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- W2120563485 abstract "The epithelial adherens junction is an E-cadherin-based complex that controls tissue integrity and is stabilized at the plasma membrane by p120-catenin (p120, also known as CTNND1). Mutational and epigenetic inactivation of E-cadherin has been strongly implicated in the development and progression of cancer. In this setting, p120 translocates to the cytosol where it exerts oncogenic properties through aberrant regulation of Rho GTPases, growth factor receptor signaling and derepression of Kaiso (also known as ZBTB33) target genes. In contrast, indirect inactivation of the adherens junction through conditional knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can also function as a tumor suppressor. Supporting these opposing functions are findings in human cancer, which show that either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma. Underlying this dual biological phenomenon might be the context-dependent regulation of Rho GTPases in the cytosol and the derepression of Kaiso target genes. Here, we discuss past and present findings that implicate p120 in the regulation of cancer progression and highlight opportunities for clinical intervention." @default.
- W2120563485 created "2016-06-24" @default.
- W2120563485 creator A5005400331 @default.
- W2120563485 creator A5050463017 @default.
- W2120563485 creator A5051227603 @default.
- W2120563485 creator A5068089191 @default.
- W2120563485 date "2013-08-15" @default.
- W2120563485 modified "2023-10-17" @default.
- W2120563485 title "p120-catenin in cancer – mechanisms, models and opportunities for intervention" @default.
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