }

• W2120502238 endingPage "237" @default.
• W2120502238 startingPage "233" @default.
• W2120502238 abstract "Problem Uterine innate immunity remains poorly characterized, and while endometrial endothelial cells are known to express Toll‐like receptors ( TLR s), little is known about their function in these cells. The present study evaluated the effect of Gram‐negative bacterial lipopolysaccharide ( LPS ) on human endometrial endothelial cell ( HEEC s) cytokine secretion and tissue factor expression, and the role of TLR ‐4 in these responses. Methods Human endometrial endothelial cells were treated with or without LPS ± LPS ‐ RS , a TLR ‐4 antagonist, via the binding of MD ‐2. After 24 hr, cell‐free supernatants were evaluated for cytokines by multiplex analysis and cell lysates were analyzed for tissue factor expression by Western blot. Results Treatment of HEEC s with LPS significantly upregulated the secretion of IL ‐6, IL ‐8, and G‐ CSF , and this was prevented by LPS ‐ RS . LPS also induced tissue factor expression by the HEEC s; however, this was unaffected by LPS ‐ RS . Conclusion These findings suggest that TLR ‐4 is functional in HEEC s and its activation by bacterial LPS induces a specific cytokine/chemokine response. However, bacterial LPS also induced tissue factor expression in what seemed to be a TLR ‐4‐independent fashion, suggesting that this bacterial component can act on the HEEC s through TLR ‐4‐dependent and TLR ‐4‐independent pathways. These findings indicate that endometrial endothelial cells may play an active role in uterine innate immunity." @default.
• W2120502238 created "2016-06-24" @default.
• W2120502238 creator A5004286262 @default.
• W2120502238 creator A5005367112 @default.
• W2120502238 creator A5005680652 @default.
• W2120502238 creator A5011581818 @default.
• W2120502238 creator A5020083084 @default.
• W2120502238 creator A5076026536 @default.
• W2120502238 creator A5080015616 @default.
• W2120502238 date "2012-06-04" @default.
• W2120502238 modified "2023-10-12" @default.
• W2120502238 title "Lipopolysaccharide Appears to Activate Human Endometrial Endothelial Cells Through <scp>TLR</scp>‐4‐Dependent and <scp>TLR</scp>‐4‐Independent Mechanisms" @default.
• W2120502238 cites W1503713311 @default.
• W2120502238 cites W1521045812 @default.
• W2120502238 cites W1984571968 @default.
• W2120502238 cites W1989350065 @default.
• W2120502238 cites W2004465286 @default.
• W2120502238 cites W2012963127 @default.
• W2120502238 cites W2017973506 @default.
• W2120502238 cites W2024179737 @default.
• W2120502238 cites W2028740565 @default.
• W2120502238 cites W2032002836 @default.
• W2120502238 cites W2039324855 @default.
• W2120502238 cites W2051068640 @default.
• W2120502238 cites W2052792411 @default.
• W2120502238 cites W2055693225 @default.
• W2120502238 cites W2056082879 @default.
• W2120502238 cites W2058956065 @default.
• W2120502238 cites W2059213579 @default.
• W2120502238 cites W2112472686 @default.
• W2120502238 cites W2113646062 @default.
• W2120502238 cites W2133449490 @default.
• W2120502238 cites W2149501430 @default.
• W2120502238 cites W2164922254 @default.
• W2120502238 cites W2170297455 @default.
• W2120502238 cites W4239267931 @default.
• W2120502238 doi "https://doi.org/10.1111/j.1600-0897.2012.01164.x" @default.
• W2120502238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3418410" @default.
• W2120502238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22672000" @default.
• W2120502238 hasPublicationYear "2012" @default.
• W2120502238 type Work @default.
• W2120502238 sameAs 2120502238 @default.
• W2120502238 citedByCount "29" @default.
• W2120502238 countsByYear W21205022382013 @default.
• W2120502238 countsByYear W21205022382014 @default.
• W2120502238 countsByYear W21205022382015 @default.
• W2120502238 countsByYear W21205022382016 @default.
• W2120502238 countsByYear W21205022382017 @default.
• W2120502238 countsByYear W21205022382018 @default.
• W2120502238 countsByYear W21205022382019 @default.
• W2120502238 countsByYear W21205022382020 @default.
• W2120502238 countsByYear W21205022382021 @default.
• W2120502238 countsByYear W21205022382023 @default.
• W2120502238 crossrefType "journal-article" @default.
• W2120502238 hasAuthorship W2120502238A5004286262 @default.
• W2120502238 hasAuthorship W2120502238A5005367112 @default.
• W2120502238 hasAuthorship W2120502238A5005680652 @default.
• W2120502238 hasAuthorship W2120502238A5011581818 @default.
• W2120502238 hasAuthorship W2120502238A5020083084 @default.
• W2120502238 hasAuthorship W2120502238A5076026536 @default.
• W2120502238 hasAuthorship W2120502238A5080015616 @default.
• W2120502238 hasBestOaLocation W21205022382 @default.
• W2120502238 hasConcept C123012128 @default.
• W2120502238 hasConcept C13373296 @default.
• W2120502238 hasConcept C134018914 @default.
• W2120502238 hasConcept C136449434 @default.
• W2120502238 hasConcept C17991360 @default.
• W2120502238 hasConcept C202751555 @default.
• W2120502238 hasConcept C203014093 @default.
• W2120502238 hasConcept C2776914184 @default.
• W2120502238 hasConcept C2778690821 @default.
• W2120502238 hasConcept C2778754761 @default.
• W2120502238 hasConcept C49039625 @default.
• W2120502238 hasConcept C55493867 @default.
• W2120502238 hasConcept C86803240 @default.
• W2120502238 hasConcept C8891405 @default.
• W2120502238 hasConcept C95444343 @default.
• W2120502238 hasConceptScore W2120502238C123012128 @default.
• W2120502238 hasConceptScore W2120502238C13373296 @default.
• W2120502238 hasConceptScore W2120502238C134018914 @default.
• W2120502238 hasConceptScore W2120502238C136449434 @default.
• W2120502238 hasConceptScore W2120502238C17991360 @default.
• W2120502238 hasConceptScore W2120502238C202751555 @default.
• W2120502238 hasConceptScore W2120502238C203014093 @default.
• W2120502238 hasConceptScore W2120502238C2776914184 @default.
• W2120502238 hasConceptScore W2120502238C2778690821 @default.
• W2120502238 hasConceptScore W2120502238C2778754761 @default.
• W2120502238 hasConceptScore W2120502238C49039625 @default.
• W2120502238 hasConceptScore W2120502238C55493867 @default.
• W2120502238 hasConceptScore W2120502238C86803240 @default.
• W2120502238 hasConceptScore W2120502238C8891405 @default.
• W2120502238 hasConceptScore W2120502238C95444343 @default.
• W2120502238 hasIssue "3" @default.
• W2120502238 hasLocation W21205022381 @default.
• W2120502238 hasLocation W21205022382 @default.
• W2120502238 hasLocation W21205022383 @default.
• W2120502238 hasLocation W21205022384 @default.
• W2120502238 hasOpenAccess W2120502238 @default.

• next