FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120589083> ?p ?o ?g. }

• W2120589083 abstract "Abstract Background HIV-1 entry into target lymphocytes requires the activity of actin adaptors that stabilize and reorganize cortical F-actin, like moesin and filamin-A. These alterations are necessary for the redistribution of CD4-CXCR4/CCR5 to one pole of the cell, a process that increases the probability of HIV-1 Envelope (Env)-CD4/co-receptor interactions and that generates the tension at the plasma membrane necessary to potentiate fusion pore formation, thereby favouring early HIV-1 infection. However, it remains unclear whether the dynamic processing of F-actin and the amount of cortical actin available during the initial virus-cell contact are required to such events. Results Here we show that gelsolin restructures cortical F-actin during HIV-1 Env-gp120-mediated signalling, without affecting cell-surface expression of receptors or viral co-receptor signalling. Remarkably, efficient HIV-1 Env-mediated membrane fusion and infection of permissive lymphocytes were impaired when gelsolin was either overexpressed or silenced, which led to a loss or gain of cortical actin, respectively. Indeed, HIV-1 Env-gp120-induced F-actin reorganization and viral receptor capping were impaired under these experimental conditions. Moreover, gelsolin knockdown promoted HIV-1 Env-gp120-mediated aberrant pseudopodia formation. These perturbed-actin events are responsible for the inhibition of early HIV-1 infection. Conclusions For the first time we provide evidence that through its severing of cortical actin, and by controlling the amount of actin available for reorganization during HIV-1 Env-mediated viral fusion, entry and infection, gelsolin can constitute a barrier that restricts HIV-1 infection of CD4+ lymphocytes in a pre-fusion step. These findings provide important insights into the complex molecular and actin-associated dynamics events that underlie early viral infection. Thus, we propose that gelsolin is a new factor that can limit HIV-1 infection acting at a pre-fusion step, and accordingly, cell-signals that regulate gelsolin expression and/or its actin-severing activity may be crucial to combat HIV-1 infection." @default.
• W2120589083 created "2016-06-24" @default.
• W2120589083 creator A5012674591 @default.
• W2120589083 creator A5016693084 @default.
• W2120589083 creator A5038782747 @default.
• W2120589083 creator A5066171893 @default.
• W2120589083 creator A5072998703 @default.
• W2120589083 creator A5073445313 @default.
• W2120589083 creator A5080325052 @default.
• W2120589083 creator A5088003575 @default.
• W2120589083 date "2013-04-10" @default.
• W2120589083 modified "2023-10-07" @default.
• W2120589083 title "Gelsolin activity controls efficient early HIV-1 infection" @default.
• W2120589083 cites W105877377 @default.
• W2120589083 cites W1502324353 @default.
• W2120589083 cites W1551883442 @default.
• W2120589083 cites W1968193348 @default.
• W2120589083 cites W1969877587 @default.
• W2120589083 cites W1982865936 @default.
• W2120589083 cites W1994678168 @default.
• W2120589083 cites W1996321192 @default.
• W2120589083 cites W2005428335 @default.
• W2120589083 cites W2006074082 @default.
• W2120589083 cites W2009671832 @default.
• W2120589083 cites W2010190244 @default.
• W2120589083 cites W2013346825 @default.
• W2120589083 cites W2015039243 @default.
• W2120589083 cites W2015320456 @default.
• W2120589083 cites W2015920669 @default.
• W2120589083 cites W2032984048 @default.
• W2120589083 cites W2036178039 @default.
• W2120589083 cites W2041982728 @default.
• W2120589083 cites W2045626973 @default.
• W2120589083 cites W2049401141 @default.
• W2120589083 cites W2062456632 @default.
• W2120589083 cites W2067693929 @default.
• W2120589083 cites W2069672675 @default.
• W2120589083 cites W2074073397 @default.
• W2120589083 cites W2077462876 @default.
• W2120589083 cites W2080702547 @default.
• W2120589083 cites W2081462289 @default.
• W2120589083 cites W2082742400 @default.
• W2120589083 cites W2083845998 @default.
• W2120589083 cites W2089695334 @default.
• W2120589083 cites W2090712867 @default.
• W2120589083 cites W2097670317 @default.
• W2120589083 cites W2105384628 @default.
• W2120589083 cites W2105608776 @default.
• W2120589083 cites W2108062080 @default.
• W2120589083 cites W2123036936 @default.
• W2120589083 cites W2128034242 @default.
• W2120589083 cites W2129303477 @default.
• W2120589083 cites W2132008468 @default.
• W2120589083 cites W2136818856 @default.
• W2120589083 cites W2139695852 @default.
• W2120589083 cites W2143614051 @default.
• W2120589083 cites W2145367033 @default.
• W2120589083 cites W2156700030 @default.
• W2120589083 cites W2159266772 @default.
• W2120589083 cites W2284989847 @default.
• W2120589083 cites W4211140976 @default.
• W2120589083 doi "https://doi.org/10.1186/1742-4690-10-39" @default.
• W2120589083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3626799" @default.
• W2120589083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23575248" @default.
• W2120589083 hasPublicationYear "2013" @default.
• W2120589083 type Work @default.
• W2120589083 sameAs 2120589083 @default.
• W2120589083 citedByCount "37" @default.
• W2120589083 countsByYear W21205890832013 @default.
• W2120589083 countsByYear W21205890832014 @default.
• W2120589083 countsByYear W21205890832015 @default.
• W2120589083 countsByYear W21205890832016 @default.
• W2120589083 countsByYear W21205890832017 @default.
• W2120589083 countsByYear W21205890832018 @default.
• W2120589083 countsByYear W21205890832019 @default.
• W2120589083 countsByYear W21205890832020 @default.
• W2120589083 countsByYear W21205890832021 @default.
• W2120589083 countsByYear W21205890832022 @default.
• W2120589083 countsByYear W21205890832023 @default.
• W2120589083 crossrefType "journal-article" @default.
• W2120589083 hasAuthorship W2120589083A5012674591 @default.
• W2120589083 hasAuthorship W2120589083A5016693084 @default.
• W2120589083 hasAuthorship W2120589083A5038782747 @default.
• W2120589083 hasAuthorship W2120589083A5066171893 @default.
• W2120589083 hasAuthorship W2120589083A5072998703 @default.
• W2120589083 hasAuthorship W2120589083A5073445313 @default.
• W2120589083 hasAuthorship W2120589083A5080325052 @default.
• W2120589083 hasAuthorship W2120589083A5088003575 @default.
• W2120589083 hasBestOaLocation W21205890831 @default.
• W2120589083 hasConcept C103038307 @default.
• W2120589083 hasConcept C125705527 @default.
• W2120589083 hasConcept C140704245 @default.
• W2120589083 hasConcept C142669718 @default.
• W2120589083 hasConcept C1491633281 @default.
• W2120589083 hasConcept C159047783 @default.
• W2120589083 hasConcept C159654299 @default.
• W2120589083 hasConcept C170493617 @default.
• W2120589083 hasConcept C195616568 @default.
• W2120589083 hasConcept C199528912 @default.
• W2120589083 hasConcept C203014093 @default.

• next