FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120679080> ?p ?o ?g. }

• W2120679080 endingPage "544" @default.
• W2120679080 startingPage "542" @default.
• W2120679080 abstract "The formation of brain edema, commonly occurring as a potentially lethal complication of acute hyponatremia, is delayed following knockout of the water channel aquaporin-4 (AQP4). Here we show by high-resolution immunogold analysis of the blood-brain-barrier that AQP4 is expressed in brain endothelial cells as well as in the perivascular membranes of astrocyte endfeet. A selective removal of perivascular AQP4 by alpha-syntrophin deletion delays the buildup of brain edema (assessed by Diffusion-weighted MRI) following water intoxication, despite the presence of a normal complement of endothelial AQP4. This indicates that the perivascular membrane domain, which is peripheral to the endothelial blood-brain barrier, may control the rate of osmotically driven water entry. This study is also the first to demonstrate that the time course of edema development differs among brain regions, probably reflecting differences in aquaporin-4 distribution. The resolution of the molecular basis and subcellular site of osmotically driven brain water uptake should help design new therapies for acute brain edema." @default.
• W2120679080 created "2016-06-24" @default.
• W2120679080 creator A5017989879 @default.
• W2120679080 creator A5020293386 @default.
• W2120679080 creator A5026325424 @default.
• W2120679080 creator A5059342248 @default.
• W2120679080 creator A5066387778 @default.
• W2120679080 creator A5074921206 @default.
• W2120679080 creator A5082010522 @default.
• W2120679080 creator A5083596914 @default.
• W2120679080 creator A5087096006 @default.
• W2120679080 creator A5089884601 @default.
• W2120679080 date "2004-01-20" @default.
• W2120679080 modified "2023-10-16" @default.
• W2120679080 title "Alpha syntrophin deletion removes the perivascular but not the endothelial pool of aquaporin‐4 at the blood‐brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia" @default.
• W2120679080 cites W1495656315 @default.
• W2120679080 cites W1535419310 @default.
• W2120679080 cites W1539041562 @default.
• W2120679080 cites W1597908762 @default.
• W2120679080 cites W1894872962 @default.
• W2120679080 cites W1967001670 @default.
• W2120679080 cites W1975528228 @default.
• W2120679080 cites W1980829307 @default.
• W2120679080 cites W1986088843 @default.
• W2120679080 cites W1995419987 @default.
• W2120679080 cites W2012734719 @default.
• W2120679080 cites W2031895509 @default.
• W2120679080 cites W2044468890 @default.
• W2120679080 cites W2055810294 @default.
• W2120679080 cites W2059943099 @default.
• W2120679080 cites W2063970689 @default.
• W2120679080 cites W2071403683 @default.
• W2120679080 cites W2087561238 @default.
• W2120679080 cites W2099790143 @default.
• W2120679080 cites W2113404770 @default.
• W2120679080 cites W2117021588 @default.
• W2120679080 cites W2124292468 @default.
• W2120679080 cites W2127842729 @default.
• W2120679080 cites W2135157479 @default.
• W2120679080 cites W2150702820 @default.
• W2120679080 cites W2234942960 @default.
• W2120679080 doi "https://doi.org/10.1096/fj.03-0869fje" @default.
• W2120679080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14734638" @default.
• W2120679080 hasPublicationYear "2004" @default.
• W2120679080 type Work @default.
• W2120679080 sameAs 2120679080 @default.
• W2120679080 citedByCount "222" @default.
• W2120679080 countsByYear W21206790802012 @default.
• W2120679080 countsByYear W21206790802013 @default.
• W2120679080 countsByYear W21206790802014 @default.
• W2120679080 countsByYear W21206790802015 @default.
• W2120679080 countsByYear W21206790802016 @default.
• W2120679080 countsByYear W21206790802017 @default.
• W2120679080 countsByYear W21206790802018 @default.
• W2120679080 countsByYear W21206790802019 @default.
• W2120679080 countsByYear W21206790802020 @default.
• W2120679080 countsByYear W21206790802021 @default.
• W2120679080 countsByYear W21206790802022 @default.
• W2120679080 countsByYear W21206790802023 @default.
• W2120679080 crossrefType "journal-article" @default.
• W2120679080 hasAuthorship W2120679080A5017989879 @default.
• W2120679080 hasAuthorship W2120679080A5020293386 @default.
• W2120679080 hasAuthorship W2120679080A5026325424 @default.
• W2120679080 hasAuthorship W2120679080A5059342248 @default.
• W2120679080 hasAuthorship W2120679080A5066387778 @default.
• W2120679080 hasAuthorship W2120679080A5074921206 @default.
• W2120679080 hasAuthorship W2120679080A5082010522 @default.
• W2120679080 hasAuthorship W2120679080A5083596914 @default.
• W2120679080 hasAuthorship W2120679080A5087096006 @default.
• W2120679080 hasAuthorship W2120679080A5089884601 @default.
• W2120679080 hasConcept C126322002 @default.
• W2120679080 hasConcept C142724271 @default.
• W2120679080 hasConcept C154280991 @default.
• W2120679080 hasConcept C15755913 @default.
• W2120679080 hasConcept C169760540 @default.
• W2120679080 hasConcept C185592680 @default.
• W2120679080 hasConcept C2777542381 @default.
• W2120679080 hasConcept C2778402981 @default.
• W2120679080 hasConcept C2780886150 @default.
• W2120679080 hasConcept C529278444 @default.
• W2120679080 hasConcept C71924100 @default.
• W2120679080 hasConcept C86803240 @default.
• W2120679080 hasConcept C95444343 @default.
• W2120679080 hasConceptScore W2120679080C126322002 @default.
• W2120679080 hasConceptScore W2120679080C142724271 @default.
• W2120679080 hasConceptScore W2120679080C154280991 @default.
• W2120679080 hasConceptScore W2120679080C15755913 @default.
• W2120679080 hasConceptScore W2120679080C169760540 @default.
• W2120679080 hasConceptScore W2120679080C185592680 @default.
• W2120679080 hasConceptScore W2120679080C2777542381 @default.
• W2120679080 hasConceptScore W2120679080C2778402981 @default.
• W2120679080 hasConceptScore W2120679080C2780886150 @default.
• W2120679080 hasConceptScore W2120679080C529278444 @default.
• W2120679080 hasConceptScore W2120679080C71924100 @default.
• W2120679080 hasConceptScore W2120679080C86803240 @default.
• W2120679080 hasConceptScore W2120679080C95444343 @default.
• W2120679080 hasFunder F4320320366 @default.
• W2120679080 hasFunder F4320323299 @default.

• next