FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2120717657> ?p ?o ?g. }

• W2120717657 endingPage "e112047" @default.
• W2120717657 startingPage "e112047" @default.
• W2120717657 abstract "Respiratory syncytial virus (RSV) infection is the second most important cause of death in the first year of life, and early RSV infections are associated with the development of asthma. Breastfeeding and serum IgG have been shown to protect against RSV infection. Yet, many infants depend on bovine milk-based nutrition, which at present lacks intact immunoglobulins.To investigate whether IgG purified from bovine milk (bIgG) can modulate immune responses against human RSV.ELISAs were performed to analyse binding of bIgG to human respiratory pathogens. bIgG or hRSV was coated to plates to assess dose-dependent binding of bIgG to human Fcγ receptors (FcγR) or bIgG-mediated binding of myeloid cells to hRSV respectively. S. Epidermidis and RSV were used to test bIgG-mediated binding and internalisation of pathogens by myeloid cells. Finally, the ability of bIgG to neutralise infection of HEp2 cells by hRSV was evaluated.bIgG recognised human RSV, influenza haemagglutinin and Haemophilus influenza. bIgG bound to FcγRII on neutrophils, monocytes and macrophages, but not to FcγRI and FcγRIII, and could bind simultaneously to hRSV and human FcγRII on neutrophils. In addition, human neutrophils and dendritic cells internalised pathogens that were opsonised with bIgG. Finally, bIgG could prevent infection of HEp2 cells by hRSV.The data presented here show that bIgG binds to hRSV and other human respiratory pathogens and induces effector functions through binding to human FcγRII on phagocytes. Thus bovine IgG may contribute to immune protection against RSV." @default.
• W2120717657 created "2016-06-24" @default.
• W2120717657 creator A5011113549 @default.
• W2120717657 creator A5015545205 @default.
• W2120717657 creator A5024910051 @default.
• W2120717657 creator A5028306786 @default.
• W2120717657 creator A5030773770 @default.
• W2120717657 creator A5052814396 @default.
• W2120717657 creator A5076736189 @default.
• W2120717657 date "2014-11-06" @default.
• W2120717657 modified "2023-10-17" @default.
• W2120717657 title "Specificity and Effector Functions of Human RSV-Specific IgG from Bovine Milk" @default.
• W2120717657 cites W1484926268 @default.
• W2120717657 cites W1497741198 @default.
• W2120717657 cites W1530930152 @default.
• W2120717657 cites W1635353275 @default.
• W2120717657 cites W1872290146 @default.
• W2120717657 cites W1967881931 @default.
• W2120717657 cites W1982793548 @default.
• W2120717657 cites W1991653424 @default.
• W2120717657 cites W1992486795 @default.
• W2120717657 cites W1992958213 @default.
• W2120717657 cites W1994200209 @default.
• W2120717657 cites W2009979118 @default.
• W2120717657 cites W2030200460 @default.
• W2120717657 cites W2046142451 @default.
• W2120717657 cites W2048309337 @default.
• W2120717657 cites W2053516505 @default.
• W2120717657 cites W2054601965 @default.
• W2120717657 cites W2059624843 @default.
• W2120717657 cites W2062985080 @default.
• W2120717657 cites W2064779656 @default.
• W2120717657 cites W2066370188 @default.
• W2120717657 cites W2069075878 @default.
• W2120717657 cites W2069125860 @default.
• W2120717657 cites W2074111056 @default.
• W2120717657 cites W2077332396 @default.
• W2120717657 cites W2088254766 @default.
• W2120717657 cites W2090277647 @default.
• W2120717657 cites W2097008424 @default.
• W2120717657 cites W2098196189 @default.
• W2120717657 cites W2102341021 @default.
• W2120717657 cites W2103517048 @default.
• W2120717657 cites W2107897726 @default.
• W2120717657 cites W2120949068 @default.
• W2120717657 cites W2125065061 @default.
• W2120717657 cites W2127532535 @default.
• W2120717657 cites W2128862088 @default.
• W2120717657 cites W2129275039 @default.
• W2120717657 cites W2129851516 @default.
• W2120717657 cites W2151007400 @default.
• W2120717657 cites W2154395248 @default.
• W2120717657 cites W2161853794 @default.
• W2120717657 cites W2162334426 @default.
• W2120717657 cites W2163731669 @default.
• W2120717657 cites W2164690176 @default.
• W2120717657 cites W2169665123 @default.
• W2120717657 cites W2172141229 @default.
• W2120717657 cites W2254982040 @default.
• W2120717657 doi "https://doi.org/10.1371/journal.pone.0112047" @default.
• W2120717657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4222812" @default.
• W2120717657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25375837" @default.
• W2120717657 hasPublicationYear "2014" @default.
• W2120717657 type Work @default.
• W2120717657 sameAs 2120717657 @default.
• W2120717657 citedByCount "29" @default.
• W2120717657 countsByYear W21207176572015 @default.
• W2120717657 countsByYear W21207176572017 @default.
• W2120717657 countsByYear W21207176572018 @default.
• W2120717657 countsByYear W21207176572019 @default.
• W2120717657 countsByYear W21207176572020 @default.
• W2120717657 countsByYear W21207176572021 @default.
• W2120717657 countsByYear W21207176572022 @default.
• W2120717657 countsByYear W21207176572023 @default.
• W2120717657 crossrefType "journal-article" @default.
• W2120717657 hasAuthorship W2120717657A5011113549 @default.
• W2120717657 hasAuthorship W2120717657A5015545205 @default.
• W2120717657 hasAuthorship W2120717657A5024910051 @default.
• W2120717657 hasAuthorship W2120717657A5028306786 @default.
• W2120717657 hasAuthorship W2120717657A5030773770 @default.
• W2120717657 hasAuthorship W2120717657A5052814396 @default.
• W2120717657 hasAuthorship W2120717657A5076736189 @default.
• W2120717657 hasBestOaLocation W21207176571 @default.
• W2120717657 hasConcept C159047783 @default.
• W2120717657 hasConcept C159654299 @default.
• W2120717657 hasConcept C203014093 @default.
• W2120717657 hasConcept C2522874641 @default.
• W2120717657 hasConcept C2780727368 @default.
• W2120717657 hasConcept C2780813555 @default.
• W2120717657 hasConcept C2781445406 @default.
• W2120717657 hasConcept C40677261 @default.
• W2120717657 hasConcept C51785407 @default.
• W2120717657 hasConcept C542903549 @default.
• W2120717657 hasConcept C86803240 @default.
• W2120717657 hasConcept C8891405 @default.
• W2120717657 hasConcept C89423630 @default.
• W2120717657 hasConceptScore W2120717657C159047783 @default.
• W2120717657 hasConceptScore W2120717657C159654299 @default.

• next