FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120526297> ?p ?o ?g. }

• W2120526297 endingPage "213" @default.
• W2120526297 startingPage "201" @default.
• W2120526297 abstract "Human papillomavirus (HPV) type 16 infects the genital tract and is generally acknowledged to be a causative agent of cervical cancer. HPV infection alone is not sufficient to induce cervical cancer and other factors such as steroid hormones are thought to play a role in the establishment and/or progression of this disease. The HPV-16 E2 protein is required for virus replication and modulates viral gene expression whereas the HPV-16 E7 protein is required for cell transformation. We and others have shown that both the E2 and E7 proteins can induce apoptotic cell death in HPV-transformed and non-HPV transformed cell lines. Here we show that the steroid hormones oestrogen and progesterone can both increase the levels of E2- and E7-induced apoptosis. The oestrogen metabolite 16α-hydroxyoestrone also increases E2- and E7-induced cell death and the dietary component indole-3-carbinol, which reduces the formation of 16α-hydroxyoestrone from oestrogen, blocks the effects of oestrogen. Thus the metabolism of oestrogen to 16α-hydroxyoestrone appears to be required for the effects of this hormone on E2- and E7-induced cell death. We also show that the oestrogen receptor antagonist 3-hydroxytamoxifen blocks the effects of oestrogen on E2- and E7-induced cell death, whereas the anti-progesterone RU486 blocks the effects of both progesterone and oestrogen. We discuss these results in terms of the origin and progression of cervical cancer." @default.
• W2120526297 created "2016-06-24" @default.
• W2120526297 creator A5052026249 @default.
• W2120526297 creator A5076463502 @default.
• W2120526297 creator A5090535914 @default.
• W2120526297 date "2001-01-01" @default.
• W2120526297 modified "2023-10-17" @default.
• W2120526297 title "Oestrogen and progesterone increase the levels of apoptosis induced by the human papillomavirus type 16 E2 and E7 proteins" @default.
• W2120526297 cites W1541036303 @default.
• W2120526297 cites W174785446 @default.
• W2120526297 cites W1767781328 @default.
• W2120526297 cites W1964974888 @default.
• W2120526297 cites W1965080968 @default.
• W2120526297 cites W1966886063 @default.
• W2120526297 cites W1979805598 @default.
• W2120526297 cites W1979845383 @default.
• W2120526297 cites W1981126660 @default.
• W2120526297 cites W198328352 @default.
• W2120526297 cites W1983971803 @default.
• W2120526297 cites W1987350137 @default.
• W2120526297 cites W1989913063 @default.
• W2120526297 cites W2023228900 @default.
• W2120526297 cites W2024575518 @default.
• W2120526297 cites W2025990402 @default.
• W2120526297 cites W2028325343 @default.
• W2120526297 cites W2031841054 @default.
• W2120526297 cites W2038500217 @default.
• W2120526297 cites W2039382131 @default.
• W2120526297 cites W2040017782 @default.
• W2120526297 cites W2060786724 @default.
• W2120526297 cites W2061361679 @default.
• W2120526297 cites W2063758274 @default.
• W2120526297 cites W2064873755 @default.
• W2120526297 cites W2071938830 @default.
• W2120526297 cites W2075440912 @default.
• W2120526297 cites W2078148466 @default.
• W2120526297 cites W2086480947 @default.
• W2120526297 cites W2098470595 @default.
• W2120526297 cites W2106038494 @default.
• W2120526297 cites W2107162327 @default.
• W2120526297 cites W2114918609 @default.
• W2120526297 cites W2118110504 @default.
• W2120526297 cites W2119801679 @default.
• W2120526297 cites W2136111158 @default.
• W2120526297 cites W2143324471 @default.
• W2120526297 cites W2144511382 @default.
• W2120526297 cites W2151066134 @default.
• W2120526297 cites W2152160266 @default.
• W2120526297 cites W2166658061 @default.
• W2120526297 cites W2167223040 @default.
• W2120526297 cites W2168762926 @default.
• W2120526297 cites W2326847749 @default.
• W2120526297 cites W2334731906 @default.
• W2120526297 doi "https://doi.org/10.1099/0022-1317-82-1-201" @default.
• W2120526297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11125173" @default.
• W2120526297 hasPublicationYear "2001" @default.
• W2120526297 type Work @default.
• W2120526297 sameAs 2120526297 @default.
• W2120526297 citedByCount "43" @default.
• W2120526297 countsByYear W21205262972012 @default.
• W2120526297 countsByYear W21205262972013 @default.
• W2120526297 countsByYear W21205262972014 @default.
• W2120526297 countsByYear W21205262972015 @default.
• W2120526297 countsByYear W21205262972017 @default.
• W2120526297 countsByYear W21205262972018 @default.
• W2120526297 countsByYear W21205262972021 @default.
• W2120526297 countsByYear W21205262972022 @default.
• W2120526297 crossrefType "journal-article" @default.
• W2120526297 hasAuthorship W2120526297A5052026249 @default.
• W2120526297 hasAuthorship W2120526297A5076463502 @default.
• W2120526297 hasAuthorship W2120526297A5090535914 @default.
• W2120526297 hasBestOaLocation W21205262971 @default.
• W2120526297 hasConcept C121608353 @default.
• W2120526297 hasConcept C126322002 @default.
• W2120526297 hasConcept C134018914 @default.
• W2120526297 hasConcept C1491633281 @default.
• W2120526297 hasConcept C189014844 @default.
• W2120526297 hasConcept C190283241 @default.
• W2120526297 hasConcept C2777366897 @default.
• W2120526297 hasConcept C2777477808 @default.
• W2120526297 hasConcept C2778220009 @default.
• W2120526297 hasConcept C2778826759 @default.
• W2120526297 hasConcept C2779234561 @default.
• W2120526297 hasConcept C31573885 @default.
• W2120526297 hasConcept C502942594 @default.
• W2120526297 hasConcept C530470458 @default.
• W2120526297 hasConcept C54355233 @default.
• W2120526297 hasConcept C71315377 @default.
• W2120526297 hasConcept C71924100 @default.
• W2120526297 hasConcept C84606932 @default.
• W2120526297 hasConcept C86803240 @default.
• W2120526297 hasConcept C98717036 @default.
• W2120526297 hasConceptScore W2120526297C121608353 @default.
• W2120526297 hasConceptScore W2120526297C126322002 @default.
• W2120526297 hasConceptScore W2120526297C134018914 @default.
• W2120526297 hasConceptScore W2120526297C1491633281 @default.
• W2120526297 hasConceptScore W2120526297C189014844 @default.
• W2120526297 hasConceptScore W2120526297C190283241 @default.

• next