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• W2120703089 abstract "Background:The outcome of 20 patients with newly diagnosed mantle-cell lymphoma (MCL) treated on a prospective trial of autologous stem-cell transplantation (ASCT) and rituximab immunotherapy was compared with the outcome of 40 matched historical control patients treated with standard combination chemotherapy.Patients and methods:Control patients with MCL were identified from a lymphoma database, and pairs were matched with patients receiving ASCT–rituximab for stage of disease, gender and age (±5 years). Only patients treated with an anthracycline- or cyclophosphamide–fludarabine-based regimen were included.Results:Seventeen of 20 patients who received ASCT–rituximab remain alive in remission at a median of 30 months from diagnosis; one patient relapsed 2 years post-ASCT, and two died at 7 and 11 months post-ASCT without evidence of lymphoma. Of 40 patients treated with conventional chemotherapy, with a median follow-up of 80 months, 33 have relapsed or progressed and 29 have died. Overall (OS) and progression-free (PFS) survival were superior in patients treated with ASCT–rituximab compared with those treated with conventional chemotherapy (PFS at 3 years, 89% versus 29%, P <0.00001; OS at 3 years, 88% versus 65%, P = 0.052).Conclusions:This matched-pair analysis suggests that patients with advanced-stage MCL treated with ASCT–rituximab had statistically significantly better PFS and a trend toward better OS than patients treated with conventional chemotherapy. Longer follow-up will determine response duration and the true impact of this treatment strategy on PFS and OS." @default.
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• W2120703089 date "2004-02-01" @default.
• W2120703089 modified "2023-09-27" @default.
• W2120703089 title "Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis" @default.
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• W2120703089 doi "https://doi.org/10.1093/annonc/mdh069" @default.
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