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• W2120672234 abstract "Recently, the ventilatory variation in pre-ejection period (ΔPEP) was found to be useful in the prediction of fluid-responsiveness of patients in shock. In the present study we investigated the behavior of the ventilation-induced variations in the systolic timing intervals in response to a graded hemorrhage protocol. The timing intervals studied included the ventilatory variation in ventricular electromechanical delay (ΔEMD), isovolumic contraction period (determined from the arterial pressure waveform, ΔAIC), pulse travel time (ΔPTT), and ΔPEP. ΔAIC and ΔPEP were evaluated in the aorta and carotid artery (annotated by subscripts Ao and CA) and were compared with the responses of pulse pressure variation (ΔPP Ao ) and stroke volume variation (ΔSV). The graded hemorrhage protocol, followed by resuscitation using norepinephrine and autologous blood transfusion, was performed in eight anesthetized Yorkshire X Landrace swine. ΔAIC Ao , ΔAIC CA , ΔPEP Ao , ΔPEP CA , ΔPP Ao , ΔPP CA , and ΔSV showed significant increases during the graded hemorrhage and significant decreases during the subsequent resuscitation. ΔAIC Ao , ΔAIC CA , ΔPEP Ao , and ΔPEP CA all correlated well with ΔPP Ao and ΔSV (all r ≥ 0.8, all P < 0.001). ΔEMD and ΔPTT did not significantly change throughout the protocol. In contrast with ΔPEP Ao , which was significantly higher than ΔPEP CA ( P < 0.01), ΔAIC Ao was not different from ΔAIC CA . In conclusion, ventilation-induced preload variation principally affects the arterially determined isovolumic contraction period (AIC). Moreover, ΔAIC can be determined solely from the arterial pressure waveform, whereas ΔPEP also requires ECG measurement. Importantly, ΔAIC determined from either the carotid or aortic pressure waveform are interchangeable, suggesting that, in contrast with ΔPEP, ΔAIC may be site independent." @default.
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• W2120672234 date "2013-12-15" @default.
• W2120672234 modified "2023-09-25" @default.
• W2120672234 title "A novel approach to assess hemorrhagic shock severity using the arterially determined left ventricular isovolumic contraction period" @default.
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• W2120672234 doi "https://doi.org/10.1152/ajpheart.00504.2013" @default.
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