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- W2120504920 endingPage "970" @default.
- W2120504920 startingPage "959" @default.
- W2120504920 abstract "Anti–T cell globulin (ATG) is polyclonal IgG from rabbits immunized with human thymocytes or a human T cell line. Prophylaxis using ATG infused with conditioning for adult marrow or blood stem cell transplantation reduces both acute and chronic graft-versus-host disease (GVHD). However, ATG is not or minimally efficacious in steroid refractory GVHD treatment. Regarding preemptive therapy, ATG is promising; however, further work is needed on establishing adequate biomarkers to be used as triggers for preemptive therapy before it can be used routinely. Relapse is not increased by ATG, except possibly in the setting of reduced-intensity conditioning. Infections are probably increased when using high but not low-dose ATG, except for Epstein-Barr virus–driven post-transplantation lymphoproliferative disorder, which may be increased even with low-dose ATG. Survival is not improved with ATG; however, survival free of immunosuppressive therapy is improved. Pharmacokinetics of ATG are highly variable, resulting in highly variable areas under the time-concentration curves. Optimized dosing of ATG might improve transplantation outcomes. In conclusion, ATG reduces GVHD and, thus, may improve quality of life, without compromising survival." @default.
- W2120504920 created "2016-06-24" @default.
- W2120504920 creator A5020996390 @default.
- W2120504920 creator A5044045515 @default.
- W2120504920 creator A5084879148 @default.
- W2120504920 date "2015-06-01" @default.
- W2120504920 modified "2023-10-02" @default.
- W2120504920 title "Rabbit Anti–T Cell Globulin in Allogeneic Hematopoietic Cell Transplantation" @default.
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