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• W2120702690 abstract "Abstract Motivation: Experimental design, hypothesis-testing and model-building in the current data-rich environment require the biologists' to collect, evaluate and integrate large amounts of information of many disparate kinds. Developing a unified framework for the representation and conceptual integration of biological data and processes is a major challenge in bioinformatics because of the variety of available data and the different levels of detail at which biological processes can be considered. Results: We have developed the HyBrow (Hypothesis Browser) system as a prototype bioinformatics tool for designing hypotheses and evaluating them for consistency with existing knowledge. HyBrow consists of a modeling framework with the ability to accommodate diverse biological information sources, an event-based ontology for representing biological processes at different levels of detail, a database to query information in the ontology and programs to perform hypothesis design and evaluation. We demonstrate the HyBrow prototype using the galactose gene network in Saccharomyces cerevisiae as our test system, and evaluate alternative hypotheses for consistency with stored information. Availability: www.hybrow.org" @default.
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• W2120702690 date "2004-08-04" @default.
• W2120702690 modified "2023-09-23" @default.
• W2120702690 title "HyBrow: a prototype system for computer-aided hypothesis evaluation" @default.
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• W2120702690 doi "https://doi.org/10.1093/bioinformatics/bth905" @default.
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