FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120595908> ?p ?o ?g. }

• W2120595908 endingPage "10895" @default.
• W2120595908 startingPage "10890" @default.
• W2120595908 abstract "Understanding molecular kinetics, and particularly protein folding, is a classic grand challenge in molecular biophysics. Network models, such as Markov state models (MSMs), are one potential solution to this problem. MSMs have recently yielded quantitative agreement with experimentally derived structures and folding rates for specific systems, leaving them positioned to potentially provide a deeper understanding of molecular kinetics that can lead to experimentally testable hypotheses. Here we use existing MSMs for the villin headpiece and NTL9, which were constructed from atomistic simulations, to accomplish this goal. In addition, we provide simpler, humanly comprehensible networks that capture the essence of molecular kinetics and reproduce qualitative phenomena like the apparent two-state folding often seen in experiments. Together, these models show that protein dynamics are dominated by stochastic jumps between numerous metastable states and that proteins have heterogeneous unfolded states (many unfolded basins that interconvert more rapidly with the native state than with one another) yet often still appear two-state. Most importantly, we find that protein native states are hubs that can be reached quickly from any other state. However, metastability and a web of nonnative states slow the average folding rate. Experimental tests for these findings and their implications for other fields, like protein design, are also discussed." @default.
• W2120595908 created "2016-06-24" @default.
• W2120595908 creator A5029297375 @default.
• W2120595908 creator A5032418986 @default.
• W2120595908 date "2010-06-01" @default.
• W2120595908 modified "2023-10-17" @default.
• W2120595908 title "Protein folded states are kinetic hubs" @default.
• W2120595908 cites W1600015000 @default.
• W2120595908 cites W1963601673 @default.
• W2120595908 cites W1965159797 @default.
• W2120595908 cites W1969554454 @default.
• W2120595908 cites W1969903391 @default.
• W2120595908 cites W1975688079 @default.
• W2120595908 cites W1976831186 @default.
• W2120595908 cites W1979038840 @default.
• W2120595908 cites W1979070806 @default.
• W2120595908 cites W1986155795 @default.
• W2120595908 cites W1988131005 @default.
• W2120595908 cites W1990593157 @default.
• W2120595908 cites W2001509033 @default.
• W2120595908 cites W2005726448 @default.
• W2120595908 cites W2008620264 @default.
• W2120595908 cites W2013081775 @default.
• W2120595908 cites W2014095962 @default.
• W2120595908 cites W2016336300 @default.
• W2120595908 cites W2018657646 @default.
• W2120595908 cites W2020563037 @default.
• W2120595908 cites W2021541427 @default.
• W2120595908 cites W2023832497 @default.
• W2120595908 cites W2025899185 @default.
• W2120595908 cites W2031243389 @default.
• W2120595908 cites W2033303774 @default.
• W2120595908 cites W2036755526 @default.
• W2120595908 cites W2037244907 @default.
• W2120595908 cites W2039592270 @default.
• W2120595908 cites W2043224212 @default.
• W2120595908 cites W2046285452 @default.
• W2120595908 cites W2047935897 @default.
• W2120595908 cites W2050817368 @default.
• W2120595908 cites W2053348581 @default.
• W2120595908 cites W2055118532 @default.
• W2120595908 cites W2061844749 @default.
• W2120595908 cites W2066795144 @default.
• W2120595908 cites W2067714785 @default.
• W2120595908 cites W2073084983 @default.
• W2120595908 cites W2081926098 @default.
• W2120595908 cites W2084642783 @default.
• W2120595908 cites W2087517964 @default.
• W2120595908 cites W2091683533 @default.
• W2120595908 cites W2091707670 @default.
• W2120595908 cites W2098093830 @default.
• W2120595908 cites W2112090702 @default.
• W2120595908 cites W2116110141 @default.
• W2120595908 cites W2117000100 @default.
• W2120595908 cites W2119588077 @default.
• W2120595908 cites W2129020329 @default.
• W2120595908 cites W2131395827 @default.
• W2120595908 cites W2139327615 @default.
• W2120595908 cites W2140565568 @default.
• W2120595908 cites W2161384956 @default.
• W2120595908 cites W2171755502 @default.
• W2120595908 cites W2242536402 @default.
• W2120595908 doi "https://doi.org/10.1073/pnas.1003962107" @default.
• W2120595908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890711" @default.
• W2120595908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20534497" @default.
• W2120595908 hasPublicationYear "2010" @default.
• W2120595908 type Work @default.
• W2120595908 sameAs 2120595908 @default.
• W2120595908 citedByCount "207" @default.
• W2120595908 countsByYear W21205959082012 @default.
• W2120595908 countsByYear W21205959082013 @default.
• W2120595908 countsByYear W21205959082014 @default.
• W2120595908 countsByYear W21205959082015 @default.
• W2120595908 countsByYear W21205959082016 @default.
• W2120595908 countsByYear W21205959082017 @default.
• W2120595908 countsByYear W21205959082018 @default.
• W2120595908 countsByYear W21205959082019 @default.
• W2120595908 countsByYear W21205959082020 @default.
• W2120595908 countsByYear W21205959082021 @default.
• W2120595908 countsByYear W21205959082022 @default.
• W2120595908 countsByYear W21205959082023 @default.
• W2120595908 crossrefType "journal-article" @default.
• W2120595908 hasAuthorship W2120595908A5029297375 @default.
• W2120595908 hasAuthorship W2120595908A5032418986 @default.
• W2120595908 hasBestOaLocation W21205959081 @default.
• W2120595908 hasConcept C119599485 @default.
• W2120595908 hasConcept C119857082 @default.
• W2120595908 hasConcept C121332964 @default.
• W2120595908 hasConcept C121864883 @default.
• W2120595908 hasConcept C12554922 @default.
• W2120595908 hasConcept C127413603 @default.
• W2120595908 hasConcept C147597530 @default.
• W2120595908 hasConcept C148898269 @default.
• W2120595908 hasConcept C178790620 @default.
• W2120595908 hasConcept C185592680 @default.
• W2120595908 hasConcept C19472624 @default.
• W2120595908 hasConcept C204328495 @default.
• W2120595908 hasConcept C2776545253 @default.

• next