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• W2120673604 abstract "Abstract There is significant clinical interest in the factors that influence the development of tamoxifen resistance in estrogen receptor-α (ER-α)–positive breast cancers. Recent studies suggest that in ER-positive breast tumor cells, elevated protein levels, and in particular, nuclear localization of p21-activated kinase 1 (PAK1), is associated with the progressive limitation of tamoxifen sensitivity. These phenotypic effects of PAK1 in model systems are mechanistically linked with the ability of PAK1 to phosphorylate ER-α on serine 305 and subsequent secondary activation of serine 118. These findings prompt further investigation of how nuclear signaling by PAK1 may affect estrogen's action and whether tamoxifen resistance might be prevented or reversed by PAK1 inhibition. (Cancer Res 2006; 66(12): 5985-8)" @default.
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• W2120673604 date "2006-06-15" @default.
• W2120673604 modified "2023-10-18" @default.
• W2120673604 title "Nuclear p21-Activated Kinase 1 in Breast Cancer Packs Off Tamoxifen Sensitivity" @default.
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• W2120673604 doi "https://doi.org/10.1158/0008-5472.can-06-0978" @default.
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