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- W2120603720 abstract "Glutamate evoked pertussis toxin-sensitive currents in Xenopus oocytes expressing metabotropic glutamate receptor subtype 1 (mGluR1) and exogenous Gi1 alpha. The mGluR1-currents were completely blocked by U-73122, a phospholipase C (PLC) inhibitor and by niflumic acid, a chloride channel blocker. In the oocyte further coinjected with poly(A)+ RNA from the guinea pig cerebellum, the mGluR1-currents were inhibited by U-50488H, an opioid kappa-agonist, and this inhibition was blocked by norbinaltorphimine, an opioid kappa-antagonist. These findings suggest that the mRNA encoding a novel subtype of opioid kappa-receptor which inhibits Gi1-PLC-mediated currents is present in guinea pig cerebellar poly(A)+ fractions." @default.
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- W2120603720 date "1995-11-20" @default.
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- W2120603720 title "Evidence for a metabostatic opioid ϰ-receptor inhibiting pertussis toxin-sensitive metabotropic glutamate receptor-currents in<i>Xenopus</i>oocytes" @default.
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- W2120603720 doi "https://doi.org/10.1016/0014-5793(95)01204-r" @default.
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